Three months ago, 149 countries came together to adopt a new Political Declaration on HIV and AIDS. This week at #UNGA81, UNAIDS has been asking: What will it take to turn those commitments into results — and what does UNAIDS need to look like to help make that happen? Yesterday, UNAIDS brought governments and partners together with Botswana and the Netherlands for a ministerial roundtable on the transformation of the Joint United Nations Programme on HIV/AIDS. The conversation focused on how a transformed UNAIDS can remain fit for purpose — continuing to provide political leadership, coordination and support for countries and communities as the global HIV response enters a new phase. That conversation sits within a much bigger agenda. From sustainable financing and tackling inequalities to health sovereignty, local production and equitable access to innovation, one question has run through the week: how do we build HIV responses that countries can lead and sustain? The HIV response also has lessons to offer far beyond HIV — from pandemic preparedness and community leadership to making sure scientific progress reaches the people who need it. Angeli Achrekar, UNAIDS Deputy Executive Director, Programmes, also joined Côte d’Ivoire’s high-level conversation on health sovereignty, health financing and universal health coverage, adding to the week’s focus on sustainable, country-led health systems. And later in the day, the signing of a Protocol of Agreement between the Government of Benin and the UNAIDS Secretariat put that country-led partnership into practice. The commitments have been made. Now comes the work of turning them into lasting results — and ensuring UNAIDS is ready to help make that happen. That is the conversation UNAIDS has been bringing to #UNGA81.