@SamuelEButcher

Professor

 UW-Madison Biochemstry
Joined June 2014
  • Tweets17
  • Following132
  • Followers159
2Media
x-rays+magnets+RNA=cool structures
https://www.sciencedirect.com/science/article/pii/S0022283623004515?via%3Dihub

ALT https://www.sciencedirect.com/science/article/pii/S0022283623004515?via%3Dihub

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Congratulations to professor Judith Simcox (@JudithSimcox), who was named an @HHMINEWS Freeman Hrabowski Scholar. This new program supports 31 outstanding early career faculty committed to advancing diversity, equity and inclusion in science. Read more: biochem.wisc.edu/news/2023/n…
Judith Simcox.

ALT Judith Simcox.

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Sam Butcher retweeted
Ci Ji Lim@cijilim17 Apr 2023
Our latest publication reports the cryo-EM structures of the human Polα-Primase DNA elongation complexes - rdcu.be/c96yY A Lim lab X Tahirov lab collaboration led by @QixiangHe and Andrey. Thank you, @sarakosman & @NatureSMB, for working with us! Please RT to share! 1/4
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Now I kind of wish we'd called pUG RNA structure a "pUGoda" nature.com/articles/s41594-0…
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New from the Coyle Lab (and their first preprint!) ⬇️
Scott Coyle@CellRaiser_16 Nov 2022
Our first preprint is out! Led by Rohith Rajasekaran (@born2raisecell): “A programmable reaction-diffusion system for spatiotemporal cell signaling circuit design” A visually stunning toolkit to build cellular radios that probe or control cell biology. biorxiv.org/content/10.1101/…
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Excited to have this preprint out on work from @raghav_jain1 and @_JessDavidson in my group. Current LDL and HDL markers do not predict CVD in Black women. We used LCMS based lipidomics to identify arachodonic acid containing lipids as CVD predictors. medrxiv.org/content/10.1101/…

Identification of novel plasma lipid markers of cardiovascular disease risk in White and Black women

Rationale Cardiovascular disease (CVD) is the leading cause of mortality for women in the USA. Current clinical biomarkers are inadequate to determine CVD risk in women, especially Black women, who...

medrxiv.org
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Sam Butcher retweeted
Ci Ji Lim@cijilim17 Dec 2021
Structure of human CST-pol-α/primase bound to a telomeric overhang poised for initiation of telomere C-strand synthesis biorxiv.org/content/10.1101/…

Structure of human CST-pol-α/primase bound to a telomeric overhang poised for initiation of...

Telomere replication and regulation protect mammalian chromosome ends and promote genome stability. An essential step in telomere maintenance is the C-strand fill-in process, which is the de novo...

biorxiv.org
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An Atypical RNA Quadruplex Marks RNAs as Vectors for Gene Silencing biorxiv.org/content/10.1101/…

An Atypical RNA Quadruplex Marks RNAs as Vectors for Gene Silencing

The addition of poly(UG) (“pUG”) repeats to 3′ termini of mRNAs drives gene silencing and trans-generational epigenetic inheritance in the metazoan C. elegans .[1][1] pUG tails promote silencing by...

biorxiv.org
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First pre-print from the lab! #CryoEM structures of the #Caulobacter flagellum and associations with phage. Lovely work by Eric, Nicoleta, Juan, @Microscope_Dan @RebeccaDillard Conrad, @ZunlongKe and Ricardo. biorxiv.org/cgi/content/shor…
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And see companion paper with structural work by @SamuelEButcher and colleagues suggesting a gated mechanism for Lsm1-7 access to internal RNA binding sites. Both studies point to Pat1 as the gatekeeper!
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Congratulations to Joe Lobel for recent publication on how the mRNA decay factor Pat1 increases range of RNA substrates bound by the Lsm1-7 complex! Wishing Joe best of luck as he departs for work with @nickingolia. rnajournal.cshlp.org/content…
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Excited to have been selected and looking forward to getting to know these awesome scientists!!
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New paper from my lab: Molecular basis for the distinct cellular functions of the Lsm1-7 and Lsm2-8 complexes disq.us/t/3o34mlv
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Just setting up my Twitter. #myfirstTweet
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