Senior Lecturer @UQ_EAIT. Bioprocess & bioplatforms for engineering blood & vessels🩸🧫🔬💻
Brisbane, Queensland
Joined June 2015
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Mark Allenby retweeted
🚨Job alert in theory/math devbio 🚨
I’m currently advertising postdoc positions to join my group. We’re building reaction-diffusion models to understand some of the crazy things embryos can do. We are based in a beautiful part of Scotland. Please share! abdnjobs.co.uk/vacancy/resea…
Mark Allenby retweeted
🚨 𝗡𝗲𝘄 𝗣𝗮𝗽𝗲𝗿 𝗔𝗹𝗲𝗿𝘁! 🚨Excited to share our latest work by @StphanePetrousk 🦴🦴 on macrophage mechanobiology
sciencedirect.com/science/ar…
Mark Allenby retweeted
This is a groundbreaking study for pericyte fans. We discovered the unique pericyte marker Higd1b which only labels pericytes without any off-target effect from other mural cells. @ATS_PC @AHAScience @vascularbiology
#Pericyte #PulmonaryHypertension
1/2
A subpopulation of Higd1b+ lung capillary pericytes
👉Migrate (w/o proliferation) to distal arteriole
👉Upregulate Vimentin
👉Acquire #SmoothMuscleCell identity (α-SMA, circumferential wrapping)
in🐭Hypoxic PH
2 spatially resolvable pericyte subsets🐭👤
1⃣Higd1b-hi Pdgfrb-lo
at parenchymal capillary▶️enriched in metabolic terms
2⃣Higd1b-lo Pdgfrb-hi
close to arteriole▶️cytoskeletal terms (?% ready to invest arteriole upon hypoxia😁)
Do pericyte-derived arteriolar mural cells have differential functions than those from proximal arteries?🤓
#SciArt
@Viniciodjperez @KeYuan_BCH @embojournal 2025
embopress.org/doi/full/10.10…
Mark Allenby retweeted
Epigenetics Update - Viscoelastic extracellular matrix enhances epigenetic remodeling and cellular plasticity go.nature.com/3ENVZMB
Song Li (UCLA) in Nat Commun
#Epigenetics #ECM #CellularPlasticity
---
Perfect for cancer, immunology, and aging; epigenometech.com
Mark Allenby retweeted
🚨New preprint from our #EDITLab, a joint effort from @S_Marzban (PhD in mathematics), Curtis Gravenmier (MD in Pathology), challenging the current "Cancer Stem Cell" hypothesis in ALL.
Our preprint
"Cell state transitions drive the evolution of disease progression in B-lymphoblastic leukemia"
We used a Markov model to estimate transitions between leukemic subpopulations, showing predictors of BCR::ABL1 status & MRD in B-ALL
#EDITLab
biorxiv.org/content/10.1101/…
Mark Allenby retweeted
Very happy and excited to share that this work is now published in @NaturePhysics !
rdcu.be/eigWi
@sciences_UNIGE @UNIGEnews @IP_Paris_ @Polytechnique
Mark Allenby retweeted
New research on aortic valve stenosis (AVS) highlights PTEN's role in preventing myofibroblast activation and promoting quiescence in valvular interstitial cells. This could be a potential target for AVS treatment. #AVS @AnsethGroup
Read more: doi.org/10.1002/adbi.2024005…
Mark Allenby retweeted
It’s out! In this study, we investigated the response of endothelial cells to microgrooves and discovered different mechanisms for single cells and monolayers. doi.org/10.1002/admi.2022024…
A thread for more details 🧵:
Mark Allenby retweeted
Published in @CellCellPress: thrilled to contribute a bit to this amazing work led by @wang_yingxiao on developing “EchoBack” CAR T cells that respond to and can be tracked by ultrasound—enabling noninvasive control and imaging of cell therapies!! cell.com/cell/abstract/S0092…
Mark Allenby retweeted
I can't get over these 3D spatial images in the latest preprint from @sorger_peter @ajitjohnson_n et al.
The preprint is a roadmap on how to conduct 3D cyclic immunofluorescence using "thick" archival sections and precisely map cell-cell interactions
biorxiv.org/content/10.1101/…
Mark Allenby retweeted
This is important.
How to reduce feelings of physical and mental fatigue during your PhD.
Mark Allenby retweeted
Join the International Data Week October 13-16 2025 in Brisbane! Under the theme "Data for Positive Change: Empowering Communities and Advancing Research," this event will unite global experts to explore pioneering data solutions. #DataInnovation #IDW2025 idw2025.org/
Mark Allenby retweeted
CHOIR is officially published @NatureGenet. No more arbitrary decisions in clustering. Add this to your single-cell toolbox - it will save you so much heart ache. And now it can scale to millions of cells. Compliments of the very talented @cathrine_sant.
CHOIR is now online @NatureGenet! CHOIR is a new clustering method for single-cell data that evaluates whether clusters represent statistically distinct cell populations. CHOIR scales to millions of cells and works with single-/multi-omic data of any type!
nature.com/articles/s41588-0…
Mark Allenby retweeted
Excited to share our latest paper in @Nature
in which we developed a microvasculature-on-chip system to learn more about how clots in the context of inflammation "get better" over days to weeks to months. Thanks to @ahmetfcoskun collaborating with us! nature.com/articles/s41586-0…
Mark Allenby retweeted
The #tidyplots paper shares what went into shaping the package — including the controversial bits 😏
doi.org/10.1002/imt2.70018
#rstats #dataviz #phd
Mark Allenby retweeted
* New Nature Paper Alert *
Here we introduce a hydrogel-based thromboinflammation-on-a-chip model coupled with multiplexed RNA fluorescence in situ hybridization in combination
Link: lnkd.in/e8V67HmB
Fruitful collaboration with Prof. Wilbur A. Lam and Dr. Yongzhi Qiu
Mark Allenby retweeted
Extremely happy to share our study on the regulation of HSCs in the context of myocardial infarction! Driven by two amazing scientists in my lab - Jasmin and Maricarmen and co-led with the awesome cardiologist Timo! Huge thanks to all our collaborators 👏🏻👏🏻 @mpi_ie @ETH_en
New publication by the @Nina_CabezasW lab & @Uniklinik_Fr / @ETH
A vitamin A metabolite may offer a targeted therapeutic strategy for heart attack patients by regulating HSCs to minimize excessive inflammation and preserve long-term heart function.
ie-freiburg.mpg.de/6031982/n…
ALT A vitamin A metabolite can regulate the activity of hematopoietic stem cells and thereby reduce inflammation after a heart attack, ultimately improving heart function in the long term.
Mark Allenby retweeted
Not every organ ages the same🤠
Skull💀Bone Marrow (incld Vasculature & VEGFA+ LSK #HematopoeticStemaProgenitorCell)🐭 Expands with age
Skull BM even exhibits⏫age-dependent contribution to circulating leukocytes🥸 (photoconversion in Vav-cre;Rosa26-KikGR 🐭)
Moreover, skull BM expands acutely to systemic (Pregnancy, #ChronicMyeloidLeukemia, #ParaThyroidHormone) & local insults (Ischemic stroke/tMCAO)
#SciArt
@bikohcello @vishalmkrishnan @ralfhadams @Nature 2024
nature.com/articles/s41586-0…
Mark Allenby retweeted
💡 New research out of @PittDeptofMed uncovers novel mechanisms by which TLR4 orchestrates the complex interactions between macrophages and both #EndothelialCells (ECs) and lymphatic ECs during #sepsis. | @CommsBio
🔗 go.nature.com/4iu9Xlm
