TLDR: The @MinicircleDNA follistatin gene therapy increased my VO2 max by as much in a week as 3 months of training. I'm sharing this due to the doubt I've seen both from anti-tech media & my skeptical, well-intentioned friends like @yashgaroth & @s_r_constantin. I'm not qualified to evaluate the science & I don't have N=many data, but I can speak as an N=1 who saw significant performance impact from this treatment @farbood, @bryan_johnson, @michaelmalice & others got at @ProsperaGlobal. My first treatment was in 2023, and I was expecting mainly muscle growth effects. A week later, my cardio performance improved drastically, in a way that was both unexpected & subjectively unmistakeable: one day I was suddenly running almost 50% longer with the same effort. I later participated in their reversibility study to turn off the gene therapy, and of course afterwards I got the therapy again. The second time, I decided to collect VO2max data before, during, and after. From the baseline first row, you can see that V02max increased by 4.8 ml/kg/min in 2 months of training; 4.3 in one week after the therapy, and another 3.6 in 3 months of training. These differences exceed the expected 2%-5% per-trial variation of 1-3 ml/kg/min. I get the skepticism (it's a new treatment and there's little public data), and I think it's healthy to have doubt and pushback from those with high integrity like Max & Sarah (though I could do without the clickbait tech-hating MSM). But when I read things insisting this therapy can't do anything meaningful, I know from direct personal experience that this is simply not true. I encourage anyone else doing this therapy to collect similar data and report back - my DMs are always open 🙏.

Congrats to @KennethBogner, @GregForMontana, @NiklasAnzinger and @adamgries for passing #SB535, which creates a regulatory framework for Montana physicians to prescribe experimental treatments which have passed FDA Phase 1 (safety) trials. IMO the United States & EU are victims of their own success after having scaled to such massive sizes. They get economies of scale in production and trade thanks to huge internal markets, while suffering from the diseconomies of scale that come with huge governments. The massive regulatory burdens from distant lawmakers in DC/Brussel retard innovation; IMO it’s time to rediscover the benefits of state-level experimentation. Super excited for the first licensed centers to be built. Congrats again to all involved.