14 simplified natural product syntheses reported today in @ChemRxiv : bit.ly/42GpTJM. These syntheses are enabled by a next generation doubly decarboxylative cross coupling (dDCC) that tolerates alpha-heteroatom substituents. In addition to the critical Ag-additive that turns on reactivity, the ligands play a key role in stereo controlled couplings. Imagine a world where natural products like polypropionates can be made without recourse to aldol or epoxide chemistry but instead by just putting ubiquitous acid building blocks together like LEGOs. Retrosynthetic analysis is often taught using the concept of "polar bond analysis" which has inadvertently led to an over-reliance on protecting groups, functional group manipulations, and redox-fluctuations. The advantages of radical retrosynthesis (pubs.acs.org/doi/10.1021/acs…), which is polarity agnostic, is on vivid display in this disclosure. Thanks to our amazing collaborators at BMS (medchem and process), Pfizer, Biogen, and LEO Pharma.