RNA Molecular Biology Laboratory - Université Libre de Bruxelles - Ribosome biogenesis, RNA processing, RNA modification, nucleolus, cancer, ribosomopathy
Brussels, Belgium
Joined January 2013
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Denis LJ Lafontaine retweeted
Online Now: Hypoxia-induced ribosomal RNA modifications in the peptidyl-transferase center contribute to anaerobic growth of bacteria dlvr.it/TPlKxf
Denis LJ Lafontaine retweeted
Combining sequencing and imaging, @sofiquinodoz maps the spatiotemporal dynamics of rRNA processing, demonstrating how rRNA serves as both a scaffold and a substrate for the nucleolus—a multiphase, liquid-like structure. nature.com/articles/s41586-0… @brangwynnelab @omenndarlingbio
Denis LJ Lafontaine retweeted
Mice with cardiomyocyte-specific knockout of #YTHDF3 subjected to #cardiac stress had no increase in protein synthesis or cardiac hypertrophy. @Crabolli @AccorneroLab @OhioStatePCB @BrownMolBio bit.ly/4ekbfOH
Denis LJ Lafontaine retweeted
Our tour de force into the nucleolar world — a stunning exploration of spatial organization and the functional choreography of ribosome biogenesis now out in Nature✨ tinyurl.com/5n7jk3uz
Led by @sofiquinodoz, @jiang_lifei, @brangwynnelab, with theory partners @QiweiYu2, Andrej Kosmrlj, and all of our collaborators!!
Now on the Princeton Engineering and ODBI sites, a new mapping tool that allows researchers to peer deep into cells' inner compartments to watch and control ribosome assembly, shedding new light on the machinery responsible for making proteins.
ALT The words "New tool allows researchers to track assembly of cells' protein-making machines, image by Holly Cheng" with microscope image of pink and green globules
Denis LJ Lafontaine retweeted
Now on the Princeton Engineering and ODBI sites, a new mapping tool that allows researchers to peer deep into cells' inner compartments to watch and control ribosome assembly, shedding new light on the machinery responsible for making proteins.
ALT The words "New tool allows researchers to track assembly of cells' protein-making machines, image by Holly Cheng" with microscope image of pink and green globules
Denis LJ Lafontaine retweeted
RNase L cleaves most tRNAs in the anticodon loops into various tRNA-derived RNAs (tDRs) including 5'-tDRAla that shows a translation inhibitory effect. Some tRNAs are also cleaved in variable loops. bit.ly/3YTwlNq
Denis LJ Lafontaine retweeted
Excited to share our recent work, which addressed a mechanism by which the eukaryotic ribosomes increase the fidelity of mRNA translation than prokaryotic ribosomes through the eukaryote-specific tentacle-like ribosome structure. academic.oup.com/nar/article…
Denis LJ Lafontaine retweeted
A PhD position is available to decipher the modus operandi of ribosome-inactivating proteins at Maria Curie-Skłodowska University, Poland
🔬 Cryo-EM, biochemistry, structural biology
📅 Apply by July 31, 2024
🔗 euraxess.ec.europa.eu/jobs/3…
#CryoEM #Ribosome
translacore.eu/article/job-o…
Denis LJ Lafontaine retweeted
We are thrilled to share our exciting collaboration with @GreenLabJHMI , showing that RIOK3 specifically recognizes ubiquitylated human 40S ribosomes and mediates their degradation under amino acid starvation. We even observed the melting 40S! cell.com/molecular-cell/full…
Denis LJ Lafontaine retweeted
Charting the epitranscriptomic landscape across RNA biotypes using native RNA nanopore sequencing dlvr.it/THRzDd
Denis LJ Lafontaine retweeted
Translation UK 2025 is coming 😊
Looking to attend exciting meetings and training events in 2025? View our calendar, register your interest for a range events including Educational Research in the Biosciences and Translation UK 2025, and be notified when registration opens!
ow.ly/iYSt50UF35Y
ALT Attendees at one of our previous events
Denis LJ Lafontaine retweeted
A role for the kinetochore protein, NUF2, in ribosome biogenesis | Molecular Biology of the Cell molbiolcell.org/doi/abs/10.1… New paper from ty brown in the Baserga Lab! Fabulous collaboration with @KabecheLab ! @YaleMBB @YaleCancer.
Denis LJ Lafontaine retweeted
Online Now: Epitranscriptomic rRNA fingerprinting reveals tissue-of-origin and tumor-specific signatures dlvr.it/TGj9sL
Discover how unique ribosome fingerprints could revolutionize early cancer detection with non-invasive, portable scanners able to detect cancer with near-perfect accuracy. #RNA
#CancerResearch #EarlyDetection #Ribosome #Genomics #NanoporeSequencing science-tldr.com/news/riboso…
Denis LJ Lafontaine retweeted
Online Now: Structural dynamics of human ribosomes in situ reconstructed by exhaustive high-resolution template matching dlvr.it/TGXlng
Denis LJ Lafontaine retweeted
Amazing ribosomes and... incredible cytokines 😯👇
P-stalk ribosomes act as master regulators of cytokine-mediated processes: Cell cell.com/cell/fulltext/S0092…
Denis LJ Lafontaine retweeted
