@PatFernRod

Postdoctoral Research Fellow | @TheColonnaLab | Washington University in St. Louis

 St Louis, MO
Joined May 2021
  • Tweets100
  • Following268
  • Followers179
Patrick Rodrigues retweeted
Jonathan Kagan@jkagan1Sep 2
Change the textbooks. Trans-splicing as a means to diversify the proteome. Many congrats to Ruaidhri Jackson and Olivia Venezia on this remarkable discovery. nature.com/articles/s41586-0…

Functional chimeric mRNAs encode proteins in mammalian immunity

Nature - Inflammation induces interchromosomal DNA interactions that bring parent genes into close proximity, facilitating the formation of chimeric mRNAs that encode physiologically relevant,...

nature.com
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Patrick Rodrigues retweeted
Feiya Ou@FeiyaOu1Aug 25
Glad to share that my preprint "ID2 secures cDC1 specification by antagonizing E proteins at a pleiotropic Zeb2 enhancer" is out today in @NatImmunol This represents another major piece of my PhD work. nature.com/articles/s41590-0… Preprint thread: xitter.cf/FeiyaOu1/status/196363…

ID2 secures cDC1 specification by antagonizing E proteins at a pleiotropic Zeb2 enhancer

Nature Immunology - Murphy and colleagues report that the transcriptional regulator ID2 promotes cDC1 fate specification by antagonizing E protein activity at E-boxes within the Zeb2 enhancer and...

nature.com
Feiya Ou@FeiyaOu14 Sep 2025
🧵1/8 Happy to share my new preprint “ID2 secures cDC1 specification by antagonizing E proteins at a pleiotropic Zeb2 enhancer.” I resolved why ID2 is essential for cDC1 lineage specification and uncovered a new paradigm of enhancers. Read here: researchsquare.com/article/r…

ID2 secures cDC1 specification by antagonizing E proteins at a pleiotropic Zeb2 enhancer

The transcriptional regulator ID2 is required for type 1 classical dendritic cell (cDC1) specification, yet the mechanism has remained obscure. We previously identified the Zeb2 -165-kb enhancer as...

researchsquare.com
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Patrick Rodrigues retweeted
The Colonna Lab@TheColonnaLabAug 15
New paper from the Colonna lab! cMAF is a key regulator of BAM identity and drives communication with brain arteries via IGF1. We show that this cMAF-dependent program in BAMs supports cerebrovascular function in mice and is protective against AD. cell.com/cell/fulltext/S0092…

Brain perivascular macrophages regulate endothelial cell function via a cMAF-dependent transcript...

This study identifies cMAF as a key transcription factor that orchestrates the molecular crosstalk between brain perivascular macrophages and arteries, thereby sustaining cerebrovascular function in...

cell.com
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Patrick Rodrigues retweeted
Julia Belk
@juliabelkAug 14
The transcription factor MAF is known from human genetics to be important in Alzheimer’s disease, but its precise function within the brain has been unclear. Our latest, out today in @CellCellPress, dissects the role of MAF in brain macrophages. 1/ cell.com/cell/fulltext/S0092…

Brain perivascular macrophages regulate endothelial cell function via a cMAF-dependent transcript...

This study identifies cMAF as a key transcription factor that orchestrates the molecular crosstalk between brain perivascular macrophages and arteries, thereby sustaining cerebrovascular function in...

cell.com
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Patrick Rodrigues retweeted
Immunity@ImmunityCPJul 28
Online now: TCR origin and specificity to environmental or self-antigens on distinct antigen-presenting cells determine peripheral Treg cell differentiation dlvr.it/TTlSNB

TCR origin and specificity to environmental or self-antigens on distinct antigen-presenting cells...

Using CRISPR-based TCR editing, Chi et al. systematically compare gut TCRs recognizing dietary, microbial, and self-antigens to define the principles that govern peripheral Treg cell differentiation....

cell.com
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Patrick Rodrigues retweeted
Waggoner Lab@LabWaggonerJul 21
Dysbiosis-induced expansion of AXL-positive inflammatory type 3 dendritic cells triggers preclinical autoimmunity @NatImmunol @GrozdanCvijetic @NIH nature.com/articles/s41590-0… @bioroxane
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Patrick Rodrigues retweeted
Sophie Janssens Lab@JanssensLabJul 19
Almost 15 years after our initial observation that IRE1 is specifically active in cDC1s, we finally start understanding why… Check out the new study from @victor.bosteels, published in @natcomms.nature.com Paper in press @ rdcu.be/fur4Q
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Patrick Rodrigues retweeted
Miriam Merad, MD, PhD@MiriamMeradJul 16
Excited to share our new study @ScienceMagazine by the fantastic Raphael Mattiuz and @jboumelha @SinaiImmunol showing how DC build and sustain tertiary lymphoid structures in cancer. A major step toward enhancing anti-tumor immunity (1/2) science.org/doi/10.1126/scie…
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Patrick Rodrigues retweeted
Ai Ing Lim@AiingLimMay 13
LIMmunity 2nd brew !! Motherhood comes with superpower: pathogen protection! nature.com/articles/s41586-0… We often think moms are immunologically vulnerable to tolerate the baby. But I always wondered: why would evolution make such a critical period of life so dangerous?

Eosinophils drive intestinal remodelling and innate defence in reproduction

Nature - From pregnancy until lactation, eosinophils accumulate in the small intestine where they regulate goblet cell fate and enhance innate defences against enteric pathogens.

nature.com
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Fachi, Trsan, Colonna et al. identify LINGO4 as a key regulator of ILC3s, coordinating mitochondrial fitness & IL-22 production. LINGO4 deficiency disrupts #ILC3 function & #microbiota composition, altering susceptibility to enteric infections hubs.la/Q04dLS_k0
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Patrick Rodrigues retweeted
The Colonna Lab@TheColonnaLabApr 29
Excited to share our latest work in J Exp Med! We identify LINGO4 as a key regulator of ILC3 fitness, IL-22 production and microbiota homeostasis, with major impact on host defense against enteric infection. Check it out! doi.org/10.1084/jem.20252632

LINGO4 coordinates ILC3-intrinsic IL-22 production and microbiota-mediated ILC3 homeostasis

Fachi et al. identify LINGO4 as a key regulator of ILC3s, coordinating mitochondrial fitness and IL-22 production. LINGO4 deficiency disrupts ILC3 function

rupress.org
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Patrick Rodrigues retweeted
Siling Du@DuSilingMar 11
🧵Excited to share my thesis work out today in @NeuroCellPress from @kipnislab and @TheColonnaLab: "Brain-Engrafted Monocyte-derived Macrophages from Blood and Skull-Bone Marrow Exhibit Distinct Properties." 🧠🦴 sciencedirect.com/science/ar…
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Patrick Rodrigues retweeted
The Colonna Lab@TheColonnaLabMar 6
Our study is out in @ScienceMagazine! It shows that CAR-expressing astrocytes (CAR-A) can recognize and clear amyloid aggregates, reducing pathology and restoring microglial homeostasis in AD models. Led by Yun Chen, Alex Liu and @khainotkaiorky! doi.org/10.1126/science.ads3…

Targeting amyloid-β pathology by chimeric antigen receptor astrocyte (CAR-A) therapy

Alzheimer’s disease (AD) is the leading cause of dementia and is characterized by progressive amyloid accumulation followed by tau-mediated neurodegeneration. Despite advances in anti-amyloid...

science.org
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Patrick Rodrigues retweeted
Science Immunology@SciImmunologyMar 2
Platelet-derived growth factor D (#PDGFD) binds to PDGFRβ in #ILC3s in mice and NKp44 in human ILC3s, promoting divergent innate immune responses following intestinal infections. @TheColonnaLab Learn more in Science #Immunology: scim.ag/4aXJmL1
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Patrick Rodrigues retweeted
The Colonna Lab@TheColonnaLabFeb 28
Excited to share our new work in @SciImmunology, led by @zefachi! Mesenchymal cells produce PDGF-D during colitis, driving species-specific ILC3 programs: via PDGFRβ in mice (IL-22, repair) and NKp44 in humans (type I response, pathogen clearance). science.org/eprint/EFDJ3BJRF…

Divergent ILC3 responses to PDGF-D control mucosal immunity

PDGF-D engages PDGFRβ in mice and NKp44 in humans to drive ILC3 responses.

science.org
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Patrick Rodrigues retweeted
Waggoner Lab@LabWaggonerFeb 27
PDGF-D engages PDGFRβ in mice and NKp44 in humans to drive ILC3 responses @SciImmunology science.org/doi/10.1126/scii… @TheColonnaLab @zefachi
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Patrick Rodrigues retweeted
Waggoner Lab@LabWaggonerJan 29
A distinct lymphoid progenitor generates RORγt+ DCs via a REV-ERB–controlled RORγt enhancer and PRDM16–PU.1-transcriptional programs @SciImmunology @TheColonnaLab @WashU science.org/doi/10.1126/scii…
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Patrick Rodrigues retweeted
Science Immunology@SciImmunologyJan 27
A new Science #Immunology study pinpoints the developmental origin of a distinct group of #DendriticCells that express the transcription factor #RORγt and highlights molecular players that regulate this process. scim.ag/45vKMue
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Patrick Rodrigues retweeted
The Colonna Lab@TheColonnaLabJan 27
Excited to share that our work by @PatFernRod & @TongWu99 is published: RORγt⁺ DCs are a distinct lymphoid-derived lineage whose development is controlled by REV-ERBα/β, PRDM16 and PU.1, enabling pTreg induction and protection from Th2-skewed responses. rb.gy/lyvce8

RORγt+ dendritic cells are a distinct lymphoid-derived lineage

A distinct lymphoid progenitor generates RORγt+ DCs via a REV-ERB–controlled RORγt enhancer and PRDM16-PU.1 transcriptional programs.

science.org
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Patrick Rodrigues retweeted
Salva Iborra@salva_iborra25 Nov 2025
Excited to share our new paper in @JExpMed ! 🎉 We reveal a key mechanism showing how tissue-resident memory CD8⁺ T cells (Trm) amplify antiviral protection during reinfection. 🧵👇1/6 xitter.cf/JExpMed/status/1993389…
Journal of Experimental Medicine@JExpMed25 Nov 2025
.@ElenaHerndezGa1, @salva_iborra and colleagues @Unicomplutense show that #plasmacytoid dendritic cells amplify the response of tissue-resident memory CD8⁺ T cells (#Trm) during viral reinfection, enhancing local #antiviral protection. hubs.la/Q03VRyd40 #MucosalImmunology
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