PhD student @UniBasel working on metapopulation genomics
Basel, Switzerland
Joined November 2021
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Also included: High-quality genome assemblies, an overview of present/absent protein domains and repeat activity across microsporidia.
New prepint on microsporidia genome architecture. We (@peterdfields) find covariance in GC content, chromosomal sequence arrangement, and epigenetic modification doi.org/10.1101/2025.01.20.6…
Pascal Angst retweeted
Variation in genome architecture and epigenetic modification across the microsporidia phylogeny biorxiv.org/cgi/content/shor… #biorxiv_evobio
Pascal Angst retweeted
Genome-wide allele frequency changes reveal that dynamic metapopulations evolve differently biorxiv.org/cgi/content/shor… #biorxiv_evobio
We contrast these findings with a large, stable population of the same species, which allows us to identify and explicate the ways in which metapopulation dynamics affect SFS in important and quantifiable ways. (4/4)
We link the shifts to colonization, immigration, and other metapopulation-specific processes. Thus, we demonstrate a novel use of this summary as an indicator of rapid evolution in response to ecology. (3/4)
In this study, we follow the distribution of individual subpopulation’s site frequency spectrum (SFS) for five years. This allowed us to identify real-time shifts in the SFS. The SFS is a genomic summary that is often assumed to be quite temporally stable. (2/4)
Here the study I presented @Biology24Zurich. It characterizes whole-genome allele frequency changes in dynamic metapopulations giving insights into their evolution. @peterdfields and I are looking forward to any sort of feedback doi.org/10.1101/2024.01.18.5… (1/4)
New year, new study organism! Finally some genomes of porcelain crabs: doi.org/10.1093/g3journal/jk… Many thanks to Jonathon Stillman for involving me in the project. #G3Journal
@GeneticsGSA
Thanks for organizing the Microsporidia Fest @BhabhaEkiertLab and offering me the opportunity to give a talk. Is there a tag for #MicrosporidiaFest, or is it a secret organization that I accidentally revealed? See the slides of my short presentation at: github.com/pascalangst/pasca…
It's done. Even though not 100% complete, we finally feel confident to publish this genome doi.org/10.1093/g3journal/jk…. Bourbon, right @peterdfields? 🥳
Thanks, everyone, for the discussions at #SMBE2023. For those who missed the sweaty poster session, here is a link to our SFS approach for the study of metapopulations doi.org/10.6084/m9.figshare.… – at Ferrara, Emilia Romagna
Pascal Angst retweeted
Uncovering the Genomic Basis of Infection Through Co-genomic Sequencing of Hosts and Parasites buff.ly/3NN1Bad #science #evolution #biology #genome
I spent two weeks at @Tvarminne doing field work and finishing the genome report for Hamiltosporidium tvaerminnensis – named after this place. It was a truly inspiring trip. Thank you @peterdfields, Dieter Ebert, Jean-François, and Jürgen doi.org/10.1101/2023.06.02.5…
Publication news: Our article about a microsporidium with a genome size of about 2 Mbp. (Eukaryote!) is out in #G3Journal @GeneticsGSA including the first microsporidian mutation rate estimate. When do we celebrate @peterdfields and Dieter Ebert? 🥳 doi.org/10.1093/g3journal/jk…
Two years of my PhD are history and they went by so fast 😳 We managed to publish a first bit in @MolBioEvol: doi.org/10.1093/molbev/msac2… Thank you Camille Ameline, Christoph Haag, @FridaBen_Ami, Dieter Ebert, and @peterdfields!
