Synthetic Neurobiology Lab @BCMhouston & @RiceUniversity. Our mission is to develop new molecular tools to accelerate the pace of biomedical discovery
Houston, TX
Joined May 2019
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We're hiring! 4 open roles at the St-Pierre Lab (Baylor College of Medicine), building next-gen optical & electrophysiology tools to read and control brain activity. 🧵
Staff Scientist: Protein Engineering. Lead characterization of voltage indicators and optogenetic silencers using electrophysiology and two-photon imaging. PhD + 3 yrs postdoc experience required. Link ↓ jobs.bcm.edu/job/Staff-Scien… #ProteinEngineering
Research Associate: Electrophysiology. Run ephys + optical imaging experiments to characterize voltage indicators and optogenetic silencers. Master’s + 3 yrs; slice or neuron ephys and rig experience required. jobs.bcm.edu/job/Research-As… #Ephys
#MayThe4th announcement: JEDI-2P was not The Last Jedi ⚔️! Introducing JEDI3sub & JEDI3hyp, the best GEVIs in this galaxy for reporting subthresholds voltage dynamics under two-photon illumination🔬#GEVIs. Check out our @naturemethods paper: nature.com/articles/s41592-0…
Huge thanks to our amazing collaborators @IBENS_ENS
(Laurent Bourdieu, Vincent Villette, Jon Bradley and team), Na Ji @UCBerkeley, Brice Bathellier at l'Institut de l'Audition, and @BarnaDudok and @viajake at @bcm_neurosci. ⚔️Team science at its best!
#MayThe4th be with you! Meet FORCE1s, a new positive‑going, ultrasensitive voltage indicator. Optimized for 2P imaging at slower acquisition speeds, FORCE1s is easy to use on almost any microscope. Bonus: it even powers 2P miniscope experiments!📄Preprint: biorxiv.org/content/10.64898…
High praise to the best collaborators in the Galaxy, who deployed FORCE1s in vivo, including the teams of @WikiZong (2P miniscope), Na Ji (FACED), @IBENS_ENS (Laurent Bourdieu, Vincent Villette, Jon Bradley), and @viajake @bcm_neurosci. Contact Dr. St-Pierre for FORCE1s.
Grab some JEDI3 plasmid or AAV from Addgene and join the JEDI order. addgene.org/browse/article/2…
🚨 We’re hiring! The St-Pierre Lab at Baylor College of Medicine has exciting opportunities:
🔬 Postdoctoral position
👩🔬 Staff position
Work on cutting-edge electrophysiology and optical tools to advance neuroscience!
See: shorturl.at/uim4d
#Neuroscience #Ephys #PostdocJobs
The Force Awakens at #Sfn2025 ! Join us tomorrow AM for poster LBP038: introducing FORCE1s, a positive-going GEVI engineered by the St-Pierre lab for ultrasensitive voltage detection. Stunning in vivo results from the Reimer, Bourdieu, @NaJiBerkeley, and Weijian Zhong labs.
The Return of the JEDI! St-Pierre lab poster LBP037 tomorrow AM @ #Sfn2025: unveiling JEDI3 — next-gen Genetically Encoded Voltage Indicators (GEVIs) for enhanced detection of subthresholds under 2P. Great collaboration with the Bourdieu,@NaJiBerkeley, @BarnaDudok & Reimer labs
Excited to share our latest paper, where the @EmilianiLab used our #JEDI-2P-Kv indicators for high-SNR scanless 2P voltage imaging of multiple cells in vivo, and combined voltage imaging and optogenetics. Don't miss the 17 supplementary figures 😲! doi.org/10.1038/s41467-024-4…
🚀 Exciting Opportunity Alert! 🚀 Join our dynamic team at St-Pierre Lab at BCM as a Postdoctoral Researcher! Work on cutting-edge projects and contribute to groundbreaking discoveries. Apply now and be part of our innovative research community! #Postdoc #Opportunity
Putting the final touches on my upcoming talk for the @CNPviralvectors satellite meeting at the @CAN_ACN conference, all while enjoying the stunning views of beautiful @CityofVancouver, my beloved home country of Canada!
Congrats to @HelenXiaoyuLu, an outstanding recent lab alum who won a @RiceSSPB thesis award 🏆! Xiaoyu is now a Scientist at @AllenInstitute and so couldn't attend. I attempted to accept on her behalf, disguised with her face on cardboard🎭, but my cover was blown quickly!
@HelenXiaoyuLu couldn't come to Houston to accept her @RiceSSPB thesis award, so I brought it to her in Seattle!
🥂Celebrating 5 incredible years with Shujuan Lai in our lab @bcm_neurosci. She's been pivotal in developing photostable fluorescent proteins and our SPOTlight single-cell screening platform. She gave an inspiring speech🎤emphasizing the power of grit in achieving dreams.
Dr. Francois St-Pierre led an illuminating session on "Advanced Concepts in Voltage Imaging" at the Optogenetics and Wavefront Shaping program in Paris. Unlocking new insights into brain functioning! #Neuroscience #Optogenetics #ParisConference 🌟
