@YYexin
Joined July 2015
  • Tweets24
  • Following89
  • Followers104
1Media
Happy to share our latest work by @YYexin et al. on antibody-mediated control of endogenous retroviruses in mice. In the process, we found “natural antibodies” with broad reactivity against enveloped viruses. Here is how “panviral” antibodies work 🧵(1/) science.org/doi/10.1126/scii…

A B cell screen against endogenous retroviruses identifies glycan-reactive IgM that recognizes a...

Profiling of ERV-reactive B-1 cells in mice reveals natural antibodies against terminal N-acetylglucosamine on multiple viral envelope proteins.

science.org
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This incredible discovery of natural antibody recognition of viral gycans by @YYexin is the result of her meticulousness, creativity, and perseverance. So satisfying and inspiring to watch this story unfold and take so many unexpected turns during my PhD. Congratulations to all!!
Prof. Akiko Iwasaki
@VirusesImmunity8 Nov 2024
Happy to share our latest work by @YYexin et al. on antibody-mediated control of endogenous retroviruses in mice. In the process, we found “natural antibodies” with broad reactivity against enveloped viruses. Here is how “panviral” antibodies work 🧵(1/) science.org/doi/10.1126/scii…

A B cell screen against endogenous retroviruses identifies glycan-reactive IgM that recognizes a...

Profiling of ERV-reactive B-1 cells in mice reveals natural antibodies against terminal N-acetylglucosamine on multiple viral envelope proteins.

science.org
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Absolutely fantastic thesis defense being delivered by soon to be doctor @tianyangmao, spanning RIG-I antiviral approaches to #PrimeandSpike nasal vaccines 🤩 @YaleIBIO @YaleMed
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In this study, @MiyuMoriyama et al investigate how well SARS-CoV-2 variants of concern (VOC) suppress MHC I needed for recognition by cytotoxic T cells. This question is important to understand how well the virus limits CD8 killing 🧵(1/) @biorxivpreprint biorxiv.org/content/10.1101/…
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Our new study by @JieunOh9 @ericsongg @MiyuMoriyama et al shows that immune priming via intranasal route provides superior protection against heterologous respiratory virus challenge. The key is in inducing local secretory IgA with broader coverage. (1/) science.org/doi/10.1126/scii…

Intranasal priming induces local lung-resident B cell populations that secrete protective mucosal...

A heterogeneous population of cells secreting mucosal IgA confers protection against influenza virus infection.

science.org
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Today is #WorldAidsDay2021 Sharing our new review on "Impact of Chronic HIV Infection on SARS-CoV-2 Infection, COVID-19 Disease and Vaccines” by @YYexin. A short thread (1/) link.springer.com/article/10…

Impact of Chronic HIV Infection on SARS-CoV-2 Infection, COVID-19 Disease and Vaccines

Current HIV/AIDS Reports - The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has developed into a global pandemic that affect the health of hundreds of millions worldwide. In...

link.springer.com
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Yexin Yang retweeted
Can Cui@CanCuiMDPhD30 Nov 2021
HELLO, world! Excited to share our work online today @CellCellPress with @Joshilabyale and Dr. Joe Craft. Grateful to all the collaborators that made this study possible!
Nik Joshi@Joshilabyale30 Nov 2021
HELLO! Our latest story is now out online @CellCellPress showing tumor neoantigens with B cell-epitopes promote B cell-TFH interactions and IL-21 that drives CD8 T cell effector function in tumors. Congrats @cancuiyale, Joe Craft, and our co-authors! cell.com/cell/fulltext/S0092…

Neoantigen-driven B cell and CD4 T follicular helper cell collaboration promotes anti-tumor CD8...

B cells promote the differentiation of tumor-specific CD4 T follicular helper cells in a neoantigen-dependent manner, which in turn enhance CD8 T cell effector functions by producing IL-21 and drive...

cell.com
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Thinking of all the women left anxious and confused about the vaccine, who deserve so much more from us. And eternally grateful to the two women in particular @randihepstein and @VirusesImmunity who believed in this message and in me. Mentorship matters. nytimes.com/2021/01/26/opini…

Opinion | The False Rumors About Vaccines That Are Scaring Women (Published 2021)

We don’t know everything about Covid-19, but getting immunized is still the best way to protect your health.

nytimes.com
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And we’re off to a fantastic start to the #IwasakiLabReunion Symposium! In the first session @EllenFoxman discussing viral interference during respiratory infections and @JennyLund15 on the role of Tregs during viral infections. 🙌🔥
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AND IT’S LIVE: our latest pre-print, on the use of saliva as a diagnostic sample for #SARSCoV2 testing, from the massive team effort on Yale’s #COVID19 response @YaleSPH @YaleEMD @YaleMed @VirusesImmunity @YaleGH @Yale @YNHH disq.us/t/3o287u4

Saliva is more sensitive for SARS-CoV-2 detection in COVID-19 patients than nasopharyngeal swabs

Rapid and accurate SARS-CoV-2 diagnostic testing is essential for controlling the ongoing COVID-19 pandemic. The current gold standard for COVID-19 diagnosis is real-time RT-PCR detection of SARS-C...

medrxiv.org
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New Comment article from @VirusesImmunity and Yexin Yang on the potential danger of suboptimal antibody responses in COVID-19 nature.com/articles/s41577-0…
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This is a cautionary tale of how anti-Spike antibody may make COVID disease worse. In this study, the authors show that anti-Spike IgG made SARS-CoV disease worse by switching macrophage from wound-healing to proinflammatory phenotype. A thread (1/n) insight.jci.org/articles/vie…
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Let's dispel the notion that "novel coronavirus is just like the flu". Sharing this striking comparison of #Flu, #COVID19, #SARS and #MERS made by @BioRender. #COVID19 is 30x more deadly and almost 2x more contagious than the flu. We have no existing immunity to COVID19.
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Researchers rush to test #coronavirus vaccine in people without knowing how well it works in animals. A great summary and discussion by @EricBoodman 👇🏽 #COVID19 #Vaccines #Immunology statnews.com/2020/03/11/rese… via @statnews

Researchers rush to test coronavirus vaccine in people without knowing how well it works in animals

Researchers aren’t waiting to see how well an experimental #Covid19 #coronavirus vaccine prevents infection in animals before trying it in people, breaking from the usual protocol.

statnews.com
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New #SARSCoV2 #COVID19 paper just accepted at Cell! Cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically-proven protease inhibitor. #2019nCoV cell.com/2019-nCOV
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The first @VirusesImmunity lab brain tumor paper is out today! nature.com/articles/s41586-0…. We began the project wanting to understand the role of meningeal lymphatics in brain tumor. To our surprise, when we expanded the lymphatics with VEGF-C, mice could no longer grow tumors!
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Yexin Yang retweeted
Immunity@ImmunityCP14 Feb 2019
Meet the @VirusesImmunity lab from @YaleIBIO @YaleMed They're interested in Cellular trafficking; Host-pathogen interactions; Immune memory; Innate immunity; Mucosal immunology; #Neuroimmunology; #Vaccines; Viral immunity #ImmunityCommunity cell.com/immunity/community
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Sci-art is always a lot of fun!
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So grateful to find out about my student giving a great talk through Twitter! Of course I am not at all surprised - @ericsongg is a rock star! #GRC_neuroimmune. @YaleIBIO
Michelle Monje 🟦
@michelle_monje14 Jan 2019
Wonderful talk at the #GRC_neuroimmune by graduate student Eric Song from the @VirusesImmunity Lab!
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Just one week until the Yale iBio graduate student symposium. An amazing lineup of speakers.
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