@VasuLabUCSF

Cancer signaling, (single cell) genomics, and functional genetics, with an emphasis on better diagnostic tests and treatments for neurofibromatosis.

 San Francisco
vasudevanlab.ucsf.edu/
Joined October 2022
  • Tweets20
  • Following89
  • Followers94
3Media
Delighted to host the first annual @VasuLabUCSF holiday party - grateful to work with these people every day.
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It's official — the Vasudevan Lab received its first @NIH_NCI R01 to study neurofibromatosis tumor suppressors in nerve sheath tumors! Grateful to @UCSFRadOnc @NeurosurgUCSF @UCSFCancer @ChildrensTumor @ntapresearch @GilbertFamilyFd. It takes a village.
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Exciting new paper by @VasuLabUCSF et al! "IFN signaling is associated with radiotherapy response in malignant peripheral nerve sheath tumors" jci.org/articles/view/195652 @NeurosurgUCSF @UCSFHospitals
Journal of Clinical Investigation
@jclinicalinvestMar 4
This study is directly relevant to the clinical care of patients with the most common malignant tumor of the peripheral nervous system, while providing fundamental biological insight👇 Harish N. Vasudevan @VasuLabUCSF & team @UCSF reveal transcriptional, functional genetic, and cellular mechanisms of interferon signaling that underlie radiotherapy response in people with #MPNST: doi.org/10.1172/JCI195652
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This study is directly relevant to the clinical care of patients with the most common malignant tumor of the peripheral nervous system, while providing fundamental biological insight👇 Harish N. Vasudevan @VasuLabUCSF & team @UCSF reveal transcriptional, functional genetic, and cellular mechanisms of interferon signaling that underlie radiotherapy response in people with #MPNST: doi.org/10.1172/JCI195652
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Vasudevan Lab retweeted
JCI insight
@JCI_insight6 Oct 2025
NF1 is frequently mutated in #glioblastoma, yet therapies targeting this alteration often fall short. @VasuLabUCSF & team @UCSF now show NF1 mutant glioblastomas exhibit prognostic signatures with distinct sensitivity to MEK inhibition: insight.jci.org/articles/vie…
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Excellent time giving grand rounds last week @UMRogelCancer with old friends @gouthamnarla and new ones @castro2355_mg @UCSFCancer @NeurosurgUCSF
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Happy 4th of July - to celebrate, we asked if there is meaningful heterogeneity within somatic NF1 mutant glioblastomas? We think so biorxiv.org/content/10.1101/… As always, appreciate everyone that made this work possible @NeurosurgUCSF @UCSFCancer @ntapresearch @ChildrensTumor

Multiplatform molecular profiling and functional genomic screens identify prognostic signatures and...

NF1 is recurrently mutated in glioblastoma yet the molecular landscape and efficacy of targeted therapies remain unclear. Here, we combine bulk and single cell genomics of human somatic NF1 mutant,...

biorxiv.org
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A delightful time catching up with 10 of NTAP’s 18 Francis S. Collins Scholars & their mentors while in Brussels @ChildrensTumor. Thank you all for your dedication to moving the needle in NF1 research! #NFCON24 #endNF
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Sunrise-ish run through brussels - enjoying every part of the annual @ChildrensTumor meeting #nfcon24 with friends from @NeurosurgUCSF @ntapresearch
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Excited that our DoD New Investigator Award (cdmrp.health.mil/nfrp/awards…) is officially funded - thanks to everyone that helped make this happen @CDMRP @domespo @simanshu and time to get to work!
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A pleasure to review the therapeutic landscape for NF-1 with my future colleague @bnamd87 rdcu.be/dG8Lq
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Additionally, in a study led by @VasuLabUCSF & @LabRaleigh, researchers demonstrate how NF-1 mutant Schwann cell tumors undergo malignant transformation, identifying new potential strategies against treatment resistance: nature.com/articles/s41467-0… @UCSFCancer #neurofibromatosis

Functional interactions between neurofibromatosis tumor suppressors underlie Schwann cell tumor...

Nature Communications - The molecular mechanisms underlying malignant transformation of the Schwann lineage in Schwann cell tumours remain to be explored. Here, the authors suggest that NF2...

nature.com
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New featured image on our homepage! nature.com/ncomms/ 3 papers on schwannomas, tumors of the nervous system derived from Schwann cells @VasuLabUCSF @LabRaleigh @sjohnliu #CancerResearch @NatResCancer nature.com/articles/s41467-0… nature.com/articles/s41467-0… nature.com/articles/s41467-0…
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Very proud of @LexiHaugh for her analysis of targeted DNA sequencing in cutaneous melanoma: biorxiv.org/content/10.1101/… @ad1600

Targeted DNA Sequencing of Cutaneous Melanoma Identifies Prognostic and Predictive Alterations

Importance Cutaneous melanoma (CM) can be molecularly classified into four groups: BRAF mutant, NRAS mutant, NF1 loss, and triple wild type (TWT) tumors lacking any of these three alterations. In the...

biorxiv.org
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Delighted to share that our work looking at functional interactions between neurofibromatosis tumor suppressors is officially accepted: rdcu.be/dvPyh
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Looking forward to #SNO2023 presentation by #FrancisSCollinsScholar @VasuLabUCSF presenting innovative approaches to targeting NF1 loss in nervous system tumors @NeuroOnc @NTAPresearch @HopkinsMedicine #NF
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Our manuscript investigating bulk and single cell genomics of melanoma brain metastases is now online! Many thanks to everyone that made this work possible jamanetwork.com/journals/jam…

Molecular Features of Resected Brain Metastases and Clinical Outcomes

This cohort study evaluates how bulk and single-cell genomic features of melanoma brain metastases are associated with clinical outcome and treatment response.

jamanetwork.com
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Vasudevan Lab retweeted
The Pike Lab@pike_lab17 Aug 2023
So pleased to see our work in @NatureComms, led by @SkakodubAnna, @hswalch, and @KathrynTringale, with @nikolausschultz, describing the genomics and clinical outcomes of a large set of patients with NSCLC brain metastasis. @MSKCancerCenter @MSK_RadOnc rdcu.be/djJ2f
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Big congratulations to @LexiHaugh on her ASCO YIA! Excited to make some progress on (NF1 mutant) metastatic melanoma
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The Vasudevan Lab makes its first twitter post: Excited to share our preprint looking at functional interactions between NF tumor suppressors assets.researchsquare.com/fi…
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