Medical Genomics @uclcancer. Computational biology, epigenomics, transcriptomics, immune cells. Passion for science. Loves nature, traveling & photography.
Joined April 2010
- Tweets214
- Following102
- Followers147
- Likes401
Simone Ecker retweeted
#EWAS of smoking and #epigenetic #age acceleration among Costa Rican adults. Former smokers had consistent age acceleration and we replicated smoking related hits in Latine pop @drehkopf @SimoneEcker @r_fadadu @khnorthcote @lmcewen @GladishNicole @koborlab nature.com/articles/s41598-0…
Simone Ecker retweeted
⭐️ONLINE NOW @NatureCancer: "#Chemotherapy induces canalization of cell state in childhood B-cell precursor acute lymphoblastic #leukemia" by @TuratiVirginia @tariqenver &Co @UCL
Find it here!👇
go.nature.com/3hHKW8a
rdcu.be/cnUJc
#CancerTherapy #Chemoresistance
Simone Ecker retweeted
And what a journey! An extraordinarily thorough and painstaking investigation showing that treatment induced selection in B-ALL acts on #epigenetic, not genetic states.
Utmost respect for @TuratiVirginia.
#Cancer
Simone Ecker retweeted
Stoked to see our paper out today in @NatureCancer! Epigenetic cell state, not genetic variegation, is the principal substrate for bottleneck selection during induction chemotherapy in childhood BCP-ALL. Check it out here rdcu.be/cnL8X
@uclcancer
Simone Ecker retweeted
GOmeth and GOregion are gene set enrichment methods for DNA methylation data from @JovMaksimovic, @AliciaOshlack & @BelindaPhipson. It takes into account the fact that CpGs on chips are unevenly distributed between genes, &and some CpGs linked to >1 gene genomebiology.biomedcentral.…
Simone Ecker retweeted
So excited to announce our preprint “Epigenetic Patterns in a Complete Human Genome” where we generate the most complete human epigenome analysis to date and uncover novel insights into human centromere epigenetic regulation. A few highlights: biorxiv.org/content/10.1101/…
Simone Ecker retweeted
A big day for human genomics!
It's also very cool that this is released as a preprint.
The complete sequence of a human genome biorxiv.org/cgi/content/shor… #biorxiv_genomic
Simone Ecker retweeted
Our open letter about academic whistleblowers like
@MicrobiomDigest is mentioned in @guardian by @MelissaLDavey
You can find the letter here: osf.io/2awsv/
Scientists co-sign it here: docs.google.com/forms/d/e/1F……
The article is here theguardian.com/science/2021…
Simone Ecker retweeted
Human immune systems can only be understood by studying diverse human populations. In @naturemethods we call for more inclusive human immunology research rdcu.be/ckLzn
Simone Ecker retweeted
Wow, another amazing epigenetic clock study by Steve Horvath et al.
They find that methylation levels, set at birth, predict maximum lifespan in mammals. Genes proximal to methylation sites tend to be associated with development, metabolism.
biorxiv.org/content/10.1101/…
Simone Ecker retweeted
1/11 Thrilled to FINALLY share:
🚨 Elevated in vivo IL-17A activity in human active #TB vs latent/cured TB 🚨
Supports targeting this cytokine axis to reduce disease pathology & transmission. #tuberculosis
Paper @ScienceTM: bit.ly/3el8M9e
Explainer thread:👇
Simone Ecker retweeted
Using inter-individual variation in TF binding and its downstream effects in primary neutrophils as "nature's perturbation experiment" to interpret the function of immune GWAS SNPs.
Our joint work with @nicolesoranzo's team,
@BiolaMJavierre, @Ciavenasc
nature.com/articles/s41467-0…
Simone Ecker retweeted
Hope you had a good break & Happy 2021! We are back with more weekly webinars! The first one is by Stephan Beck UCL. Stephan will be speaking on "Connecting Dots for Genomics Medicine" next Tuesday, 12th of Jan at 16.30 GMT join us with the link👉 qmulepigenetics.com/webinars pl share
Simone Ecker retweeted
.@wellcomegenome #PersonalGenomics event w/ stellar keynotes @23andMe @joannamtn & @Stanford @SnyderShot among many other world renown scientists.
Privileged to form part of the organising committee for such an amazing #international #conference.
This Post is from an account that no longer exists. Learn more
Simone Ecker retweeted
Many congratulations to @AfonsoHenriques, @Ismail_Moghul, @awebster90, @SimoneEcker, @JavierHerrero7, @StephanBeck6 and all the PGP-UK team @PGPUK_genomes on the publication of GenomeChronicler just out in Fontiers in Genetics!
frontiersin.org/articles/10.…
Simone Ecker retweeted
Launching in January 2021 and now open for submissions, Nature Aging will publish research from across the basic biology of aging, geriatrics, and gerontology to the impact of aging on society. Visit us online to learn more, register for E-Alerts from launch, and submit research.
Simone Ecker retweeted
PGP-UK Health Assessment in support of COVID-19 related research.
A Big Thank to our participants who proved themselves again as valuable Citizen Scientists by taking part in the Assessment.
pgpukblog.wordpress.com/
Simone Ecker retweeted
My editorial paper entitled, "No raw data, no science: another possible source of the reproducibility crisis". When I feel the results are too beautiful, I requested raw data before sending it out for review. 40 out of 41 did not send me the right data.
molecularbrain.biomedcentral…
Simone Ecker retweeted
Our new paper from @karolinskainst out today in @eLife "Longitudinal trajectories, correlations and mortality associations of nine biological ages across 20-years follow-up". #aging #geroscience
doi.org/10.7554/eLife.51507
Simone Ecker retweeted
With ongoing intense efforts in #aging science to turn back the clock, this review on #epigenetic modulation is both timely and outstanding nature.com/articles/s41580-0… @NatRevMCB by @salkinstitute and collaborators
