@Wei_Lab_WISC

Wei Lab in the Biochemistry Department at the University of Wisconsin–Madison @UWBiochem https://xitter.cf/t.co/h7olsIZrCT

Joined May 2020
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  • Followers1.5K
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Another slam dunk evidence on the association of BAT activity and health in humans. Despite all this, I still hear from reviewers that BAT in humans isn't important 🤬 nature.com/articles/s41586-0…

Artificial intelligence-enabled clinical phenotyping of human brown fat

Nature - Artificial intelligence-enabled quantification and analyses of brown adipose tissue (BAT) activity uncover links between BAT and a healthier metabolic profile along with lower rates of...

nature.com
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Please spread the word on hiring in our department. We are searching broadly but particularly interested in Systems and Synthetic Biology. I am chairing this faculty search, please feel free to reach out if you have any questions.
UW–Madison Biochem@UWBiochemOct 8
Deadline Oct. 15: We are hiring for a professor at any level to join our creative and dynamic community. Candidates in all areas of #biochemistry will be considered, and we are particularly interested in candidates in systems and synthetic biology. jobs.wisc.edu/jobs/assistant…
Poster for job ad. Read further details at jobs.wisc.edu. Job number JR10012489.

ALT Poster for job ad. Read further details at jobs.wisc.edu. Job number JR10012489.

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Cutting the ribbon to mark the start of my new lab in the Molecular Biology Dept at UTSW! Great to share this special moment with my wife @hoiseetsao, Ralph and the DeBerardinis lab, @Transactivator, and @julie_mirpuri My first lab member Annie already hard at work!
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Pankaj kapahi@kapahi_pankajAug 27
The Kapahi Lab at Stanford is recruiting two Postdoctoral Researchers to lead innovative projects investigating the biology of brain and ovarian aging and the connections between reproductive aging, systemic health, and longevity. postdocs.stanford.edu/prospe…
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Lamming Lab@LammingLabJul 27
I am delighted to be able to share the latest study from the @LammingLab, “Lifelong restriction of dietary valine has sex-specific benefits for health and lifespan in mice” led by former graduate student @mariahcalubag!
🤖 Made with AI
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Congratulations to Professor Monica Neugebauer, who has been selected as a 2026 Beckman Young Investigator! Learn more about how the award will further Neugebauer's work, which aims to expand the chemical capabilities of living systems: biochem.wisc.edu/2026/06/29/…

Neugebauer Selected as 2026 Beckman Young Investigator

With the award, Neugebauer aims to expand the chemical capabilities of living systems.

biochem.wisc.edu
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Long Lab@longlabstanfordJun 25
In @AnnualReviews @Shuke_Xiao and I synthesize two disparate observations (protein lactation and metabolite N-lactoylation) into a coherent framework. We argue that a common function is in information transfer and cellular memory- turning transient states to stable chemical marks
Shuke Xiao 肖舒克@Shuke_XiaoJun 23
Happy to share a review article wrote by me, Jon, and Andrew on an emerging field: Lactate as a Chemical Modification on Proteins and Metabolites - go.shr.lc/4eq0Ani

Lactate as a Chemical Modification on Proteins and Metabolites

Lactate's role in biochemistry and physiology has attracted considerable biochemical interest for over a century. Beyond its classical description as a glycolytic byproduct, lactate is now recognized...

annualreviews.org
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Tim Kenny@TimCKennyJun 17
As we approach the six-month mark since opening our doors, I'm excited to share our lab website and introduce our team at @SinaiHeartBlood @IcahnMountSinai. Check out what we've been up to and reach out if you're interested in joining us or collaborating! timothyckennylab.com

Timothy C. Kenny Laboratory

timothyckennylab.com
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In the W-S lab's first preprint, we describe how genomic language models know something about RNA thermodynamics. Though we think this is cool, things get tricky! A growing practice for interpreting LMs is to perturb input tokens, often called "Categorical Jacobian": 👇
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We are recruiting one postdoc fellow and one Junior Specialist (for those finishing college and planning to pursue a PhD) in regenerative biology and extreme physiology. scvrb-core.ucsf.edu/~huang/l… Please spread the news. Interested candidates can email me directly.
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Long Lab@longlabstanfordApr 29
Congratulations @Shuke_Xiao and our colleagues Leslie Leinwand @CUBoulder and @DrYongXu1 whose🐍🐍🐍 work is featured on the cover of this month’s @NatMetabolism “Satiating serpents”! @Stanford_ChEMH @StanfordPath
Nature Metabolism
@NatMetabolismApr 28
✨New issue✨ Check out the latest in #Metabolism research from across all disciplines. Read about the #GeneticsOfObesity, #DietaryFoodIntake, #PythonMetabolomics, #Irisin, #PancreaticCancer, #IsletEpigenetics, #Immunometabolism and many more topics! 🐭👥 nature.com/natmetab/volumes/…
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Pankaj kapahi@kapahi_pankajApr 26
Postdoctoral Researcher positions-Kapahi lab - Buck Institute - 🚀 looking for two postdocs to lead cutting-edge studies on nutrient signaling, senescence, & aging — combining multiple models ( ucsf &Buck) buckinstitute.applytojob.com…
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Lawrence Kazak@kazaklabApr 22
For 40+ years, we’ve known how UCP1 drives thermogenesis—but how UCP1-independent pathways are activated remained unknown. Thrilled to share our @Nature paper, led by Faiz Hussain, uncovering this mechanism: nature.com/articles/s41586-0…

Glycerol-driven TNAP activation in thermogenesis and mineralization

Nature - Glycerol is an allosteric activator of tissue-nonspecific alkaline phosphatase (TNAP), activating the futile creatine cycle.

nature.com
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Long Lab@longlabstanfordMar 20
The first approved GLP1 (Byetta) came from a desert reptile, the Gila monster. Inspired by this, our work on Burmese pythons 🐍🐍 is now out @NatMetabolism. An “extreme”-ly fun collaboration with Leinwand and @DrYongXu1. Congratulations @Shuke_Xiao! nature.com/articles/s42255-0…

Python metabolomics uncovers a conserved postprandial metabolite and gut–brain feeding pathway

Nature Metabolism - Leveraging pythons as an extreme model of feeding and fasting behaviour, this study uncovers para-tyramine-O-sulphate as a conserved postprandial metabolite that links nutrient...

nature.com
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Long Lab@longlabstanfordMar 20
A first in class PTER inhibitor exhibits anti obesity activity (in mice)- and importantly, via a mechanism distinct from, and additive with, existing GLP1-RAs. Fun collaboration with Gray lab now out @CellChemBiol. Congratulations team! @Stanford_ChEMH cell.com/cell-chemical-biolo…
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University of Utah, Center for Metabolic Health (CMH), Postdoctoral Rising Stars in Metabolism, Sept 2nd, 2026 If you are a postdoc with an exciting METABOLISM story, apply using the QR code by April 24th. Please share with your colleagues.
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Long Lab@longlabstanfordJan 30
GLP-1 drugs transformed obesity treatment. But they don’t work for everybody. What else regulates body weight? In 2024, we linked the BMI-associated enzyme PTER to a non-GLP-1 pathway. Now: first-in-class PTER inhibitors with efficacy in mice. Link here: biorxiv.org/content/10.64898…
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Vatsan Raman@vatsanramanJan 15
Phages shape microbial ecosystems on Earth—but what about in space? In our new study, we show that microgravity aboard the International Space Station reshapes phage–bacteria interactions, evolution, and fitness—with surprising benefits for targeting resistant pathogens on Earth. Great work @phil_huss @chuchitboonthav @RhScientific journals.plos.org/plosbiolog…
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Long Lab@longlabstanfordJan 12
Most people eat small (~1-2% body weight) and frequent (2-3x/day) meals. But Burmese pythons 🐍🐍 can fast for >1 yr and eat 100% of their weight in a single meal. What happens in snakes after eating? What lessons they can teach us about human physiology? biorxiv.org/content/10.64898…

Python metabolomics uncovers a conserved postprandial metabolite and gut-brain feeding pathway

Most mammals consume small and frequent meals. By contrast, pythons are ambush predators that exhibit extreme feeding and fasting patterns and provide a unique model for uncovering molecular mediat...

biorxiv.org
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Long Lab@longlabstanford4 Dec 2025
Today we say goodbye to ⁦@veronical1411⁩, the first brave grad student to join the lab, as she starts the next chapter of her career. Good luck Veronica!!! ⁦@Stanford_ChEMH⁩ ⁦@StanfordPath⁩
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