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Official account for Dr. Lynne Maquat's Lab at UR. Nonsense-mediated mRNA decay. Translational control. Transcriptional regulation. We love everything RNA!

University of Rochester
Joined May 2022
Photo by Maquat Lab (@MaquatLab)Photo by Maquat Lab (@MaquatLab)Photo by Maquat Lab (@MaquatLab)
We’re thrilled to partner w/ @ualbany to form a NYS Center of Excellence in RNA research! Co-led by @MaquatLab @wagnerlab_rna, we'll team up to develop RNA-based therapies & train scientists. Huge thx to @HarryBBronson for his support #URochesterReesarch urmc.info/1yr
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Katalin Karikó and Drew Weissman – awarded the 2023 #NobelPrize in Physiology or Medicine – discovered that base-modified mRNA can be used to block activation of inflammatory reactions and increase protein production when mRNA is delivered to cells.
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Cheers to RNA biologist Lynne Maquat for officially receiving the Gruber Genetics Prize @Genetics2023 in Australia for her work on nonsense-mediated mRNA decay. Proud to have you represent @UofR on an international stage! #URochesterResearch @MaquatLab urmc.info/15L
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Study in @Nature details a new algorithm to find the most stable, efficient mRNA sequence to use in vaccines. Dave Mathews + @lhuang3 show optimal mRNA sequences lead to ⬆️ protein production, improved immune response @UofR @OregonState #URochesterResearch urmc.info/Wa
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New #URochesterResearch in @ScienceMagazine upends the idea that #CRISPR mounts its defense only by cutting RNA/DNA. It found a Cas protein works w/ a membrane protein 👇to stop infection in bacteria. What?? @mitchellrayoco1 @arica_vanderwal @kellogg_liz   urmc.info/Vy
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That’s a wrap of #2023RNASymposium! An event for the books showcasing a long standing collaboration between these amazing RNA scientists from @TheRNAInstitute & Univ of Rochester Medical Center @BerglundLab @Wagnerlab_RNA @belfort_lab @MaquatLab @begley_lab Dave Mathews
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Using guide RNA, scientists found a way to make some genetic mutations "invisible." The findings in @MolecularCell are helping the search for treatments for #CysticFibrosis & #neurofibromatosis Read: urmc.info/QA @CF_Foundation @GilbertFamilyFd #URochesterResearch
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A big congrats to Lynne Maquat for winning the 2023 Gruber Genetics Prize for her discovery of nonsense-mediated mRNA decay (NMD) in humans! She shares the prize w/ Allan Jacobson from @UMassChan 👏👏 #URochesterResearch #GruberPrize @The_Gruber_Fdtn @Genetics2023 @GeneticsGSA
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Registration for #CSHAsia meeting on the Now and Future of #RNATherapeutics (csh-asia.org/?content/1309) at Awaji 🇯🇵 in June2023 is now opened! Abstracts submission by April 14! #RNA #mRNA #siRNA #antisense #RNAtranslation #Geneediting #liposome #RNADrugs #mRNAvaccines
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Our next Dean’s Lecture Series event is happening Monday, Dec. 12 and features our very own RNA expert Lynne Maquat, Ph.D. (@MaquatLab). Details here: urmc.info/DS.
BREAKING NEWS: The 2022 #NobelPrize in Physiology or Medicine has been awarded to Svante Pääbo “for his discoveries concerning the genomes of extinct hominins and human evolution.”
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Grad students and postdocs: Check out this conference designed to help women in higher education push through barriers to reach their career goals. Hosted by @UofR's Institutional Office of Equity & Inclusion ➡️bit.ly/3Be1LRQ
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Celebrating 50 yrs of Joan!!! 🥳 Awesome to see so many trainees and friends 😁.
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Less than a week is left for the deadline! We assembled an impressive line of keynote @CChengLab @HentzeTeam @MaquatLab and invited speakers @SaharMelamed @BenhamouRaphael @assaf98973488 @AldemaSasChen, Dan Bar-Yaakov, and Boris Slobodin Register! iias.huji.ac.il/event/rna-co… #RNA
(1/5) We are pleased to inform you that the registration for the Israeli RNA Society Meeting in memory of Prof. Yossi Sperling is now open!!! We have changed the date to incorporate the meeting with The 28th Advanced School in Life Sciences: Novel roles for RNA in Biology&Therapy
I just noticed that @MaquatLab and @HentzeTeam are keynote speakers at the @RNA_ISR conference. iias.huji.ac.il/event/rna-co… What fun! Abstract submission deadline is next week, Aug 15th
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Its finally officially out! Collection of great #lncrna reviews in special issue of Mammalian Genome link.springer.com/journal/33… great job from all the authors and fellow editors @carninci @MaquatLab @SValadkhan
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Scientists discover that the AKT signaling pathway, important for cell survival and growth, is an unexpected effector of nonsense-mediated mRNA decay (NMD). Upregulation of AKT signaling contributes to hyperactivation of NMD. @MaquatLab ow.ly/VSeL50Ju5Tp
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Work from @rodriguezmol on the role of Mpe1 in mRNA 3' end processing is now out in @MolecularCell ! This was a team effort including @FJ_OReilly @FagarasanHolly @EleanorSheekey @RappsilberLab @ERC_Research @MRC_LMB
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Recent technical advances in the study of nucleic acid modifications dlvr.it/SB23Tf
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