Half Sardinian-German, interested in GI tract, stem cell niche, IBD, circadian rhythm, microbiome, aging.Amateur cook, dog dad, music aficionado #newPI, 1st gen
Mannheim, Baden-Württemberg
Joined June 2016
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Glad to announce I will be joining the Department of Medicine II in Mannheim as a junior group leader in January 2023! This is finally a dream come true, the child in me who wished to be a scientist feels very satisfied. I am extremely grateful to all my previous mentors.
Matthias Schewe retweeted
Our @Nature paper is out!
It's been known for a while that long-term dietary habits can affect how our immune system behaves. But what about much briefer changes in diet?
In mice, we found that even a few days of dietary change (think cheat days...or perhaps salad Sundays) at the onset of inflammation can profoundly alter disease severity and establish lasting inflammatory memory in tissues, even after the diet changes back.
nature.com/articles/s41586-0…
This work was led by two extraordinarily dedicated and inexhaustible members of our lab: former graduate student @OwenJ457 and former technician John Tayeri. It was also an exercise in collaborative science as many labs @UCSF and @Stanford came together to bring this over the finish line - special thanks to @gardnerlabUCSF, @Molofsky_lab, @alexis_combes, @Treg_Mike. Deeply grateful to everyone who contributed!
Matthias Schewe retweeted
Thrilled to share our latest publication in @NatureComms !
Can the intestine remember a previous injury?
We show that intestinal injury leaves a lasting transcriptional and epigenetic imprint that primes the tissue for enhanced regeneration.
nature.com/articles/s41467-0…
Matthias Schewe retweeted
Findings in this study (@cellhostmicrobe) identify Gemella morbillorum as a candidate onco-pathogen in #ColorectalCancer that uses multiple mechanisms to disarm the #intestinal barrier and trigger genotoxicity.
#OpenAccess🔗: bit.ly/4icn1gh
Matthias Schewe retweeted
Very excited to share our new paper, published in Cell!
We found that caloric restriction (CR) in mice reduces somatic mutation burdens across the genome, and that this effect has some surprising features.
🧵👇
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Matthias Schewe retweeted
How do lipids influence aging?
We find that membrane lipid composition impacts neural stem cell aging and 'rejuvenation'!
HUGE congratulations to @xiaoaizh on her paper just published at @ScienceAdvances!! 🤩🍾
And a big thank you to all our collaborators!
A thread 🧵...
Matthias Schewe retweeted
New study from our lab: a ketogenic diet has opposite effects on intestinal tumors in mice — accelerating them in the small intestine, suppressing them in the colon. Neither effect requires ketones — dietary lipid content drives both. rdcu.be/ftWig
Chek out this amazing work!
Excited to share our new @CellStemCell study from @kochinstitute @MIT: "Lineage plasticity driven by GATA6 loss fuels colorectal cancer metastasis." Led by two former lab postdocs—Saori Goto (first author) & Nori Goto, now running his own lab. kwnsfk27.r.eu-west-1.awstrac…
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Matthias Schewe retweeted
Why do we age? Evolution may hold the answer.
Because natural selection weakens later in life, genes that boost early survival and reproduction can persist even if they contribute to aging and disease decades later. New advances in genetics and multi-omics are helping uncover why lifespan varies so dramatically across species—and how we might extend healthspan. #Aging #Longevity #Genetics
nature.com/articles/s41576-0…
Matthias Schewe retweeted
Disease causing mutations in each of these 11 genes are implicated in at least three different chronic diseases or lifespan in humans. #Aging #Longevity #Genetics
nature.com/articles/s41576-0…
Matthias Schewe retweeted
Chronic stress does more than affect mood—it may accelerate biological aging. Persistent glucocorticoid exposure disrupts autophagy, mitochondrial function, and immune resilience, promoting many hallmarks of aging linked to sarcopenia, neurodegeneration, metabolic disease, and frailty. #Aging #StressBiology #Longevity
sciencedirect.com/science/ar…
Matthias Schewe retweeted
Excited to share our new study using engineered immune proteins to quench inflammation in aged brains!!
Congratulations to @Paloma_Negredo and team!
Fantastic collaboration with several labs - Chris Garcia's lab, @rsaxton_, @theRafLab, @wysscoray, and @VilledaLab!
Matthias Schewe retweeted
Linus Pauling is the only person to have received two unshared Nobel Prizes - in chemistry and peace.
He used quantum mechanics to understand and describe chemical bonding. Later he campaigned vehemently against nuclear weapons and spearheaded a petition to ban nuclear testing.
ALT Linus Pauling standing next to a chemical model.
Matthias Schewe retweeted
Dietary urbanization destabilizes host-gut microbiome homeostasis and informs precision nutrition for human health dlvr.it/TP7yr2
Matthias Schewe retweeted
If you are working on cellular plasticity, don't miss out this rare FASEB conference opportunity in May with fantastic speakers lineup!
Abstract submission deadline: 3rd March
We still have slots for selected short talks! Don't miss out the early bird registration 👇
FASEB's first conference of 2025 is the first to tackle cellular plasticity and our first to take place in mainland Asia! Join organizers @stephaniema912, @VivianLiLab, and @JustinLathia with keynote speaker @HansClevers for an amazing and packed conference full of new research, lectures, and networking. Save your space: hubs.ly/Q0345R1q0
Matthias Schewe retweeted
Wow. USAID website has been brought back online for the first time in days — only to include the message that all USAID staff worldwide will be placed on administrative leave
Matthias Schewe retweeted
Black History Fashion Fact on the first day of Black History Month: Thomas Jennings was the first African American to win a patent, which he received in 1821 for the invention of “dry scouring” otherwise known as dry cleaning. Newspaper photo from March 13, 1821 New York Gazette.
ALT Photograph of American inventor and abolitionist Thomas L Jennings, taken first half of 19th century. Jennings is a thin Black man in an informal 3 piece suit.
![LETTERS PATENT Being granted under the GREAT SEAL OF THE UNITED STATES OF AMERICA UNTIL THOMAS LJ ENDINGS, TAl-lor, 61 Masau Street, New-York, for his Invention of Dry Scouring Clothes, ond Woollen Fabrics in general, so that they keep their original shape, and have the polish and apppearance of new, inform the public that he is ready to execute all Orders enrusted to him in the above line, on reasonable terms, He also Alters and Repairs Gentlemen's Clothes in the neatest manner, being regularly brought up to the T'ailor's business, aud practing in this city the last 11 years. He aiso removes slains from Cloth. N.B. Directions will be given how Clothes may be kept in the condition they are delivered. Gentlemen's Clothes purchased-Mi- litary Clothes and Accoutrernents soll on Commission, on moderate terms. m8 ]w](https://pbs.twimg.com/media/GiwQdz_XAAA15LU.jpg?name=orig)
ALT LETTERS PATENT Being granted under the GREAT SEAL OF THE UNITED STATES OF AMERICA UNTIL THOMAS LJ ENDINGS, TAl-lor, 61 Masau Street, New-York, for his Invention of Dry Scouring Clothes, ond Woollen Fabrics in general, so that they keep their original shape, and have the polish and apppearance of new, inform the public that he is ready to execute all Orders enrusted to him in the above line, on reasonable terms, He also Alters and Repairs Gentlemen's Clothes in the neatest manner, being regularly brought up to the T'ailor's business, aud practing in this city the last 11 years. He aiso removes slains from Cloth. N.B. Directions will be given how Clothes may be kept in the condition they are delivered. Gentlemen's Clothes purchased-Mi- litary Clothes and Accoutrernents soll on Commission, on moderate terms. m8 ]w
Amazing science!! but knowing the lab not surprised at all😎 A must read. – at Frankenthal (Pfalz), Deutschland
Our new #organoid #organchip #coculture review. Congrats @_KamilMoskal, @Yeseul700lee, Luisa Siegert, Nimisha Khurana from @EMIL_DKFZ @DKFZ!
Cool experience connecting the dots between in organotypic models and microbiome with @HansClevers and @EranElinav!
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Matthias Schewe retweeted
Read the #GUTOnline paper by @vidya87_ & @Bradleyomics et al on
"Genetic variation at 11q23.1 confers colorectal cancer risk by dysregulation of colonic tuft cell transcriptional activator POU2AF2" via
bit.ly/3ZBZZY9
@RubyTOsborn @ccgg_edinburgh #ColorectalCancer
Come join us and do fun science! linkedin.com/posts/matthias-… – at Mannheim, Germany
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