Srinivas Chamakuri retweeted
Drs. @Srini_Chamakuri @bcmhouston, F. Li, P. Dosa @UMNews, R. Davey @BU_Tweets et al discovered a small molecule that inhibits #Ebola entry, improves #survival and reduces clinical signs in animal model of the condition. @NatureComms blogs.bcm.edu/2026/09/15/hig…
Srinivas Chamakuri retweeted
@Srini_Chamakuri @bcmhouston, F. Li, P. Dosa @UMNews et al discovered a compound that blocks #Ebola virus entry into cells and improve animal model outcomes @NatureComms medicalxpress.com/news/2026-…
Srinivas Chamakuri retweeted
I am honored to begin my role as Director of the Center for Drug Discovery at Baylor College of Medicine. Exciting times ahead. #DrugDiscovery #dels
Srinivas Chamakuri retweeted
Congratulations, Dr. @DamianYoung29 @bcmhouston, recipient of a 2024 Catalyst for Discovery Program Grant for his project "Innovation in DNA-Encoded Chemistry Technology to Enable More Effective Ligand Discovery" @WelchFoundation @BCMCancerCenter
Srinivas Chamakuri retweeted
Is a #birthControlPill for #men in the horizon? Drs. M Matzuk, A Ku, C Sutton et al have taken a step toward that direction. @bcmhouston @bcmgenetics #fertility
New findings in Science "provide substantial support that targeted nonhormonal approaches can be effective in the development of a male contraceptive pill."
Learn more in a new #SciencePerspective: scim.ag/7bO
Srinivas Chamakuri retweeted
A new Science study in mice underscores the potential of STK33—a protein essential for male fertility in humans and mice—as a druggable target, offering a promising avenue for the development of nonhormonal and reversible male contraceptives. scim.ag/74U
Another example of Systematic Chemical Diversity (SCD) from our labs. Expanding Complex Morpholines.
pubs.acs.org/doi/10.1021/acs…
Srinivas Chamakuri retweeted
Thanks to Asher Mullard for guiding the discussion to relevant topics.
From basic research to budding biotechs, under one roof with Stuart Schreiber bit.ly/3Tj5yaK
@SchreiberStuart discusses his plans to tackle inefficiencies in the translation of biomedical research, through the newly launched for-profit institute Arena BioWorks
Srinivas Chamakuri retweeted
Chemical tools to expand the ligandable proteome: diversity-oriented synthesis-based photoreactive stereoprobes dlvr.it/T3TTwF
Srinivas Chamakuri retweeted
Dr. Damian Young, is a med-chemist who works on drug discovery. He’s the Assistant Professor of Pharmacology and Chemical Biology at Baylor College of Medicine, the Assistant Professor of Pathology at the Center for Drug Discovery, and much more. Read the Panel for more info 😉
Srinivas Chamakuri retweeted
Check out our latest publication in the Journal of Medicinal Chemistry about the use of DNA encoded libraries to discover novel beta-lactamase inhibitors.
doi.org/10.1021/acs.jmedchem…
@JiayiFan217 @tgpalzkill
Srinivas Chamakuri retweeted
Just when you think JQ1 is out, it gets pulled back in… and with a longer half-life! Introducing JQ1-D.
pubs.acs.org/doi/10.1021/acs…
Srinivas Chamakuri retweeted
Some work by my labmates @PalzkillLabBCM that I helped with during my PhD went live over the holidays! We used DNA-encoded libraries to find highly potent inhibitors of two prominent carbapenemases, NDM-1 and OXA-48.
pubs.acs.org/doi/abs/10.1021…
Srinivas Chamakuri retweeted
Heterocyclic merging of stereochemically diverse chiral piperazines and morpholines with indazoles (Chamakuri et al. @Srini_Chamakuri, and @DamianYoung29 @bcmhouston) onlinelibrary.wiley.com/doi/…
Happy to share our recent paper of Heterocyclic Merging of Stereochemically Diverse Chiral Piperazines and Morpholines with Indazoles - Chemistry A European Journal - Wiley Online Library chemistry-europe.onlinelibra…
Srinivas Chamakuri retweeted
Check out our latest paper describing non-covalent and non-peptidic Mpro inhibitors derived from DEL screening!
nature.com/articles/s42004-0…
I greatly enjoyed leading the study that uncovered non-covalent, non-peptidic inhibitors for SARS-CoV-2 Mpro using DEL Technology. Our research showcases DELTec's versatile ability to identify small molecule modulators for diverse targets, even without prior structural insights.
A new type of SARS-CoV-2 Mpro inhibitor is discovered by DNA-encoded chemical library screening, reported by @bcmhouston & @DamianYoung29 & @Srini_Chamakuri & @PalzkillLabBCM nature.com/articles/s42004-0…
Srinivas Chamakuri retweeted
Big shot out to the amazing work of the @HoveydaLab for their methodology to make tri-substituted macrocycles with control of geometry using ring-closing metathesis. We wrote a News and Views commentary in Nature Chemistry.
nature.com/articles/s41557-0…
Srinivas Chamakuri retweeted
Postdoctoral training opportunity in my lab for synthetic chemists or chemical biologists to discover molecular glues and bifunctional compounds using DNA-barcoded compounds. If interested, please read and respond here: broadinstitute.wd1.myworkday…
Srinivas Chamakuri retweeted
Today we embrace Dr. Damian Young, who is a medicinal chemist, and the Assistant Professor of Pharmacology and Chemical Biology at Baylor College of Medicine where his lab focuses on fragment based drug discovery.
#Blackinchem #chemistry #blackchemists #STEM #blackandstem
