@ZX_Liang

Nanyang Technological University, School of Biological Sciences, Singapore

 Singapore
Joined November 2017
  • Tweets49
  • Following86
  • Followers69
4Media
Genome editing of phylogenetically distinct bacteria using cross-species retron-mediated recombineering. nature.com/articles/s41587-0…

Genome editing of phylogenetically distinct bacteria using cross-species retron-mediated recombin...

Nature Biotechnology - Retron-based systems for genome editing are functional across bacterial species.

nature.com
1
3
26
2,263
Harnessing biosynthetic logic for next-generation ADC payloads - now published in Chemical Society Reviews pubs.rsc.org/en/content/arti…@

Harnessing biosynthetic logic for next-generation ADC payloads

Antibody–drug conjugates (ADCs) have revolutionized oncology by linking the precise targeting of monoclonal antibodies with the ultrapotent activity of sma

pubs.rsc.org
2
54
We couldn’t have discovered those interesting antimalarial compounds without the help from our wonderful collaborators. Genome‐Guided Discovery of Antimalarial 4‐Amino‐2,4‐Pentadienoate‐Containing Cyclolipodepsipeptides - Candra - Angew Chem Intl Ed - onlinelibrary.wiley.com/doi/…

Genome‐Guided Discovery of Antimalarial 4‐Amino‐2,4‐Pentadienoate‐Containing Cyclolipodepsipeptides

Halogenated and glycosylated 4-amino-2,4-pentadienoate-containing cyclolipodepsipeptides (APD-CLDs) exhibit potent antiplasmodial activity (IC50 = 25–161 nM) against drug-sensitive and resistant...

onlinelibrary.wiley.com
1
1
5
153
Zhao-Xun Liang retweeted
Northwestern@NorthwesternU14 Oct 2025
What it's all about. 💜🥹 Prof. Joel Mokyr, winner of the @NobelPrize in Economic Sciences, shares a lovely message from a former student.
18
481
97
2,058
331,596
Functional Characterization of a Diazo-Forming Enzyme in Meroterpenoid Biosynthesis chemistry-europe.onlinelibra…

Functional Characterization of a Diazo‐Forming Enzyme in Meroterpenoid Biosynthesis

A diazo-forming enzyme (stFur5) facilitates deamination in the biosynthesis of furaquinocins and other polyketide-derived meroterpenoids.

chemistry-europe.onlinelibrary.wiley.com
1
2
76
Career opportunity in Singapore
1
99
Big Thanks to our collaborators @pchaiyen @guanglei_Ma @HoaUSD12345, Profs Li Jian, and Gao YG An Enzymatic Oxidation Cascade Converts δ-Thiolactone Anthracene to Anthraquinone in the Biosynthesis of Anthraquinone-Fused Enediynes | JACS Au pubs.acs.org/doi/abs/10.1021…
1
4
1
16
1,293
Streptomyces sungeiensis SD3 as a Microbial Chassis for the Heterologous Production of Secondary Metabolites | ACS Synthetic Biology pubs.acs.org/doi/10.1021/acs… A useful Streptomyces strain from the Johor Strait @zjlow @guanglei_Ma @

Streptomyces sungeiensis SD3 as a Microbial Chassis for the Heterologous Production of Secondary...

Abstract. We present the newly isolated Streptomyces sungeiensis SD3 strain as a promising microbial chassis for heterologous production of secondary metab

pubs.acs.org
1
3
223
Happy to share our review of cyclic-di-AMP signalling in lactic acid bacteria as part of the @LABsymposiumorg special edition in @FEMSmicro Thanks to @HuongPham2021 @Es_Marcellin @ZX_Liang & Yuwei for your contributions and many years of collaboration academic.oup.com/femsre/arti…
3
11
1
31
4,770
“resistant #pseudomonas was especially difficult to eradicate” 😱 nytimes.com/2023/04/03/healt…

Drug-Resistant Bacteria Tied to Eyedrops Can Spread Person to Person (Gift Article)

The C.D.C. traced deaths and cases of blindness to products imported from India. The agency said it was concerned that the bacteria could gain a foothold in the U.S.

nytimes.com
1
5
1
6
2,117
Today we're making RF Diffusion, our guided diffusion model for protein design with potential applications in medicine, vaccines & advanced materials, free to use. The software has proven much faster and more capable than prior protein design tools. bakerlab.org/2023/03/30/rf-d…
6
290
67
930
393,255
Enaminone formation drives the coupling of biosynthetic pathways to generate cyclic lipopeptides chemistry-europe.onlinelibra… @hart

Enaminone Formation Drives the Coupling of Biosynthetic Pathways to Generate Cyclic Lipopeptides

A group of enaminone-containing cyclic lipopeptides were surprisingly found to be formed in microbial cells. The enaminone moiety results from the coupling of two biosynthetic pathways via amine-al...

chemistry-europe.onlinelibrary.wiley.com
2
#Biosynthesis of Tasikamides via Pathway Coupling & Diazonium-Mediated Hydrazone Formation by @guanglei_Ma, H. Candra, L. Mei Pang, J. Xiong, Y. Ding, H. Thi Tran, @ZhenjieLow, H. Ye, M. Liu, J. Zheng, M. Fang, @embb_ntu, @ZX_Liang in @J_A_C_S pubs.acs.org/doi/10.1021/jac…
1
12
2
66
To our surprise, we found hydrazone can be formed via diazonium-mediated Japp-Klingemann reaction in microbial cells, thanks to the excellent work of @guanglei_Ma, Hart, @hoatran227, @zjlow, Pang LM... and our collaborators Profs Cao Bin and Fang Mingliang
Top Science
@isciverse22 Jan 2022
Online NOW | @J_A_C_S #Biosynthesis of #Tasikamides via Pathway Coupling and Diazonium-Mediated #Hydrazone Formation. @isciverse @AmerChemSociety pubs.acs.org/doi/10.1021/jac…
5
1
13
Zhao-Xun Liang retweeted
Mitch Guttman@mitchguttman4 Nov 2021
What drives organization of RNA, DNA, and proteins in the nucleus? In our new paper out @CellCellPress, we show that non-coding RNAs play a central role through a unique RNA-based mechanism. authors.elsevier.com/c/1e132…
19
343
35
1,139
A proof of concept for c-di-GMP phosphodiesterase-activating drugs administered in combination with antibiotics as a viable treatment strategy for otherwise recalcitrant infections nature.com/articles/s41522-0…
2
11
Zhao-Xun Liang retweeted
Gordan Lauc@GordanLauc30 Jul 2021
Understanding biology, and host/pathogen interactions in particular (including #SARSCoV2) without looking at glycan part of proteins is simply not possible. You do not have to take my word for it, check that latest issue of Nature instead... nature.com/articles/d41586-0…
1
20
3
102
Zhao-Xun Liang retweeted
UniProt@uniprot22 Jul 2021
A historic moment in the world of molecular structural research. #AlphaFold structure predictions for 22 species made freely available by @deepmind, access through @uniprot and @PDBeurope. Learn more at insideuniprot.blogspot.com/
13
327
47
874
Very pleased to see that we are ranked 3⃣3⃣ in the world in Biological Sciences by QS @worlduniranking. Awesome work from #ntusbs staff and students. #ntusbs community should be proud about this impressive rise over the years 🚀
4
1
13
Pathway Retrofitting Yields Insights into the Biosynthesis of Anthraquinone-Fused Enediynes pubs.acs.org/doi/10.1021/jac… @hoatran227 @zjlow

Pathway Retrofitting Yields Insights into the Biosynthesis of Anthraquinone-Fused Enediynes

Abstract. Anthraquinone-fused enediynes (AQEs) are renowned for their distinctive molecular architecture, reactive enediyne warhead, and potent anticancer

pubs.acs.org
1
3
5
Load more