Julio Leon (@SCIJulioLeon) header
Julio Leon (@SCIJulioLeon) profile picture

Julio Leon

@SCIJulioLeon

Scientist: Neurobiology, Genomics, Bioinformatics, The Aging brain. Endless learner. UCSF & RIKEN_IMS|🇵🇪🇯🇵🇺🇸#DryandWetScientist #Samuraiscientist

 San Francisco, CA
linkedin.com/in/julio-leon-9764b6144
Joined January 2013
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Photo by Julio Leon (@SCIJulioLeon)Photo by Julio Leon (@SCIJulioLeon)Photo by Julio Leon (@SCIJulioLeon)Photo by Julio Leon (@SCIJulioLeon)Photo by Julio Leon (@SCIJulioLeon)Photo by Julio Leon (@SCIJulioLeon)Photo by Julio Leon (@SCIJulioLeon)Photo by Julio Leon (@SCIJulioLeon)Photo by Julio Leon (@SCIJulioLeon)Photo by Julio Leon (@SCIJulioLeon)
Our new paper from the @FrydmanLab published in @ScienceMagazine identifies 22 TRiC mutations in patients with brain disorders of unknown origin. We characterized these disease-linked mutations in 3 model species and found them to be dominant mutations. science.org/doi/10.1126/scie…
Brain malformations and seizures by impaired chaperonin function of TRiC

Brain malformations and seizures by impaired chaperonin function of TRiC

Malformations of the brain are common and vary in severity, from negligible to potentially fatal. Their causes have not been fully elucidated. Here, we report pathogenic variants in the core protei...

science.org
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I’ve been awarded an @alzassociation grant for my research that combines a multimodal approach to understanding the brain’s molecular pathological changes in aging and AD. Thanks to Carlo Condello, @JayShin, Nakabeppu, and Kubo Sensei for their support and mentorship. #ALZFunded
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5/We show that ILAs play a crucial role in the disrupted brain circuitry of schizophrenia and propose potential targets for novel therapies and morphological markers for histopathological diagnosis.
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6/Huge thanks to our incredible multidisciplinary team @SatoshiYoshina1, @JayShin, @chungchau_hon, @carninci , Kubo-sensei and others.
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7/ Find more in the link: biorxiv.org/content/10.1101/…. We look forward to engaging with the scientific community for feedback and discussions. #Spatialtranscriptomics #Bioinformatics #Brainaging #BioRxiv #Schizophrenia #Neuroscience #molecularneuroanatomy
Integrative Transcriptomics Reveals Layer 1 Astrocytes Altered in Schizophrenia

Integrative Transcriptomics Reveals Layer 1 Astrocytes Altered in Schizophrenia

Schizophrenia is one of the most prevalent psychiatric disorders with unclear pathophysiology despite a century-long history of intense research. Schizophrenia affects multiple networks across...

biorxiv.org
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3/ Further histological investigations showed that interlaminar astrocytes (ILA) in layer 1, which extend long processes into cortical layers, exhibited reduced cell density and abundance of processes in schizophrenia.
Image from Julio Leon (@SCIJulioLeon)
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4/We also found a negative relationship between ILA processes and GFAP+ cell density in the grey matter with "healthy" aging.
Image from Julio Leon (@SCIJulioLeon)
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1/ I am happy to share that our latest research paper is now available as a preprint on bioRxiv! 🧠🧬Integrative Transcriptomics Reveals Layer 1 Astrocytes Altered in Schizophrenia biorxiv.org/content/10.1101/…
Image from Julio Leon (@SCIJulioLeon)
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2/ We performed an integrative analysis of spatial and single-nucleus transcriptomics of the anterior cingulate cortex in schizophrenia patients, together with a thorough histological analysis. Our findings highlight significant alterations in glial cells, primarily astrocytes.
Image from Julio Leon (@SCIJulioLeon)
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Massive effort, honored to be part of it !
Piero Carninci (@carninci) profile picturePiero Carninci@carninci14 Nov 2023
Thrilled to share the efforts lead by @chungchau_hon at @RIKEN_IMS, at atlas of single-cell gene expression in 23 human tissues centered on 5' ends. Want to know how promoters and enhancers are identified in single cells? have a look at the manuscript: biorxiv.org/content/10.1101/…
A single-cell atlas of transcribed cis-regulatory elements in the human genome

A single-cell atlas of transcribed cis-regulatory elements in the human genome

Transcribed cis-regulatory elements (tCREs), such as promoters and enhancers, are fundamental to modulate gene expression and define cell identity. The detailed mapping of tCREs at single-cell...

biorxiv.org
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Immensely proud to share our four papers on #SingleCell dissection of #Alzheimers Disease coming out in @CellCellPress today, reporting 2.3M #scRNA profiles and 850k #scATAC profiles across 427 post-mortem human brain samples from AD and non-AD donors in a wonderful #interdisciplinary collaboration with @DrLiHueiTsai between @MIT @MIT_Picower @MIT_CSAIL @BroadInstitute @RushUniversity Paper 1: scRNA + vulnerability + resilience cell.com/cell/fulltext/S0092… Paper 2: scATAC + GWAS + Epigenome Erosion cell.com/cell/fulltext/S0092… Paper 3: Microglia States + reprogramming cell.com/cell/fulltext/S0092… Paper 4: DNA damage + gene fusions cell.com/cell/fulltext/S0092… MIT News: news.mit.edu/2023/decoding-c… Issue: cell.com/cell/current News & Views: cell.com/cell/fulltext/S0092…
Image from Manolis Kellis (@manoliskellis)
Image from Manolis Kellis (@manoliskellis)
Image from Manolis Kellis (@manoliskellis)
Image from Manolis Kellis (@manoliskellis)
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Single-nucleotide variant calling in single-cell sequencing data with Monopogen | Nature Biotechnology nature.com/articles/s41587-0…
Single-nucleotide variant calling in single-cell sequencing data with Monopogen

Single-nucleotide variant calling in single-cell sequencing data with Monopogen

Nature Biotechnology - Monopogen identifies single-nucleotide variants in single-cell sequencing data.

nature.com
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Scientific discussion and brainstorming session to push our ideas and improve our research. Good times with @SCIJulioLeon and @JARamilowski.
Image from Pauline Robbe (@PaulineRobbe)
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When you leave but never really leave ;)Schizophrenia research 🎯 Excited to contribute to understanding this complex disorder. #JikeiUniversity #spatialtranscriptomics #Japanbrainbank – at Koto-ku, Tokyo
Image from Julio Leon (@SCIJulioLeon)
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We are excited to release Seurat v5- with new methods for multimodal, spatially resolved, and massively scalable single-cell analysis. satijalab.org/seurat
Image from Rahul Satija (@satijalab)
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⭐️Cellular foundation for a new perspective of AD pathophysiology⭐️ 👉Cellular dynamics across aged human brains uncover a multicellular cascade leading to Alzheimer's disease biorxiv.org/content/10.1101/… Outstanding work from @naomi_habib and Philip L. De Jager labs!👏👏
Image from Lukas Valihrach (@LukasValihrach)
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Jackson Pollock or spatial profiling? A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain biorxiv.org/content/10.1101/… Preprint @AllenInstitute of whole mouse brain atlas, comprised of >11 million single cells profiled with scRNA seq & MERFISH 🤯
Image from Anirban Maitra (@Aiims1742)
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Delighted to share our paper in @stemcellreports on a novel 3D #iPSC-derived model of GRN- #FTD with a focus on astroglia toxicity. Fantastic collaboration with @UllianLab HuangLab @KampmannLab @synapticure @AlectorTx and others. #ALS #Organoids #TDP43 cell.com/stem-cell-reports/f…
Image from Martina de Majo (@MartinadeMajo)
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Meet my 94-year-old grand uncle in rural Peru, with some mobility problems but cognitively sharp, making jokes, and telling me about all the other relatives I need to visit, especially my other tio-Abuelo, who turned 100 last year. Tempted to take some blood samples #healthyaging
Image from Julio Leon (@SCIJulioLeon)
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Last experiment in Japan before going back to CA, #spatialtranscriptomics #NasuHakola disease!
Image from Julio Leon (@SCIJulioLeon)
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