@TafLab

High risk, high reward research on cellular engineering, CRISPR, miRNAs and synthetic biology

 Weatherall Institute, Oxford
fulga-lab.org/
Joined July 2014
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Fulga LAB retweeted
Addgene@Addgene31 May 2019
Precise regulation of mammalian gene expression by synthetic microRNA silencing-mediated fine-tuners (miSFITs) @TafLab hubs.ly/H0h-6fy0
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Tudor gave a talk on engineering mammalian cells -synthetic receptors, iSBH gRNA control, miSFIT gene tuning system- at Oxford IF's Innovation in Genomics event @if_oxford @MRC_WIMM #innovation #Genomics #IFOGenomics #syntheticbiology
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Just dropped our new preprint online where we used our Tri-C multiway 3C technologies to investigate promoter competition in chromatin self-interacting domains. A revised model for promoter competition based on multi-way chromatin interactions biorxiv.org/content/10.1101/…

A revised model for promoter competition based on multi-way chromatin interactions

Specific communication between gene promoters and enhancers is critical for accurate regulation of gene expression. However, it remains unclear how specific interactions between multiple regulatory...

biorxiv.org
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New work from @TafLab, @TFulga, @YaleMichaels, @MRC_WIMM decouples tRNA promoter and processing activities to enable Pol-II #CRISPR gRNA expression Out now @NatureComms go.nature.com/2YGAKCB
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Congratulations David for the new paper! The authors published their work on engineering highly specific Polymerase II driven tRNA-gRNA expression. These results will enable avenues of research both in genome engineering and basic tRNA biology. nature.com/articles/s41467-0…
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