Immunology, Laboratory Medicine and Pathobiology Lab | UofT/USC/UHN/St Michael's/Buck Institute | Immunometabolism, Mechanoimmunology, Astroimmunology, Aging
Marin County, CA
Joined March 2023
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- Followers139
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Humanity is traveling further into #space. Here, just published in @NatureAging , we discuss parallels between #spaceflight and #aging.
@Furman_Lab
@BuckInstitute
@UHN
rdcu.be/fbymi
nature.com/articles/s43587-0…
Dan and Shawn Winer retweeted
Blast off! Buck scientists make the case for space as a model for accelerated aging. nature.com/articles/s43587-0…
@NatureAging
@furmanbios
@winer_imm_lab
Gut microbiota-derived metabolites as immune modulators in aging and a... sciencedirect.com/science/ar…
Nearly everything you need to know on gut microbiome metabolites, immunity and aging in a single review!
Dan and Shawn Winer retweeted
B cells promote CD4 T cell aging and decline in health-span parameters through intercellular communication and nutrient sensing @SciImmunology @Winer_Imm_Lab @UofT
science.org/doi/10.1126/scii…
Dan and Shawn Winer retweeted
🚨 New publication alert! Research from @UHN reveals a mechanism behind why the immune system declines with age.
B cells—best known for producing antibodies—play a critical role in driving the aging of T cells, fighters of infection.
🔗 Read more: uhnresearch.ca/news/aging-an…
ALT Fluorescence image of T cells and B cells in the spleen. (Image: Winer Lab)
B cells drive CD4 T cell immunosenescence and age-associated health decline | Science Immunology science.org/doi/10.1126/scii…
More than 10years of work from our lab showing that B cells are major players in T cell aging. Thank you to the team!
Dan and Shawn Winer retweeted
🚀 Excited to share our new Nature Reviews Immunology paper: “Astroimmunology: the effects of spaceflight and its associated stressors on the immune system.” We explore how space environment impacts impacts immunity, vital for Moon & Mars missions.
doi.org/10.1038/s41577-025-0…
Dan and Shawn Winer retweeted
Review out in Nature Reviews Immunology: Astroimmunology—how spaceflight reshapes immunity. I’m a co-first author. Co-firsts: Daniel Winer & Huixun Du. Corresponding/senior: Winer, Mason, Choukér & Crucian. @mason_lab doi.org/10.1038/s41577-025-0… #Astroimmunology
Astroimmunology: the effects of spaceflight and its associated stressors on the immune system bit.ly/3J9Oodi
Dan and Shawn Winer retweeted
"Astroimmunology: the effects of spaceflight and its associated stressors on the immune system." Excited for this @Nature Reviews Immunology paper! Summarizes the past few decades of spaceflight and immunology and next steps: nature.com/articles/s41577-0… bravo @KJangkeun @Marissa_R_Burke from our lab and Winer, Choukér & Crucian
Dan and Shawn Winer retweeted
It is my pleasure to share this in-depth investigation of the gut-brain axis. Hope you will enjoy this humble exploration of new hypotheses--a process I truly enjoyed.
Is brain/gut axis a superhighway for immune response to #Alzheimers? Study @CellReports shows immune cells use that route in mouse models. Feeding animals a high fiber diet reduced AD-related frailty. Congrats @Winer_Imm_Lab @pmakhijani16 @JKAndersenBuck
buckinstitute.org/news/the-g…
Dan and Shawn Winer retweeted
Is brain/gut axis a superhighway for immune response to #Alzheimers? Study @CellReports shows immune cells use that route in mouse models. Feeding animals a high fiber diet reduced AD-related frailty. Congrats @Winer_Imm_Lab @pmakhijani16 @JKAndersenBuck
buckinstitute.org/news/the-g…
Dan and Shawn Winer retweeted
📢New Recommended Reading📖
Substrate stiffness dictates unique doxorubicin-induced senescence-associated secretory phenotypes and transcriptomic signatures in human pulmonary fibroblasts Huixun Du & Daniel A. Winer (@Winer_Imm_Lab) et al.
link.springer.com/article/10…
#tissuestiffness #doxorubicin #transcriptomics #senescentcells #senescenceassociatedsecretoryphenotype
Many age-related diseases involve fibrosis. Study in @GeroScienceAGE shows mechanical forces shape #cellularsenescence and related secretory phenotypes. Researchers in Winer lab ID’d unique high-stiffness-driven secretory protein profiles
link.springer.com/article/10…
doi.org/10.1186/s12979-024-0… Great review on the role of antibodies in obesity and aging pathology.
Substrate Stiffness Dictates Unique Doxorubicin-induced Senescence-associated Secretory Phenotypes and Transcriptomic Signatures in Human Pulmonary Fibroblasts biorxiv.org/content/10.1101/…
Dan and Shawn Winer retweeted
The inflammaging clock strikes IL-11! @ImmunityCP @Winer_Imm_Lab
cell.com/immunity/fulltext/S…
Spotlight on @Nature
nature.com/articles/s41586-0…
The inflammaging clock strikes IL-11!: Immunity cell.com/immunity/fulltext/S…
Dan and Shawn Winer retweeted
This is our first major paper of the lab showing early life modulation of T1D development, linked to maternal IgA deficiency. Super proud of the work twitterless Erinnand Luisa have done!
Maternal humoral factors modulate offspring gut immune homeostasis to mitigate diabetes development @SueYTsai1
doi.org/10.1101/2024.08.28.6…
Dan and Shawn Winer retweeted
Papers from our Space Omics and Medical Atlas (SOMA) package, built upon the extraordinary data from the @inspiration4x mission with @SpaceX are now coming online. With more civilian crews going to space, this is truly the opening of the Second Space Age: nature.com/articles/s41586-0…
