Pelletier Lab (@PelletierLab) profile picture

Pelletier Lab

@PelletierLab
pelletierlab.org/
Joined July 2011
  • Tweets82
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  • Followers222
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Photo by Pelletier Lab (@PelletierLab)Photo by Pelletier Lab (@PelletierLab)Photo by Pelletier Lab (@PelletierLab)Photo by Pelletier Lab (@PelletierLab)
Pelletier Lab retweeted
Celeste Karch (@karchlab) profile picture
Celeste Karch@karchlabApr 2
Pleased to share our latest study using super resolution to show that a pathogenic Tau mutation drives autophagy-lysosome dysfunction that limits Tau degradation in a model of frontotemporal dementia by the amazing Dr Mirfakhar 🔬🧫 nature.com/articles/s41467-0…
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Congrats to Tiger Jian on leading this innovative study advancing vascularized human organoids for therapeutic testing. Great collaborative work from the Pelletier, Wrana & Attisano labs. @JeffWrana @UofT @SinaiHealth #Organoids #BiomedicalResearch
Tiger Jian (@tigerhzjian) profile pictureTiger Jian@tigerhzjianMar 25
(1/6): How can we better test therapeutics without using animals or risking lives? Lab-grown human mini-organs, called “organoids”, provide an answer! Despite their progress, organoids and related methods lack realistic flow through blood vessels, the “plumbing” of our bodies.
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Pelletier Lab retweeted
Iva Tolić (@Toliclab) profile picture
Iva Tolić@ToliclabMar 27
Chromosomes stuck behind the spindle are ticking time bombs for aneuploidy. We uncovered a mechanical rescue mechanism where microtubule pivoting repositions these high-risk chromosomes! Out last week in @NatureComms, here's a thread 🧵 shorturl.at/OD89x
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Pelletier Lab retweeted
kipling_r (@kipling___r) profile picture
kipling_r@kipling___rMar 27
Replying to @tigerhzjian
Consider collab. w. Arlotta Lab, (Harv.) they have had multi-cell organoids (neuro) for some time + are prob. interested in implementing vascularization. Best of luck!
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Pelletier Lab retweeted
Sinai Health (@SinaiHealth) profile picture
Sinai Health@SinaiHealthMar 24
Congratulations to Dr. Keiran Campbell, investigator at LTRI, on receiving the Canadian Society of Molecular Bioscience’s New Investigator Award (@CSMB_SCBM), recognizing his achievements and leadership in computational cancer biology 👏 #SinaiHealth #LTRI #CancerResearch
Image from Sinai Health (@SinaiHealth)
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Pelletier Lab retweeted
sciqst (@sciqst) profile picture
sciqst
@sciqstMar 26
Replying to @PelletierLab
This is fascinating! By introducing physiological vascular flow in vitro, you're opening new avenues for understanding how hemodynamic forces shape vascular architecture. Have you observed any significant differences in the vascularization of organoids compared to native tissues? And how might these insights help in developing treatments for Hereditary Hemorrhagic Telangiectasia? For more on such exciting biomedical topics, check out Sci-Quest, a one-stop platform to generate comprehensive reviews: sciqst.com #VascularBiology #Medicine #BiomedicalResearch
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Pelletier Lab retweeted
Upasana DasAdhikari (@UpasanaDA) profile picture
Upasana DasAdhikari@UpasanaDAMar 26
biorxiv.org/content/10.64898…
Tiger Jian (@tigerhzjian) profile pictureTiger Jian@tigerhzjianMar 25
(1/6): How can we better test therapeutics without using animals or risking lives? Lab-grown human mini-organs, called “organoids”, provide an answer! Despite their progress, organoids and related methods lack realistic flow through blood vessels, the “plumbing” of our bodies.
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Pelletier Lab retweeted
Ella Guo (@EllaYaxinGuo) profile picture
Ella Guo@EllaYaxinGuoMar 25
Perfusing lab-grown mini-organs revolutionizes the current model systems. Grateful to be part of this incredible team at @SinaiHealth and @UofT. Credits: @tigerhzjian @CallumJStirton @PelletierLab Check out our preprint for more exciting science: lnkd.in/eXwi7NtY
Tiger Jian (@tigerhzjian) profile pictureTiger Jian@tigerhzjianMar 25
(1/6): How can we better test therapeutics without using animals or risking lives? Lab-grown human mini-organs, called “organoids”, provide an answer! Despite their progress, organoids and related methods lack realistic flow through blood vessels, the “plumbing” of our bodies.
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Pelletier Lab retweeted
Felipe Del Valle (@coffee_lipe) profile picture
Felipe Del Valle@coffee_lipeMar 26
First time I’ve seen real scientific figures that look like those absurdly inaccurate magical science clips shown in movies or tv series. Kudos to the authors for making them so attractive! -and for their paper, of course-
Tiger Jian (@tigerhzjian) profile pictureTiger Jian@tigerhzjianMar 25
(1/6): How can we better test therapeutics without using animals or risking lives? Lab-grown human mini-organs, called “organoids”, provide an answer! Despite their progress, organoids and related methods lack realistic flow through blood vessels, the “plumbing” of our bodies.
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Pelletier Lab retweeted
durocherlab (@durocherlab) profile picture
durocherlab@durocherlabMar 26
Incredible stuff from Tiger in Pelletier lab
Tiger Jian (@tigerhzjian) profile pictureTiger Jian@tigerhzjianMar 25
(1/6): How can we better test therapeutics without using animals or risking lives? Lab-grown human mini-organs, called “organoids”, provide an answer! Despite their progress, organoids and related methods lack realistic flow through blood vessels, the “plumbing” of our bodies.
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Pelletier Lab retweeted
Lior Golgher (@LiorKir) profile picture
Lior Golgher@LiorKirMar 26
Replying to @tigerhzjian
Cool! You could likely use in silico models made by Peter Balogh and Prosenjit Bagchi to predict capillary dynamics and RBC partitioning, then use your vascularized organoids to test their predictions. @PBNeuroVascLab
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Pelletier Lab retweeted
Tiger Jian (@tigerhzjian) profile picture
Tiger Jian@tigerhzjianMar 25
(1/6): How can we better test therapeutics without using animals or risking lives? Lab-grown human mini-organs, called “organoids”, provide an answer! Despite their progress, organoids and related methods lack realistic flow through blood vessels, the “plumbing” of our bodies.
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Pelletier Lab retweeted
Pelletier Lab (@PelletierLab) profile picture
Pelletier Lab@PelletierLabMar 25
(1/7): New preprint from the lab! We generate physiological vascular flow in vitro to vascularize organoids, interrogate the effects of hemodynamic forces on vascular architecture, and model the disease Hereditary Hemorrhagic Telangiectasia.
Image from Pelletier Lab (@PelletierLab)
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Pelletier Lab retweeted
Amit Sharma (@Amit_Cellbio) profile picture
Amit Sharma@Amit_Cellbio14 Dec 2024
Explore our endo-taging paper. Nt only, it is gd fr fluorescent taging (wide array of photostable tag lik mStayGold)bt also fr endogenous proteomic stdies n endogenous protein degradation using degradation system @PelletierLab links addgene.org/Laurence_Pelleti… embopress.org/doi/full/10.10…
Image from Amit Sharma (@Amit_Cellbio)
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Pelletier Lab retweeted
Reuben Philip (@reuben_phi) profile picture
Reuben Philip@reuben_phi13 Dec 2024
Explore our tagging tools from the @Pelletierlab! They feature cassettes with mStayGold for bright and photostable endogenous fusions. Now available on @Addgene: addgene.org/Laurence_Pelleti…. Check out the paper in @embojournal: embopress.org/doi/full/10.10… #FluorescenceFriday
Image from Reuben Philip (@reuben_phi)
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The @Nikon Centre of Excellence was officially opened last month at LTRI/@SinaiHealth with a mini-symposia hosted by NBCC's @laurpelletier. Access these advanced systems through the NBCC. Find out more at bit.ly/3VpZqyF.
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Sinai Health (@SinaiHealth) profile picture
Sinai Health@SinaiHealth22 Mar 2024
Thanks to a $10M investment, Sinai Health’s Drs. Jeff Wrana & @laurpelletier are developing lab-grown organoids to unlock secrets of the brain & beyond. This could revolutionize disease research & drug discovery. @InnovationCA @NikonUSA bit.ly/43vLRAb
Image from Sinai Health (@SinaiHealth)
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Pelletier Lab retweeted
Reuben Philip (@reuben_phi) profile picture
Reuben Philip@reuben_phi10 Nov 2023
Previous submissions to @NikonSmallWorld. Dividing with too many centrosomes! #FluorescenceFriday #Centrosome
Image from Reuben Philip (@reuben_phi)
Image from Reuben Philip (@reuben_phi)
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qTAG: An adaptable CRISPR-based endogenous tagging protocol using optimized repair cassettes biorxiv.org/content/10.1101/…
Image from Joachim Goedhart (@joachimgoedhart)
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qTAG: An adaptable CRISPR-based endogenous tagging protocol using optimized repair cassettes biorxiv.org/cgi/content/shor… #biorxiv_molbio
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