MD. Medical Oncologist. Focused on innovative Lymphoma & Myeloma care. Opinions solely personal views.
Luzern, Schweiz
Joined April 2015
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Here you can see how important phase III trials are. Preclinical rationale, early results - almost everything was in favor of pelacarsen. RIP.
novartis.com/news/media-rele…
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On Friday evenings after the stock market closes, the news that nobody is supposed to see come out.
LAG3 fail.
investor.regeneron.com/news-…
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Dose-response study on exercise, sleep and nutrition for life expectancy. With 7 hours of sleep and 30 minutes of exercise per d, the entire potential benefit is achieved. Healthy food is of surprisingly little significance. Sleep and exercise surpass everything else. @TheLancet
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Tafasitamab + Lenalidomide + R-CHOP. Puh. Hope to see the results soon. Key question: Will CD-19 CAR-T still work for patients that relapse early after Tafa? I am not so sure. #DLBCL
Donor 7069 carried TP53 mutation (Li-Fraumeni syndrome) - One donor, 67 clinics, 14 countries, at least 197 children
Terrible. Unbelievable.
investigations.news-exchange…
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Plasma fractionation companies entering a golden decade. Expanding indications are driving unprecedented demand.
$GRIFOLS $CSL $ADMA $HAE
The picks & shovels of the CART & bispecific antibody boom. This deserves
@JacobPlieth @bradloncar deep dives.
One of the most critical aspects of modern care for myeloma patients is providing adequate IgG replacement, particularly for those treated with bispecific antibodies and CAR-Ts. My thoughts and recommendations are below.
rafaelfonseca.substack.com/p…
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Current H3N2 flu wave now dominant in Europe.
Key facts:
🚨Vaccine effectiveness protects vs. severe disease
✅Antivirals (oseltamivir, baloxavir) remain effective
💉Vaccination + early treatment for high-risk groups important.
Stay safe everyone!
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Metamizol (Novalgin) prophylaxis retrospective comparison: 0% CRS grade ≥2 vs 36% with acetaminophen. ZERO tocilizumab needed vs 44%. Interesting signal from small Brazilian study (n=14) with bispecifics. #ash25 @EricaLammerhirt
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Impressive. New standard of care. Without a doubt.
Epcoritamab + R2 shows major breakthrough in relapsed/refractory follicular lymphoma!
✅ 95.7% response rate (p<0.0001)
✅ 79% reduction in progression risk (HR 0.21, p<0.0001)
This triple combo significantly outperformed standard R2 treatment ir.genmab.com/news-releases/…
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Ondansetron is not enough.
“It is presented annually on behalf of the billions of football loving people from around the world to distinguish an individual who exemplifies an unwavering commitment to balancing peace and unity throughout the world through their notable leadership and action. And therefore, FIFA awards the 2025 FIFA world peace prize football unites the world to Donald J. Trump, president of the United States of America in recognition of his exceptional actions to promote peace and unity around the world”
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The science is clear. Now it’s on us to protect our kids. HPV vaccine works. #gardasil
Fantastic.
One remark: We also protect the lives of our boys. Many other cancers are associated with HPV: penis, anus, ENT. Vaccines work.
Australia just recorded zero cervical cancer cases in women under 25 - for the first time since records began in 1982.
This is what happens when a country commits to HPV vaccination and screening. We protect our girls and save lives.
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This will be something we remember. #ASH25 First in vivo CART data. Crazy stuff. Congrats, @KeloniaTx
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