Statistical geneticist. Professor of Human Genetics and Biostatistics at the University of Pittsburgh. Assiduously meticulous. Mastodon: @StatGenDan@fediscience
Pittsburgh, PA
Joined July 2016
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Daniel E. Weeks retweeted
Please RT!
🧬Postdoc Opportunity in Statistical/Computational Genetics!🧬
Join our team in Human Genetics @PittPubHealth! Focus: Genetic etiology of cardiometabolic disease in Samoans & Pacific Islanders. Collaboration with @CharlestonCWKC
tinyurl.com/pitthugen
#Postdoc #Academicjobs
Daniel E. Weeks retweeted
🧬Postdoc Opportunity in Statistical/Computational Genetics!🧬
Join our team in Human Genetics @PittPubHealth! Focus: Genetic etiology of cardiometabolic disease in Samoans & Pacific Islanders. Collaboration with @CharlestonCWKC
tinyurl.com/pitthugen
#Postdoc #Academicjobs
Daniel E. Weeks retweeted
Feeling frustrated when trying to put together your dbGaP data submission? @StatGenDan and I are excited to announce our new R package, #dbGaPCheckup, which we designed to help YOU with this complex process! 🧵(1/n) #Rstats #Genetics #dbGaP #DataQC #DataSharing #OpenScience
Daniel E. Weeks retweeted
We are excited to share our new work @Nature, led by @Lenka_Dohnal, uncovering a gut-brain pathway that regulates the motivation for #exercise. (1/7)
nature.com/articles/s41586-0…
Daniel E. Weeks retweeted
We released a commentary on Ioannidis et al (2021) as a preprint. To date the settling of Polynesian islands, they inferred split times using IBD segments shared between modern genomes. We show that their estimator is biased to be ca. 300 years too old. doi.org/10.1101/2022.12.01.5…
Daniel E. Weeks retweeted
Just how poorly does a polygenic score for LDL-C perform in a population that isn’t represented in its construction? Come check out my poster at #ASHG22 this afternoon (Wed) 3-4:45 to find out and chat!
Daniel E. Weeks retweeted
Congratulations Dr. Carlson and team!!!@jenccarlson
If @jenccarlson and her team had only been looking in genetic databases with people of European ancestry, they would have missed a big cholesterol discovery, reported this week in @HGGAdvances. bit.ly/3F1hnf6
ALT Photo and quote from Dr. Jenna Carlson: “It was through the generosity of thousands of Polynesian people that we were able to find this variant, which is a smoking gun that will spark new research into the biology underlying cholesterol.”
Daniel E. Weeks retweeted
They say deep learning is just curve fitting. But how good is it in curve fitting exactly? Are DNNs as good as, or even better than, classical curve-fitting tools, e.g., splines and wavelets? We studied this carefully in arxiv.org/abs/2204.09664 and found many cool insights 🧵 1/
Daniel E. Weeks retweeted
We are excited to share this research in which we found a super cool association with a stop-gain variant in BTNL9 and lower HDL-C and higher triglycerides🧵 (1/n)
bit.ly/3VoiDOY
New! @jenccarlson et al. identify a BTNL9 variant associated w/reduced HDL-C and increased triglyceride levels #OA
bit.ly/3VoiDOY
Daniel E. Weeks retweeted
Very bad news: Accurate substitution modelling assumes all variables are in the same units.
But it is most common for studies to examine food in grams/servings while adjusting for total energy in calories.
This. Breaks. Everything.
doi.org/10.1093/ajcn/nqac188
9/12 #EpiTwitter
Daniel E. Weeks retweeted
Interesting paper reporting a stop gain variant in BTNL9 associated with reduced HDL and increased triglycerides. This variant is seen ~22% of Samoans (with many homozygotes) but extremely rare (<0.01%) or absent elsewhere in the world.
New! @jenccarlson et al. identify a BTNL9 variant associated w/reduced HDL-C and increased triglyceride levels #OA
bit.ly/3VoiDOY
Daniel E. Weeks retweeted
New! @jenccarlson et al. identify a BTNL9 variant associated w/reduced HDL-C and increased triglyceride levels #OA
bit.ly/3VoiDOY
Daniel E. Weeks retweeted
Why do complex traits differ in their genetic architecture?
Surprisingly, we find that two simple scaling laws explain why the number, effect sizes and frequencies of causal variants differ between traits.
Work with @GuyS2747 & @jkpritch.
biorxiv.org/content/10.1101/…
Thread 🧵
Daniel E. Weeks retweeted
For blood pressure control, think outside the kidney
ahajournals.org/doi/10.1161/… potential importance of epithelial sodium channels @PITTRenal @UPMC @tkleyman @BMBlobner
Daniel E. Weeks retweeted
Our Global Health Equity Scholars program is open to US postdoc applicants. If you are interested in Samoa (epidemiology, NCDs, maternal child health), send me a message! @courtneychoy, @AnnaRivara and @oyama_sakura can attest to the fun you would have... medicine.yale.edu/yigh/ghes/
Daniel E. Weeks retweeted
The strongest possible sample size justification is based on an explicit statement of the smallest effect size that is considered interesting. You can't know what the 'true effect size' is - so design a study to detect effects that matter lakens.github.io/statistical…
Daniel E. Weeks retweeted
Ten simple rules for teaching yourself R journals.plos.org/ploscompbi… #datascience #coding #rstats #bioinformatics #ICYMI
Daniel E. Weeks retweeted
Picard programming tip: A computer is like a mischievous genie. It will give you exactly what you ask for, but not always what you want.
Daniel E. Weeks retweeted
Join us for the inaugural M. Michael Barmada Memorial Lecture, in honor of beloved professor Dr. M. Michael Barmada, this Friday in the G23 auditorium. We look forward to having @KECKSchool_USC assistant professor Dr. Enrique Velazquez Villarreal as the keynote speaker.
