@SwuliusLab

Neuronal Cell Biology. CryoEM.

 Hershey, PA
Joined November 2017
  • Tweets340
  • Following451
  • Followers585
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🚨Members of #teamtomo!🚨 We invite you to submit abstracts to our ❄️🔬Cryo-electron Tomography: Progress and Potential session at Microscopy & Microanalysis (M&M) 2025! abstractscorecard.com/cfp/su… @benjaminbarad
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Carter Lab@Carter_Lab6 Feb 2024
If you are interested in joining my group to study how microtubule motors select their cargos (or vice versa) then please see the two adverts below. One is based on neuronal cell biology, the other on reconstitution and cryoEM. nature.com/naturecareers/job… nature.com/naturecareers/job…

Postdoctoral Scientist - Structural Studies - Dr Andrew Carter - LMB 2344 - Cambridge, Cambridges...

Postdoctoral Scientist Salary £39,375 per annum MRC Laboratory of Molecular Biology, Cambridge, UK An opportunity is available for a postdoctoral r...

nature.com
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The "final form" of this beautiful paper is out in @NatureComms now! Hugely honored to be part of this with @_manasi_iyer_ and @ZucheroLab Particularly proud of the 3D serial section EM of myelin. Paper: link.springer.com/article/10…
ZucheroLab@ZucheroLab13 Apr 2023
What controls the morphology of #myelin sheaths to enable them to fine-tune conduction velocity? TL;DR: Calcium (Ca2+) signaling; a.k.a. nature’s ultimate multitasker! Read our new pre-print to find out more, led by grad student @_manasi_iyer_! 🧵👇(1/n)
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Excited to share our latest work published in @PNASNews! Utilizing cryo-ET, we have successfully visualized the force that segments the nucleus. The whole story works out in an imaging-driven approach. #TEAMTOMO
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MPI Dortmund@mpimoph23 Oct 2023
Congrats to our two new #Humboldtians @AvHStiftung Laura Posada from @PeterChemBio1 lab & Ryan Hylton from @Intein lab! They have received the prestigious Humboldt Research Fellowship
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This summer, we announced our #CryoEM Grant Program recipients, and are excited to now share more in-depth conversations with our Gold, Silver & Bronze award winners - @parameciumbrain, @SiyuChen91 & @lisaeshunwilson! See each of their interviews here: ter.li/uk637u

Thermo Fisher Scientific | Cryo-EM Grant Program Recipients

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Chi-Min Ho@mimi1inh7 Sep 2023
Our story wouldn't be complete without sharing our full in situ #CryoET workflow for #malaria parasites, featuring some beautiful schizont-stage parasite-infected red blood cells in the #CryoFIB and one of our favorite tomograms!❄️🔬🧫#teamtomo More here👉tinyurl.com/5n96rkfm
Chi-Min Ho@mimi1inh7 Sep 2023
Excited to share our in situ #CryoET story on the effect of a top antimalarial drug candidate on the translational landscape in #CryoFIB-milled malaria parasites! So proud of this massive team effort with @leonie_anton @_wenjing_cheng_ @mehsehret @davwcbb🥰#officially #teamtomo
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Very excited to share our latest study using cryo-ET to investigate actin filaments in #Apicomplexan parasites. This allowed us to learn where do these filaments originate at the cell tip and how they could be managed down the cell body to power motility! nature.com/articles/s41467-0…

Origin and arrangement of actin filaments for gliding motility in apicomplexan parasites revealed...

Nature Communications - Apicomplexan parasites utilize a unique actomyosin system to mediate motility and host cell invasion. Here, the authors apply cryo-ET to Cryptosporidium parvum and...

nature.com
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Come join the #CryoEM team at Amgen Thousand Oaks! We’re looking for a structural biologist with expertise running high-end electron microscopes and delivering high res single particle cryoEM structures. We also use #MicroED and #xraycrystallography
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Super excited to share the latest pre-print from the Shaffer lab - we mechanistically characterized asymmetric architectural features that enable DNA substrate selection and trans-kingdom conjugation through the cag T4SS. I'm so proud of my amazing team! biorxiv.org/content/10.1101/…

Architectural asymmetry enables DNA transport through the Helicobacter pylori cag type IV secretion...

Structural asymmetry within secretion system architecture is fundamentally important for apparatus diversification and biological function. However, the mechanism by which symmetry mismatch contrib...

biorxiv.org
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📢 Exciting news #teamtomo! We've updated our FakET preprint presenting a new method to simulate cryo-electron tilt-series, with L. Herrmann, @GrohsPhilipp, and @HaselbachLab. To celebrate, we've created a fun movie-style poster. Can you guess the movie? More in the 🧵.
A movie-style poster presenting the research article instead of the original movie poster it was inspired by.

ALT A movie-style poster presenting the research article instead of the original movie poster it was inspired by.

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TomoTwin 0.5 is here 🥳 Enjoy an embedding speed-up of 1.5x to 2x by using masks, get more accurate 🎯 cluster targets through medoids, and become more nerdy 🤓 through developer information snippets. All changes can be found here: tomotwin-cryoet.readthedocs.…
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❄️🔬Triple crown cryo-week @UWBiochem! Into integrated fluorescence #microscopy #cryoFIB #cryoET for in situ #structural #cell-biology? Latest from @JYang22638056, @Pangolininator, @larsonmattr, Veronika, Tilman, Alex H, Alex R, & John @thermosciEMSpec. biorxiv.org/content/10.1101/…

Integrated Fluorescence Microscopy (iFLM) for Cryo-FIB-milling and In-situ Cryo-ET

Correlative cryo-FLM-FIB milling is a powerful sample preparation technique for in situ cryo-ET. However, correlative workflows that incorporate precise targeting remain challenging. Here, we...

biorxiv.org
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Hi all! There seem to be some issues accessing some of the pieces of the July Focus issue even for subscribers, so I am sharing readcube links for all pieces in this thread!
Nature Methods@naturemethods11 Jul 2023
For this Focus issue, we asked experts in bioimaging from around the world to tell us what excited them about the future of bioimage analysis for the next 5-20 years. (1/n) All Focus content can also be found here: nature.com/collections/afjic…
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Please give a big round of applause to @SiyuChen91, @thermofisher's 2023 #CryoEM Grant Program Silver Winner! Siyu is a postdoctoral fellow at @TheVillaLab at @UCSanDiego / @HHMINEWS. Learn about his research proposal here: ter.li/14o1ke

Congrats to Siyu Chen: Silver Cryo-EM Grant Award Recipient

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Congrats, @lisaeshunwilson - @thermofisher's 2023 #CryoEM Grant Program Bronze winner! An @NSF Postdoctoral Fellow in the @LanderLab at @scrippsresearch, Lisa completed her PhD from @UCBerkeley in the @NogalesLab 👏. Learn more: ter.li/14o1ke

Congrats to Lisa Eshun-Wilson: Bronze Cryo-EM Grant Award Recipient

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SwuliusLab retweeted
Chi-Min Ho@mimi1inh7 Jul 2023
And that's a wrap for the #ACA2023 Advanced Topics in #CryoEM & #CryoET Workshop! Thank A huge thank you to all our phenomenal speakers!!! @davidwtaylorjr @therickybaker @FitzpatrickLab @demarco_lab Jae Yang, @DTegunov @zhou_lab @nani_grotjahn @SwuliusLab ♥️❄️🔬
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The desmosome, normally toiling away in obscurity, finds itself on the cover of @NatureCellBio by way the ER! We are excited to see our work in press along with a News and Views commentary by Harmon and @GottardiLab nature.com/articles/s41556-0…
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So happy to finally announce the TomoTwin clustering workflow release! We wanted to optimize the clustering interface to make it truly interactive and easy for users to explore their tomograms using TomoTwin’s information rich embeddings. 🧵👇
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preprint: Mesoscale simulation of biomembranes with FreeDTS: Finally I managed to write a manual, tutorials and a manuscript. Many projects can be done with it. Some proof of concept in the manuscript. Well connected to TS2CG biorxiv.org/content/10.1101/…
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