Science is my love language. Exploring uterine remodeling in the Roberson Lab @ CU Anschutz. Joining UMich MCDB PhD program this fall!
Colorado, USA
Joined April 2024
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LeCaine Barker🥼🔬 retweeted
Congratulations to our postbac Naomi Calhoun, submitting her paper last week, a primer on WNT7A. @intlsocdiff @SocDevBio @MDAndersonNews
LeCaine Barker🥼🔬 retweeted
For #FluorescenceFriday sharing the fantastic work of postdoc Sarah McLarnon! A follow up to our '23 Development paper where we asked: Does precise vascular patterning matter for function and what happens after ischemic injury? The results were surprising! journals.physiology.org/doi/…
LeCaine Barker🥼🔬 retweeted
Cane toads can find their way home across long distances
go.nature.com/3XmE1a4
LeCaine Barker🥼🔬 retweeted
Lastly, meet Jenn, the McKey lab postdoc! Jenn received her PhD in neuroscience from @UMich , where she studied the properties of GnRH neurons & how they are altered in a mouse model of PCOS🧠. When she's not working, she's hiking☀️, reading📚 or watching sports⚽️🏈🏀 @jaime_jenn
LeCaine Barker🥼🔬 retweeted
My first Fluorescence Friday 😇
#FluorescenceFriday ! #FluorescentFriday #bioart #sciart #histoart #pathart #microscopy #stomach
LeCaine Barker🥼🔬 retweeted
Globally, millions of individuals are affected by endometrial / uterine disorders, yet the #endometrium and the role of its #cellular #heterogeneity in these disorders have been hugely understudied compared with other human tissues and diseases.
LeCaine Barker🥼🔬 retweeted
Some tightly packed small intestinal villi, I love the spacing.
#FluorescenceFriday #FluorescentFriday #bioart #sciart #pathart #histoart #microscopy
LeCaine Barker🥼🔬 retweeted
A rising superstar scientist from the Roberson Lab! Check out LeCaine's work on uterine remodeling! @CUAnschutz
On a high after a really exciting day of talking cool science with even cooler people. Looking forward to the rest of the weekend and learning more about this awesome community of brilliant minds☺️#scdb
LeCaine Barker🥼🔬 retweeted
It’s incredible how densely packed the cell is with organelles and other structures! Just seeing a talk from JLS which brought up this paper using fib-sem pubmed.ncbi.nlm.nih.gov/3461…
LeCaine Barker🥼🔬 retweeted
I'm European.
I recently visited the USA for the first time since 2018, hitting up Las Vegas and New York City.
What I witnessed left me stunned.
15 American oddities I still can't wrap my head around:
LeCaine Barker🥼🔬 retweeted
Academic struggling to write the well-overdue paper they are currently trying to finish.
Oil on canvas.
ALT Leonid Pasternak’s The Passion of Creation.
LeCaine Barker🥼🔬 retweeted
Mesmerizing kidney collecting ducts (white) for this #FluorescenceFriday. Nerves in cyan.
LeCaine Barker🥼🔬 retweeted
It’s just a tiny bottle.. It probably doesn’t smell that bad
Tiny Bottle:
ALT 2-mercaptoethanol bottle
LeCaine Barker🥼🔬 retweeted
This is an interesting idea: turning a cancer's drug resistance against it
These are growth curves of tumours in mice, treated with a drug (a tyrosine kinase inhibitor). The tumours initially shrink but they all - slowly but surely - become resistant:
This study aimed to convert this resistance into vulnerability, by supplying tumours with a plasmid that deliberately provides resistance to the drug - but also encodes a suicide gene
What this means is that tumours shrink initially as they're treated with the tyrosine kinase inhibitor, but then grow back - fast - as they start to express the resistance gene
This expands the pool of resistant cells, but also the pool of cells with the suicide gene - so when the suicide gene is switched on (purple arrow), the tumours regress:
Leighow et al: nature.com/articles/s41587-0…
