Re: My skepticism regarding GLP-1 drugs for obesity Yes, these drugs are effective for some people. However, don’t get carried away yet, especially for calls for the widespread use of these drugs. I am old enough to have seen the rise and fall of: The jejuno-ileal bypass Very low calorie diets Vertical banded gastroplasty Phen-Phen Gastric bands Orlistat Each of these was greeting with substantial enthusiasm and, given enough time, failed when long-term problems became apparent. Semaglutide roared onto the scene as the cure for obesity. With time, its side effects and limitations became apparent. It took little time before a new class of drugs with multi-receptor properties were advocated as the perfect solution for obesity. The history of weight loss interventions suggests that these new drugs will also have problems and be abandoned when the next, greatest drug is promoted by Pharma. I’d like to be wrong on this, but I have been around long enough to experience this cycle repeatedly.