@ParkerLab_MPIPZ

We’re interested in understanding how plants activate and fine-tune their innate immune responses towards invasive (host-adapted) biotrophic pathogens.

 Cologne, Germany
mpipz.mpg.de/parker
Joined July 2015
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53Media
nature.com/articles/s41586-0… "Balanced plant helper NLR activation by a modified host protein complex" Fine tuning of immune responses

Balanced plant helper NLR activation by a modified host protein complex

Nature - In Arabidopsis, mechanisms for NRG1A activation by recognition of a modified host EDS1–SAG101 complex, and NRG1A inhibition by NRG1C through sequestration of activated...

nature.com
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Bioinformatics and functional analysis of EDS1 genes in Brassica napus... sciencedirect.com/science/ar…
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"Bioengineering a plant NLR immune receptor with a robust binding interface toward a conserved fungal pathogen effector" Great work from @ZdrzalekR at @mjbanfield lab #BlastOFF pnas.org/doi/10.1073/pnas.24…

Bioengineering a plant NLR immune receptor with a robust binding interface toward a conserved...

Bioengineering of plant immune receptors has emerged as a key strategy for generating novel disease resistance traits to counteract the expanding t...

pnas.org
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Conifers Concentrate Large Numbers of NLR Immune Receptor Genes on One Chromosome academic.oup.com/gbe/article…

Conifers Concentrate Large Numbers of NLR Immune Receptor Genes on One Chromosome

Abstract. Nucleotide-binding domain and leucine-rich repeat (NLR) immune receptor genes form a major line of defense in plants, acting in both pathogen rec

academic.oup.com
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The Plant Cell in a Nutshell: A phosphorylation module regulates soybean basal immunity plantae.org/a-phosphorylatio… @ASPB #PlantSci

A phosphorylation module regulates soybean basal immunity | Plantae

Zhang et al. identify a signaling cascade mediating soybean cyst nematode resistance. https://doi.org/10.1093/plcell/koae008 By Lei Zhang and Xiaoli Guo, National Key Laboratory of Agricultural…

plantae.org
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📢NEW #Preprint ‼️ Magnum opus of @MarionClavel4 w/ excellent help from many amazing people. Keywords: #autophagy #viruses #modified_self_recognition #immune_signaling. Please let us know what you think.🧵 summarising our key findings
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IN BRIEF: From algae to apples: The structural and functional conservation of NLRs (Michael Busche, Bradley Laflamme) buff.ly/3QmUHL7 @JohnInnesCentre @Khongsam_Chia @Phil_Carella @ASPB #PlantSci
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Congratulations Jane Parker of @mpipz_cologne, newly inducted NAS international member! #NAS161 #NASmember #genetics #plantbiology
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Parker Lab retweeted
Cell@CellCellPress25 Apr 2024
As part of the #50YearsofCell, our focus issue on Immunology is out! ⁠ ⁠ This issue brings Cell’s 50th anniversary celebrations straight to your lymph nodes with reviews, perspectives and more thought-provoking articles on topics ranging from innate immunity to plant immune systems, and immunological strategies for bacterial detection. ⁠ ⁠ In addition, it features research articles on the mapping of the microbiome across metastatic cancers, a time-series reconstruction of human centriole assembly and how an inhibitory ligand acts directly on CD3e to boost tumor-specific T cell cytotoxicity and limit tumor growth.⁠ ⁠ ⁠To read more click here 👉 cell.com/cell/current
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The N-terminal domains of NLR immune receptors exhibit structural and functional similarities across divergent plant lineages (Khong-Sam Chia, Jiorgos Kourelis, Albin Teulet, et. al.) buff.ly/3JhE67n @JohnInnesCentre @Khongsam_Chia @Phil_Carella @ASPB #PlantSci
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📣New publication out by Schulze-Lefert and Chai @mpipz_cologne @Westlake_Uni on how phase separation plays a role in the immune system of #plants. Now published in @Nature Congratulations! 🥳👏👏 Learn more 👉bit.ly/3PHLH31 #Immunology nature.com/articles/s41586-0…

Researchers solve mystery of how minimalist plant immune molecules become activated 

The study provides new insights into how immune proteins are activated and thereby protect plants from infections.

mpipz.mpg.de
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Substrate-induced condensation activates plant TIR domain proteins @Nature nature.com/articles/s41586-0…
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A plant immunity protein interacts with a fungal cell wall–degrading enzyme to create immunogenic compounds, according to a new study in Science. Learn more ⬇️ 📄: scim.ag/5Xa #SciencePerspective: scim.ag/5X9
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Parker Lab retweeted
Bruno Ngou@BrunoNgou1 Feb 2024
Our story on the origin and evolution of plant PRRs is out @NatureComms ! nature.com/articles/s41467-0… A short & illustrated summary of this story:
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Parker Lab retweeted
Isabel Saur@IzzySaur21 Jul 2023
First major paper accepted from the saur lab: tinyurl.com/mv3zjtxr We demonstrate atypical AVR effector function: inhibition of the barley MLA13 NLR by the AVRa13-V2 variant. Thx to the editor and reviewers for their suggestions. With @MerleBS4 & @Emma_Crean_
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The @ISMPMI meeting is coming to an end: Plenary Session 8 (chaired by @ParkerLab_MPIPZ) is kicking off with @kseniakrasileva, talking about biodiversity of plant innate immune receptors and pathogen effectors #2023ISMPMI
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Great experience on the first day of #2023ISMPMI ! I will present a poster related to glutamate receptor-like channels(GLRs) promoted host cell death in ETI on Monday. Looking forward to seeing you tomorrow at P-166 in Immune Receptors II session during 12:30-13:15.
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Please visit her talk and poster. #2023ismpmi #mlkl #concurrentsession1
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I’m very happy to present my poster at #2023ISMPMI on Monday in the Plant Immunity Mechanisms session II (12:30 to 13:15). Come by P-286 if you want to chat about EDS1-PAD4 immune signaling and are interested in what a cysteine protease potentially has to do with it 🌱
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