@MED_COMPLEX

I'm the Mediator Complex but you can call me MED. I'm essential for gene transcription & my best friend is the RNA pol II. And I have a head, a body & a tail.

Joined September 2012
  • Tweets2K
  • Following229
  • Followers984
119Media
TFs really like me too much
Andrey Feklistov@AndreyFeklistovOct 13
Excited to share a preprint on the structural mechanism of transcriptional activation by human Mediator, studied using integrative structural modeling. Many thanks to Lacra Bintu @BintuLacra for helpful discussions! biorxiv.org/content/10.64898… @generegulation @MED_COMPLEX
5
261
I am a hot target
Will Chen@wchenomicsOct 21
Thrilled to share my freshly "baked" Baker lab paper. We took a bottom-up approach to designing transcriptional regulators. Instead of relying on natural activation domains, we designed compact proteins that recruit specific cofactors. Activators for now, repressors to come!
1
5
757
A mechanism of synergistic Mediator recruitment in RNA polymerase II transcription activation revealed by single-molecule fluorescence dlvr.it/TPB1Mt
16
85
6,897
MED_COMPLEX retweeted
ASBMB@ASBMB24 Oct 2025
Inside @JbiolChem: New research sheds light on the fundamental mechanism of gene regulation by the Mediator complex. ➡️Read "N-terminal half of MED14 is critical for Mediator-RNA polymerase II interaction and the resulting transcription" here: jbc.org/article/S0021-9258(2….
MED14-NTD is necessary for a full recovery of basal and activated (p53) transcription.

ALT MED14-NTD is necessary for a full recovery of basal and activated (p53) transcription.

4
8
1,094
It was a pleasure to present @cshlmeetings Mechanisms of Eukaryotic Transcription conference. Watch my summary of how gene expression can be stopped using the link below. Thanks to the audiovisual team at @CSHL for recording. lnkd.in/e5zxs24M
4
16
1,367
Demonstration of the crucial role of MED14 in fetal #organogenesis and elucidation of the mechanistic details underlying a potential link between #VACTERLAssociation and the Mediator complex. #DiseaseModel #OpenAccess: sciencedirect.com/science/ar…
1
1
316
MED13L Pathogenic Missense Variants Impair Protein Stability and Interaction, Underlying Diverse Clinical Outcomes cell.com/hgg-advances/fullte…
5
696
Structural insights into human Pol III transcription initiation in action by @xu_lab #cryoem nature.com/articles/s41586-0…
2
7
808
Online Now: Mediator regulates transcriptional termination through crosstalk with pre-mRNA 3′ end processing factors dlvr.it/TL2Qrq
1
13
67
6,012
MED_COMPLEX retweeted
Zihan Xu@xu_zxu5 May 2025
We discussed how perturbing the Mediator Complex, a key gene expression regulator, reshaped cellular phenotypes. Some perturbations induced autonomous dedifferentiation, while others led to drug-resistant states. Interestingly, their effects aligned with the complex’s structure!
1
1
11
771
The first #cryoEM structure of a Mediator complex subunit in complex with a transactivation domain nature.com/articles/s41467-0…
2
16
941
nature.com/articles/s41467-0…

Structural basis of human Mediator recruitment by the phosphorylated transcription factor Elk-1

Nature Communications - The Mediator complex subunit MED23 contributes to transcriptional activation by the phosphorylated transcription factor Elk-1, in response to Ras-MAPK signalling. Here, the...

nature.com
6
1
31
1,945
What is the role of Med23 in brain development and ADHD pathophysiology? Learn about the consequences of Med23 knockout and how methylphenidate may ameliorate the resulting ADHD-like behaviors nature.com/articles/s41386-0…

Central Med23 deficiency leads to malformation of dentate gyrus and ADHD-like behaviors in mice

Neuropsychopharmacology - Central Med23 deficiency leads to malformation of dentate gyrus and ADHD-like behaviors in mice

nature.com
4
8
926
There is a new platform, Sci-Net (sci-net.xyz) where researchers can help each other by providing paywalled papers. The platform builds upon Sci-Hub meme token $scihub to reward active members.
101
818
62
2,884
268,276
The basic helix-loop-helix transcription factor TCF4 recruits the Mediator Complex to activate gonadal genes and drive ovarian development biorxiv.org/content/10.1101/… #biorxiv_devbio
1
314
MED_COMPLEX retweeted
Feng Zhang
@zhangf27 Feb 2025
We are excited to report the discovery of TIGRs, a widely-occurring RNA-guided system found in bacteria and their viruses. TIGRs consist of a peculiar repeat region which is transcribed into RNA and processed into multiple guide RNAs to direct TIGR-associated proteins to their DNA targets. science.org/doi/10.1126/scie…

TIGR-Tas: A family of modular RNA-guided DNA-targeting systems in prokaryotes and their viruses

RNA-guided systems provide remarkable versatility, enabling diverse biological functions. Through iterative structural and sequence homology-based mining starting with a guide RNA-interaction domain...

science.org
26
264
33
1,272
152,551
A dual interaction between RSV NS1 and MED25 ACID domain reshapes antiviral responses biorxiv.org/cgi/content/shor… #biorxiv_pathol
1
4
409
Real-time visualization of reconstituted transcription reveals RNA polymerase II activation mechanisms at single promoters biorxiv.org/cgi/content/shor… #biorxiv_biochem
9
20
1,714
nature.com/articles/s41586-0… (1/n) Ever wonder how transcription factors locate, "invade," and activate their enhancers during cell fate acquisition? 🧬🚀Check out our latest collaborative work with the Soufi lab, now published in @Nature!

Nucleosome fibre topology guides transcription factor binding to enhancers

Nature - Motif grammar on nucleosome fibres acts as signpost elements, directing TF combinatorial binding to enhancers.

nature.com
18
75
3
300
29,317
Ever wondered how transcription choreographs histone modifications? Our work reveals the basis of co-transcriptional H3K36me3 by SETD2. We visualize how a histone writer coordinates with the transcription machinery! This is the magnus opus of @MarkertJon tinyurl.com/setd2
12
128
5
498
76,009
Load more