Pelletier Lab retweeted
Pleased to share our latest study using super resolution to show that a pathogenic Tau mutation drives autophagy-lysosome dysfunction that limits Tau degradation in a model of frontotemporal dementia by the amazing Dr Mirfakhar 🔬🧫 nature.com/articles/s41467-0…
Pelletier Lab retweeted
Congrats to Tiger Jian on leading this innovative study advancing vascularized human organoids for therapeutic testing. Great collaborative work from the Pelletier, Wrana & Attisano labs.
@JeffWrana @UofT @SinaiHealth
#Organoids #BiomedicalResearch
Pelletier Lab retweeted
Chromosomes stuck behind the spindle are ticking time bombs for aneuploidy. We uncovered a mechanical rescue mechanism where microtubule pivoting repositions these high-risk chromosomes! Out last week in @NatureComms, here's a thread 🧵
shorturl.at/OD89x
Check this one out!
🚨 We are hiring! Personally, I think this is a fantastic job, good salary, and fun work place with exceptional colleagues @humantechnopole.
⚠️ Warning, I’m quite biased… but still right! 😜
Join us! Apply!!! 🎉
careers.humantechnopole.it/j…
Pelletier Lab retweeted
Congratulations to Dr. Keiran Campbell, investigator at LTRI, on receiving the Canadian Society of Molecular Bioscience’s New Investigator Award (@CSMB_SCBM), recognizing his achievements and leadership in computational cancer biology 👏
#SinaiHealth #LTRI #CancerResearch
Pelletier Lab retweeted
This is fascinating! By introducing physiological vascular flow in vitro, you're opening new avenues for understanding how hemodynamic forces shape vascular architecture. Have you observed any significant differences in the vascularization of organoids compared to native tissues? And how might these insights help in developing treatments for Hereditary Hemorrhagic Telangiectasia? For more on such exciting biomedical topics, check out Sci-Quest, a one-stop platform to generate comprehensive reviews: sciqst.com #VascularBiology #Medicine #BiomedicalResearch
Pelletier Lab retweeted
Pelletier Lab retweeted
Perfusing lab-grown mini-organs revolutionizes the current model systems.
Grateful to be part of this incredible team at @SinaiHealth and @UofT. Credits: @tigerhzjian @CallumJStirton @PelletierLab
Check out our preprint for more exciting science:
lnkd.in/eXwi7NtY
Pelletier Lab retweeted
First time I’ve seen real scientific figures that look like those absurdly inaccurate magical science clips shown in movies or tv series. Kudos to the authors for making them so attractive! -and for their paper, of course-
Pelletier Lab retweeted
Incredible stuff from Tiger in Pelletier lab
Pelletier Lab retweeted
Cool! You could likely use in silico models made by Peter Balogh and Prosenjit Bagchi to predict capillary dynamics and RBC partitioning, then use your vascularized organoids to test their predictions.
@PBNeuroVascLab
Pelletier Lab retweeted
(1/6): How can we better test therapeutics without using animals or risking lives? Lab-grown human mini-organs, called “organoids”, provide an answer! Despite their progress, organoids and related methods lack realistic flow through blood vessels, the “plumbing” of our bodies.
Pelletier Lab retweeted
(1/7): New preprint from the lab! We generate physiological vascular flow in vitro to vascularize organoids, interrogate the effects of hemodynamic forces on vascular architecture, and model the disease Hereditary Hemorrhagic Telangiectasia.
(1/7): New preprint from the lab! We generate physiological vascular flow in vitro to vascularize organoids, interrogate the effects of hemodynamic forces on vascular architecture, and model the disease Hereditary Hemorrhagic Telangiectasia.
(6/7): This work was led by @tigerhzjian and powered by an amazing team @UofT & @SinaiHealth. Credits to @Sivitilli91, @EllaYaxinGuo, @callum_stirton and @JessicaGosio, and the labs of Dr. Laurence Pelletier, Dr. Jeff Wrana (@jeffwranalab), and Dr. Liliana Attisano.
(7/7): Check out our preprint, @tigerhzjian for a related post, and stay tuned for more!
biorxiv.org/content/10.64898…