@Taylor_Lab_KCL

Sir Henry Dale Fellow, King's College London. Synthetic biologist developing artificial nucleic acids (XNA) for precision medicine.

 Cambridge, England
scholar.google.com/citations?user=Hw8COEoAAAAJ&hl=en&oi=ao
Joined February 2009
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  • Followers1.5K
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I'm finally updating group website and I am hoping to take blogging a little bit more seriously. So, question to X: what aspect of directed evolution would you like to hear about? Or what concept you think is often misunderstood in DE?
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Finally out, Falk's paper on the evolution of function starting from single RNA sequences chemistry-europe.onlinelibra… Thanks to Ben Porebski and Chris Johnson for great contributions.
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Hey, #synbio people. Wes Robertson, A good friend of mine and a great scientist is starting his lab @MRC_LMB This is a unique opportunity to have an impact in #synthetic_genomics and work under leadership of talented and ambitious PI. shorturl.at/mnvw9
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I'm currently looking to recruit a PhD student interested in synthetic polymers (ucl.ac.uk/chemistry/study-he…, 1 week left to deadline!) and a postdoc to study models of primordial biology (bit.ly/48OnSOu)
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Porebski et al. hit the motherlode of antibody affinity data by repurposing a DNA sequencer - enough data to both identify better antibodies, and then improve them using machine learning.
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A new MPhil programme at the University of Cambridge will deliver postgraduate training in the search for life’s origins on Earth and its discovery on planets beyond Earth. cam.ac.uk/stories/explore-li… via @Cambridge_Uni

Explore life in the Universe

A new MPhil programme at the University of Cambridge will deliver postgraduate training in the search for life’s origins on Earth and its discovery on planets beyond Earth.

cam.ac.uk
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Alex Taylor retweeted
EngBio IRC@EngBioIRC14 Aug 2023
Come and join us at our popular Cafe Synthetique on Mon 4 Sept, 6pm. Dr Alex Borodavka 'Viruses:Elegance in their Simplicity or Simply Bad News Wrapped in Protein. @AlexBoRNA sign up here meetup.com/cambridge-synthet…
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PDRA opportunity in our group @UCLChemistry to develop & characterise ribozymes that harness primordial chemistries. 28 months, funded by BBSRC & Royal Society; org chem or mol bio background. Apply by 7th August: tinyurl.com/4bhhf2v2
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If you think it’s unacceptable that rapists can freely roam university campuses with no safeguarding measures in place then say #NotOnMyCampus and sign the petition to introduce national guidance on tackling sexual misconduct in higher education 👇🏽 petitions.parliament.scot/pe… – at Glasgow, Scotland

Petition: Introduce national safeguarding guidance on how higher education institutions should...

Calling on the Scottish Parliament to urge the Scottish Government to introduce national safeguarding guidance for dealing with cases of sexual misconduct in higher education institutions, which...

petitions.parliament.scot
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Self-replication is a defining hallmark of all living systems and how it emerged - early on in the origin of life - remains a fundamental question in biology and chemistry. Postdoc opportunity in my lab: nature.com/naturecareers/job… Please RT!
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Great opportunity to learn more about exciting tools for engineering cells and have a fun night out! Prof Mark Howarth on Spy-toolbox! meetup.com/cambridge-synthet… @CamBiochem @EngBioIRC
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Could synthetic biology hold the key to future COVID-19 treatments? Scientists have created artificial enzymes that act like scissors to chop up the SARS-CoV-2 virus. @Taylor_Lab_Cam @cam_fight_covid bit.ly/3TEkeOK

‘Programmable molecular scissors’ could help fight COVID-19 infection

Enzymes are naturally occurring biological catalysts, which enable the chemical transformations required for our bodies to function – from translating the genetic code into proteins, right through to...

cam.ac.uk
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Proud to announce that my first first-author paper is online! We (@Taylor_Lab_Cam, @PhilHolliger and our co-workers) demonstrate how a novel engineered polymerase unlocks efficient synthesis and evolution of therapeutic 2'-modified nucleic acids. nature.com/articles/s41557-0… 🧵(1/n)

A two-residue nascent-strand steric gate controls synthesis of 2′-O-methyl- and 2′-O-(2-methoxyet...

Nature Chemistry - Sterically demanding 2′-modified nucleotides used in antisense therapeutics have thus far been challenging to synthesise enzymatically. Now, it has been shown that mutation...

nature.com
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PhD studentship alert! Do you like birds? I mean, who wouldn't, they're basically little dinosaurs! Wanna understand their brains better? Do you like cool methods, like organoids? Apply here! jobs.cam.ac.uk/job/37121/
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Engineered RNA endonuclease XNAzymes can specifically target individual disease-associated ncRNAs in vitro, with the potential for precision detection or knockdown of individual microRNAs or longer ncRNAs. @Taylor_Lab_Cam @MariaDonde2 @Cambridge_Uni nature.com/articles/s42003-0…
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Alex Taylor retweeted
Tom Ellis@ProfTomEllis12 Sep 2022
Who else remembers this issue of Nature? To say it was an influence on my decision to do synthetic biology is a bit of an understatement. I literally quit my day job after reading this.
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Replying to @sashalevans
PI in the lab 😱
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Alex Taylor retweeted
EngBio IRC@EngBioIRC26 Aug 2022
#CafeSynthetique is back on 5th September! Very much looking forward to welcoming back the Cambridge #SynBio and #EngineeringBiology community at our monthly pub meetups. engbio.cam.ac.uk/news/cafe-s…
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Alex Taylor retweeted
Chris Wan@ChrisJWan25 Aug 2022
The first preprint from my PhD is now live! biorxiv.org/content/10.1101/… a short thread 🧵 (1/n)

Cryo-EM structure and functional landscape of an RNA polymerase ribozyme

The emergence of an RNA molecule capable of replicating itself and other RNA sequences is a central pillar of hypotheses regarding the origin of life[1][1],[2][2]. In vitro evolution has yielded...

biorxiv.org
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2 PhD positions in computational/experimental protein design & engineering for #synbio available in my lab @univgroningen 　　　　　　　　　🧪➡️🛠️ 🇳🇱　👩‍🎓　▶️　　↗️　　　 ↘️ 🚲　2️⃣　▶️　👩‍🔬　　　　　 👨‍💻 🇳🇱　👨‍🎓　▶️　　↖️　　　 ↙️ 　　　　　　　　　🧬⬅️🎨 bit.ly/3td40Ca 🧵⬇️
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