Natalie Edner retweeted
We are recruiting people with #type1diabetes for a new clinical study at the Royal Free Hospital London. Feel free to reach out using contact details on poster below to learn more ⬇️
#Type1DiabetesGrandChallenge #BreakthroughT1D #DiabetesUK @RoyalFreeChty @BT1DUK @DUK_research
As previously described, we observed a positive correlation between S1 IgG titre (and strength of nAbs) and circulating follicular helper T cells (cTfh) expressing activation markers such as ICOS and CD38. Interestingly, this correlation was inverse when we looked at TIGIT+ cTfh.
We also found that TIGIT+ and TIGIT- cTfh are Tfh1 and Tfh17 skewed, respectively, and that TIGIT- cTfh express more CD40L following activation. Given the importance of CD40L in germinal centre reactions this may explain the superior ability of TIGIT- cTfh to provide B cell help.
Natalie Edner retweeted
Still time to apply for the Research Technician post in our lab!
ucl.ac.uk/work-at-ucl/search…
Natalie Edner retweeted
Postdoc position available in our lab! Are you interested in self-reactive T cells & how costimulatory pathways shape their fate? Project uses in vivo models, spectral cytometry & sequencing approaches. Deadline 6th March.
euraxess.ec.europa.eu/jobs/1…
Natalie Edner retweeted
Our new review on the Immunology of #Type1Diabetes now out in @NatRevImmunol – really important area for understanding and maximising immunotherapies. Kevan Herold @Bruskolab Thomas Delong, Ana Luisa Perdigoto, Noah Biru @DUK_research @JDRFUK @iit_ucl
nature.com/articles/s41577-0…
ALT Cartoon of immune cells: T cell phenotypes associated with B cell help are linked to type 1 diabetes
Natalie Edner retweeted
New review from Lina Petersone & I highlights recent findings on IL-21 and germinal center biology. Such an interesting cytokine!
dx.doi.org/10.1093/intimm/dx…
Natalie Edner retweeted
We are v proud to finally share this!
Following @NatalieEdner's seminar (@LucyWalkerlab) in series 1, we were invited by @IMTadvances to write an article to review our discussions online
Thank you for tuning in to both series!
Go give it a read now🙌🤓
doi.org/10.1093/immadv/ltad0…
Natalie Edner retweeted
Really looking forward to Black in Immuno Week 2023! The past events have been superb. Excited for the Autoimmunity/Allergies talk! #BIIW2023
Black in Immuno Week 2023 is coming Nov 9-11!
This year we’re focusing on “Immune Systems in a Changing Environment”, with a program of speakers, panels, workshops, and networking events.
Don’t miss out! Register at tinyurl.com/BIIW2023
#BIIW2023
ALT Detailed flyer for Black in Immuno Week 2023: Immune Systems in a Changing Environment. Nov9-11, 2023.
Natalie Edner retweeted
If you want to see fantastic images like THIS, be sure to catch our next seminar with Lina Petersone to discuss the role of IL-21 on germinal B cell development!
📅 Thursday 12th October, BST
📍 ucl.zoom.us/my/ligonlinejour…
Our October cover shows a confocal image of a germinal center compartment in an IL-21R−/− mouse immunized w/ sheep RBCs 6 d earlier and stained for BCL6, CD35, CD3, and IgD. From Petersone et al (bit.ly/467yVka).
Read JEM October Issue: bit.ly/3t7RYMO
Natalie Edner retweeted
BSI Triggers of Autoimmunity online meeting 26th Oct! Speakers include David Wraith @cameron_wraith Dana Orange @danaorange Pia Leete @PiaLeete Alberto Ascherio Simon Milling @s_milling Claudia Mauri @Mauri_group Ignacio Sanz. Abstract deadline 22 Sept.
immunology.org/events/trigge…
Natalie Edner retweeted
Just a few days left to apply for the Research Technician post in our lab! @iit_ucl
ucl.ac.uk/work-at-ucl/search…
Natalie Edner retweeted
New study led by Lina Petersone now in @JExpMed . Cytokine IL-21 from Tfh promotes germinal center (GC) responses & is overproduced in #autoimmune diseases. We found IL-21R deficiency led to a GC dark zone defect in autoimmune and immunisation settings 1/4 doi.org/10.1084/jem.20221653
Natalie Edner retweeted
Petersone et al. @LucyWalkerlab @iit_ucl investigate IL-21–dependent germinal center (GC) regulation and reveal key roles for IL-21 in promoting light zone GC B cell selection and controlling dark zone GC B cell proliferation by upregulation of cyclin D3. bit.ly/3pLquLO
Natalie Edner retweeted
Thrilled to have Her Majesty The Queen visit @iit_ucl to hear about the type 1 diabetes research in Professor Lucy Walker’s lab. Her Majesty is president of JDRF who fund ground-breaking research aiming to cure this condition. @uclnews @UCLInfectImm
ucl.ac.uk/news/2023/jun/hm-q…
ALT The Queen and Professor Walker wearing lab coats entering the research labs
ALT The Queen looking down a microscope in the advanced light microscopy lab
ALT The Queen chatting with members of the diabetes research team
Natalie Edner retweeted
It was an honour to welcome Her Majesty The Queen to the UCL Institute of Immunity & Transplantation. Such a fantastic JDRF event discussing our #type1diabetes research and the #ConnectImmuneResearch partnership. @iit_ucl @RoyalFreeChty
1/2 👑We’re delighted to have welcomed Her Majesty The Queen to the UCL Institute of Immunity and Transplantation today where we’re funding research into multiple auto immune conditions.
@ucl @iit_ucl @RoyalFreeChty @RoyalFamily
