Marc Macaluso (@MarcAMacaluso) header
Marc Macaluso (@MarcAMacaluso) profile picture

Beauty makes little things bigger than big things Founder, TMW Longevity. Blacklist awarded film writer. Former tech founder.

Los Angeles
Joined October 2012
We just published a critical review of the KETO-CTA study — the first study to examine coronary plaque progression in Lean Mass Hyper-Responders (LMHRs) on a ketogenic diet. Here’s why we believe the study’s results have been seriously misrepresented. 1/14
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if you find this to be unbelievable, it’s because it’s _all known to be false_ or at best weakly true in cell lines but not people smh
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Marc Macaluso retweeted
A democracy can only last 200 years. At least, that’s according to 18th-century historian Alexander Tytler. He claimed democracies always follow a predictable pattern and are doomed to end in servitude…🧵
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Marc Macaluso retweeted
Prophetic words from Alexander Hamilton to George Washington in 1792 — as apt and timely today as they were over 230 years ago.
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Sad sign of the times this even needs to be said, but headlines claiming @Harvard researchers developed a chemical approach to reverse aging are not true. Nobody has a drug to reverse aging. @elonmusk and everyone else, please don’t start taking anything based on this nonsense
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Marc Macaluso retweeted
Just worry about making the best decisions possible, recognizing that no matter what you do, most everyone will think you're doing something-- or many things-- wrong. It is human nature for people to want you to believe their own opinions and to get angry at you if you don't, even when they have no reason to believe that their opinions are good. So, if you're leading well, you shouldn't be surprised if people disagree with you. The important thing is for you to be logical and objective in assessing your probabilities of being right. It is not illogical or arrogant to believe that you know better than the average person, so long as you are appropriately open-minded. In fact, it is not logical to believe that what the average person thinks is better than what you and the most insightful people around you think, because you have earned your way into your higher-than-average position and you and those insightful people are more informed than the average person. If the opposite were true, then you and the average man shouldn't have your respective jobs. In other words, if you don't have better insights than them, you shouldn't be a leader-- and if you do have better insights than them, don't worry if you are doing unpopular things. So how should you deal with your people? Your choices are either to ignore them (which will lead to resentment and your ignorance of what they are thinking), blindly do what they want (which wouldn't be a good idea), or encourage them to bring their disagreements to the surface and work through them so openly and reasonably that everyone will recognize the relative merits of your thinking. Have the open disagreement and be happy to either win or lose the thought battles, as long as the best ideas win out. I believe that an idea meritocracy will not only produce better results than other systems but will also ensure more alignment behind appropriate yet unpopular decisions. #principleoftheday
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In the not too distant future the far left and the far right will be one, unified in their irrational desire to overthrow the institutions of America and Europe. From antifa to the woksters on the left, and from white nationalists to the post-truth party on the right. 1/2
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The only solution for rational stability will be the technological state. This is all being brought-on by the technological state. The medium is the message. 2/2
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Marc Macaluso retweeted
I hosted @BilyanaLilly recently to discuss her research and opinions on Russian information warfare and cybersecurity. We spoke further about Bilyana's academic and industry background and, more recently, her work with the @WarsawForum. christophersweat.substack.co…
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My god. @BarackObama has gone full MAGA, just like @elonmusk!
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Marc Macaluso retweeted
1/Large language models like Galactica and ChatGPT can spout nonsense in a confident, authoritative tone. This overconfidence - which reflects the data they’re trained on - makes them more likely to mislead.
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SCOOP: Net energy gain in a fusion reaction has been a holy grail in science for decades. Now I’m told US scientists have done it. A massive breakthrough with revolutionary potential for clean power. US Energy Secretary to hold a press conference Tuesday on.ft.com/3PgDdya
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Marc Macaluso retweeted
The one thing you can never do as a journalist is deceive your readers. Among all the other nonsense that went on tonight we have a great example of it here. Taibbi portentously announced that the Biden Team had sent an order to Twitter to delete Tweets and it had been "handled."
Replying to @mtaibbi
8. By 2020, requests from connected actors to delete tweets were routine. One executive would write to another: “More to review from the Biden team.” The reply would come back: “Handled.”
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With Trump back on Twitter, it’s a good time to watch this Jan 6 hearing. It covers each of Trump’s tweets that day, including those that have been deleted, and features multiple Trump WH staff describing his inexcusable conduct during the violence. january6th.house.gov/legisla…
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"Life is as much a Gabriel Garcia Marquez novel as it is a Taoist poem. It is as complex, meandering, and inexplicable, and is it strikingly simple and obvious." enmeshed.substack.com/p/enme…
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I invite everyone to read my first post of my new substack, EnMeshed.
I'll be interviewing Jonathan Woetzel, founder of McKinsey China, tonight to get the inside story of what happened over the last 35 years, and discuss the new geometry of the world order. joinclubhouse.com/event/mWJY…
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If the core DNA of human motivation is to care for and protect itself, and its offspring, every aspect of civilization can be seen as an evolving materialization of that instinct. The full maturity of this DNA will not be complete until it is universally achieved. 1/5
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AI could subvert this evolution somehow by instantiating a dominating system that undermines the substrate processes of our evolution by locking our materializing efforts into a virtual domain that ultimately stagnates true evolution... 4/5
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...or climate change and nuclear war could destroy us. Optimistically, these “dangers” could further activate our core DNA and instigate greater achievements in the materialization of potential…universally. 5/5
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