Working at the interface of Chemistry and Biology to develop novel biomarkers and therapies for neurodegenerative diseases. RT =/= endorsement
Lausanne, Switzerland
Joined March 2018
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LashuelNeuroLab retweeted
Exciting news from the @LashuelLab @epflSV ! Introducing ClearTau, an innovative method and platform for reconstructing aggregates of the protein #Tau found in #Alzheimer's and other neurodegenerative diseases.
actu.epfl.ch/news/cleartau-a… #epfl
LashuelNeuroLab retweeted
Scientists at EPFL @LashuelLab have discovered a new mechanism that explains how proteins clump together and become sticky. This is one of the causes of neurological diseases such as Lou Gehrig's disease. - via @xpress_medical
medicalxpress.com/news/2023-…
LashuelNeuroLab retweeted
Seeding the aggregation of TDP-43 requires post-fibrillization proteolytic cleavage #ALS
New @hlashuel @lashuelLab @SenThangaraj
nature.com/articles/s41593-0…
LashuelNeuroLab retweeted
Parkinson’s and neurodegeneration stand @Hlashuel #PortesOuvertesEPFL – at Chavannes-près-Renens, Suisse
LashuelNeuroLab retweeted
Les scientifiques travaillent à améliorer notre compréhension des mécanismes qui régissent le climat de la Terre. Ne manquez pas les conférences du dimanche sur les enjeux climatiques lors des #PortesOuvertesEPFL go.epfl.ch/254096
LashuelNeuroLab retweeted
It’s all about perspective at #PortesOuvertesEPFL
LashuelNeuroLab retweeted
A word from the Dean of the School of Life Sciences, Andy Oates @OatesLab
LashuelNeuroLab retweeted
Finally able to share our latest work, just published! doi.org/10.1016/j.nbd.2023.1… We found a novel #caspase -2 cleavage site in #tau protein, and show that casp2 also processes D421. 1/3
LashuelNeuroLab retweeted
Pas encore de programme pour ce weekend? ➡️ Portes Ouvertes EPFL!
🔬 Plus de 200 activités
🎙️ Des speakers, avec notamment @FredCourant de l'@EspritSorcier
🎪 Des stands, spectacles, jeux, expositions, conférences et ateliers
Toutes les infos sur portes-ouvertes.epfl.ch/
LashuelNeuroLab retweeted
Excited to share our preprint, where we overcome the alterations caused by fluorescent labeling. We utilize deep learning to identify and analyze live, unperturbed protein aggregates from transmitted light images with 96% accuracy.
biorxiv.org/content/10.1101/…
LashuelNeuroLab retweeted
New @biorxivpreprint manuscript from @Hlashuel & collaborators suggests that targeted nitration of fibrils may represent an effective strategy to prevent the accumulation & spreading of pathology involving α-Syn fibrils of different morphologies/strains
biorxiv.org/content/10.1101/…
LashuelNeuroLab retweeted
Happy to have been able to collaborate with @LashuelLab @Hlashuel and lead author Dr. Sonia Donzelli on this exciting project now on bioRxiv! "Post-fibrillization nitration of alpha-synuclein abolishes its seeding activity and pathology formation in primary neurons and in vivo"
LashuelNeuroLab retweeted
Post-fibrillization nitration of alpha-synuclein abolishes its seeding activity and pathology formation in primary neurons and in vivo biorxiv.org/cgi/content/shor… #biorxiv_neursci
LashuelNeuroLab retweeted
When we think about communication between neurons, we often think about synapses. But as you can see in this week's #EM_Monday images, the cell body of neurons can come into contact with each other, and this contact area is huge compared to synapses. So do the neurons use...(1/n)
LashuelNeuroLab retweeted
How to use ChatGPT intelligently and ethically for academic purposes:
A collection of my 7 (viral) threads 👇
LashuelNeuroLab retweeted
Happy to share our last article in @NatureComms
We determined the #CryoEM structure of full-length hnRNPDL-2 fibrils, a human functional #amyloid associated with a rare muscular dystrophy, with @stericagno & M. Bolognesi
Key findings below (1/5)
nature.com/articles/s41467-0…
LashuelNeuroLab retweeted
Outsiders wouldn't understand the feeling one has during the weeks when you are expecting a decision on a manuscript. You know that at anytime the email could show up, and that it would either shoot you and your students to the heavens or get all of you depressed.
LashuelNeuroLab retweeted
This week's editorial @Nature is on large language #AI models, such as #ChatGPT, in science, confronting critical issues
nature.com/articles/d41586-0…
LashuelNeuroLab retweeted
The association of multiple (> 20 replicated) viruses exposure with neurodegenerative diseases, sometimes manifesting many years later (as occurred with Parkinson's and the 1918 influenza pandemic)
cell.com/neuron/fulltext/S08…
@NeuroCellPress @KristinSLevine @mike_nalls & colleagues
LashuelNeuroLab retweeted
Third patient death in lecanemab Alzheimer's disease trial described in new reporting from @cpiller a Science Magazine. This treatment-related death was not disclosed at the recent CTAD meeting, despite occuring in mid-September.
science.org/content/article/…
