@RuijterLab

Dedicated to the development of creative methods for the synthesis of complex molecules

 Amsterdam, The Netherlands
Joined March 2021
  • Tweets183
  • Following163
  • Followers634
5Media
Woke up at 5:45 this morning😴, but it was totally worth it!😊 Had a blast sharing some sugar-sweet chemistry at the ⁦@HRSMC1⁩ symposium and loved all the insightful talks!🍬🍫 Great to see this community together!🎉
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Now as early view @angew_chem: Structure-Based Design of Bicyclic Helical Peptides That Target the Oncogene β-Catenin doi.org/10.1002/anie.2024117… Big congrats to first author @YesteAlejandro & thanks to our great collaborators @Al_rebreG @maric_hans @SchulteClemens #peptidomimetics
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Out now @angew_chem: Structure-Based Design of Bicyclic Helical Peptides That Target the Oncogene β-Catenin doi.org/10.1002/anie.2024117… Big congratulations to first author @YesteAlejandro and thanks to the great collaboration partners @Al_rebreG @maric_hans @SchulteClemens
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Replying to @PascalVermeeren
@PascalVermeeren wins KNCV-CTC Thesis Award🏆! Well done Pascal! 🎉 @KNCVchemie @VU_TheoCheM @VU_Science.
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Are you coming to the 2024 Dutch Peptide Symposium, May 31 at VU Amsterdam O2 auditorium? We have some exciting invited speakers confirmed, and now we need you! Registration is open until 20 May, abstracts until 1 May, all on dutchpeptidesymposium.com/
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Now online: Transcription factor-targeting stapled peptides @ChemBioChem We've captured 2 peptide confirmations with crystal structures & used MD simulations to understand the dynamics doi.org/10.1002/cbic.2024000… Congrats @Canan_Durukann @ioana_ilie_UvA @jocelyne_vreede @VU_Science
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Very proud of this work! 🔥 In 2021, our work on understanding H2 activation by metallylenes appeared in @ChemicalScience (doi.org/10.1039/D0SC05987K). Now we close the cycle and report how these metallylenes can potentially catalyze hydrogenation reactions in @EurJOC!⬇️
Eveline Tiekink@EvelineTiekink5 Mar 2024
Happy to see our work online! ✨ @SiebeLeDe @PascalVermeeren @TrevorAHamlin
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What a team effort it was, and the end result just blew our minds. If you want to know the story behind #RoboChem, check our blog article: noelresearchgroup.com/2024/0… I promise you there are some funny passages, drama and a happy ending with its publication today in @ScienceMagazine

The story behind the Science paper – How our team created RoboChem

When I embarked on my independent academic career, my mission was clear: to push the boundaries of synthetic organic chemistry through technological innovation. One of my most audacious dreams was to...

noelresearchgroup.com
Noel Research Group@NoelGroupUvA25 Jan 2024
We're absolutely thrilled that our robotic platform, #RoboChem, has been published in @ScienceMagazine! 🔗science.org/doi/10.1126/scie… #RoboChem can carry out your substrate scope and provide tailored reaction conditions for every single entry. 🤖 #FlowChemistry #photocatalysis
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Don't miss F. Matthias Bickelhaupt's et al.'s recent article - it's one of this week's #ChemSciCovers Nature and strength of group-14 A–A′ bonds 🔗 DOIhttps://doi.org/10.1039/D3SC06215E @Daniela_R_Silva @EvaBlokker @TrevorAHamlin @fmbickelhaupt @VU_TheoCheM
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We're absolutely thrilled that our robotic platform, #RoboChem, has been published in @ScienceMagazine! 🔗science.org/doi/10.1126/scie… #RoboChem can carry out your substrate scope and provide tailored reaction conditions for every single entry. 🤖 #FlowChemistry #photocatalysis
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One way or another!🍎↔️🍐 We explain in our new @JOC_OL how minimal changes in the donor impact the formation of different reactive intermediates and stereoselectivity!💥 Great Leiden-A'dam-Nijmegen team work!🤜🤛 @WA_Remmerswaal @HiddeElferink 🗞️▶️ doi.org/10.1021/acs.joc.3c02…
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Our #OpenAccess paper on the Blueshift in Trifurcated Hydrogen Bonds was featured on the cover of @ChemPhysChem! 🔥 Cover: doi.org/10.1002/cphc.2023009… Paper: doi.org/10.1002/cphc.2023009… @LucasAzdS Storm Shiri @CeliaFGuerra @fmbickelhaupt @VUamsterdam
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Drie VU-chemici zijn erin geslaagd om enzymen robuuster te maken. Dit opent de weg naar efficiëntere en duurzamere manieren om ze te gebruiken. Hierdoor is minder afval en efficiënter gebruik van grondstoffen mogelijk. vu.nl/nl/nieuws/2023/robuust…
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Online now @Chem_CP #INCYPRO stabilized protein complexes with • unprecedented chain topology • reduced aggregation tendency • exceptional longevity doi.org/10.1016/j.chempr.202… Big congrats to the @VU_Science & #incircular #startup team! Supported by @ERC_Research & @EUeic!
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We're excited to report the #INCYPRO engineering of protein complexes in CHEM! Congratulations to all team members @VU_Science and #incircular! @GeorgeHHutch @IvanaDrienovska @C3_POc @nicholas_pearce @anoukrijs Thanks @ERC_Research and @EUeic for their support! #OpenAccess
Chem@Chem_CP2 Nov 2023
Online now: Covalent bicyclization of protein complexes yields durable quaternary structures dlvr.it/SyJRc2

Covalent bicyclization of protein complexes yields durable quaternary structures

Modulating the stability of protein complexes is crucial for their use in biotechnological applications, such as biocatalysis, offering more sustainable alternatives to traditional chemical transfo...

cell.com
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Really great traditions in synthetic chemistry groups: Targeted Synthesis Challenges!!🎉 In other words: 🧱➡️🏠 with the right 🛠️ and 📄 Had again an awesome evening!❤️💪 ⁦@RuijterLab⁩ ⁦@brendan_horst⁩ ⁦@JaapHarteveld⁩ ⁦⁦@Sebstrahl⁩ @JanHvM⁩
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Very happy to see our environment-responsive RNA stabilizers in the current issue @angew_chem onlinelibrary.wiley.com/doi/… Thanks to the Brock lab for the great collaboration. Big congrats to everyone involved esp. first authors @mcloughliniall @MarAlbers @VU_Science #OpenAccess
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Thomas Hansen (@THansenChem) of @VUamsterdam presents an invited talk @ESOR2023 on exploring chemical glycosylation reactions. #ESOR2023
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Replying to @ESOR2023 @VUamsterdam
Really happy for the opportunity to show some of our sugar sweet work!!🧁🍬🍫 Very thrilled to be part of this awesome conference!!💯💪
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Interested in de novo peptide discovery, bicycles, and (somewhat orthogonal) cysteine reactivity? Check out our newest paper in @ChemicalScience together with @NitscheLab and @HaanXander pubs.rsc.org/en/content/arti…

Selective thiazoline peptide cyclisation compatible with mRNA display and efficient synthesis†

Peptide display technologies are a powerful method for discovery of new bioactive sequences, but linear sequences are often very unstable in a biological s

pubs.rsc.org
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