@adamdesmith

Assistant Professor @KeckMedUSC Center for Genetic Epidemiology. Researching the causes of childhood cancer. https://xitter.cf/t.co/5hU2I4xe3S

 Los Angeles, CA
Joined April 2011
  • Tweets745
  • Following537
  • Followers332
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New year, new opportunities! Looking for a postdoc to join our group @USC @usc_cge, to work on exciting projects related to understanding the origins of childhood leukemia and disparities in leukemia risk. Info here: usccareers.usc.edu/job/los-a… @uscpphs #epitwitter 🧬🩸🌞
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🧵 Thrilled to share our latest in @Nature! We’ve mapped fetal blood development in Down syndrome (DS) using single-cell multi-omics, studying why children with DS face a 150-fold higher leukemia risk and blood abnormalities at birth. nature.com/articles/s41586-0…

Single-cell multi-omics map of human fetal blood in Down syndrome

Nature - Using single-cell and multi-omics data of fetal blood, a high-resolution molecular map of dysregulated haematopoiesis in Down syndrome is provided.

nature.com
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Glad to have presented my research at the @AACR 's disparities conference. We leveraged the NAACCRegistry to see if Hispanic/Latinos have higher risk of leukemia across its molecular subtypes! @adamdesmith
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🗣️ Breaking ground in pediatric cancer research! This #NationalCancerResearchMonth, we're proud to partner with @adamdesmith, PhD from @KeckMedicineUSC, to uncover the roots of acute lymphoblastic leukemia (ALL) in children. Learn more about his efforts 👉 bit.ly/4ezRtOU
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So proud that this work is now published @AJHGNews. It was truly an effort of a team of undergrad students (at the time), led by @itscahoon. It was also a project used to introduce new grad students or others just getting into genomic analysis - the team effort really worked out!
AJHG@AJHGNews10 Apr 2024
📢New from @itscahoon @CharlestonCWKC & co 📰Imputation accuracy across global human populations cell.com/ajhg/abstract/S0002…
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Adam de Smith retweeted
Jun Yang@Junjyang8 Apr 2024
The stars are aligning (literally) for our paper to come out today 😂🌞 @jiyang_yu @StJudeResearch
St. Jude Research
@StJudeResearch8 Apr 2024
By characterizing B-cells’ developmental stages, St. Jude scientists designed and tested a drug combination to effectively treat resistant B-cell leukemia and reduce side effects. Learn more about the research by @Jiyang_Yu and @JunJYang. bit.ly/4avBOh1
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Thrilled to see our work on genetic prediction of immune checkpoint inhibitor-mediated colitis published in @NatureComms @ziv_elad @rohit_thum @MelindaAldrich @Linda_Kachuri nature.com/articles/s41467-0…

Polygenic risk score for ulcerative colitis predicts immune checkpoint inhibitor-mediated colitis

Nature Communications - Colitis is one of the most common immune-related adverse events in patients with cancer treated with immune checkpoint inhibitors. Here the authors show that a polygenic...

nature.com
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Excited to see our latest work published in @CellGenomics today! We found that genetic variation at IKZF1 contributes to the increased risk of ALL in Hispanic/Latino children in the US, and shed light on functional mechanisms underlying IKZF1 risk alleles cell.com/cell-genomics/fullt…

A noncoding regulatory variant in IKZF1 increases acute lymphoblastic leukemia risk in Hispanic/L...

Genetic fine-mapping across the IKZF1 gene revealed a variant associated with childhood ALL that contributes to the increased risk of this disease in Hispanic/Latino individuals. The ALL risk allele...

cell.com
Vijay Sankaran
@bloodgenes26 Mar 2024
Why do Latino children have the highest risk for childhood leukemia in the US? We identify one cause for this in a paper out in @CellGenomics today, led by @adamdesmith, @LWahlster, @SoYoungJeon_Eli, @fulong_yu, @CharlestonCWKC, & colleagues: cell.com/cell-genomics/fullt…
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This was a really fun project to work on! An awesome collaborative effort with @bloodgenes, @CharlestonCWKC, @LWahlster, @SoYoungJeon_Eli, @fulong_yu, @Linda_Kachuri et al!
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In lieu of a long thread, here's a short video explainer... xitter.cf/uscnorris/status/17727…
USC Norris Comprehensive Cancer Center@uscnorris26 Mar 2024
Published in @CellGenomics, USC researchers find genetic variant contributing to disparities in childhood #leukemia risk. This work was done in collaboration with @harvardmed and @DFBC_PedCare. Read more here: keck.usc.edu/news/usc-resear…
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Published in @CellGenomics, USC researchers find genetic variant contributing to disparities in childhood #leukemia risk. This work was done in collaboration with @harvardmed and @DFBC_PedCare. Read more here: keck.usc.edu/news/usc-resear…
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✨Congratulations to our faculty member Marlena Fejzo, PhD, (@DrFejzo) who has been named one of @TIME magazine's 2024 'Women of the Year.' Join us in celebrating her impactful research and this exemplary recognition.
Keck School of Medicine of USC@KECKSchool_USC21 Feb 2024
Geneticist Marlena Fejzo, PhD, has been named one of @Time magazine’s 2024 ‘Women of the Year.’ ⭐️ She was chosen for her recent study showing a hormone produced by the fetus triggers nausea and vomiting during #pregnancy. keck.usc.edu/news/usc-geneti… Photo: @gandolphoto
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Geneticist Marlena Fejzo, PhD, has been named one of @Time magazine’s 2024 ‘Women of the Year.’ ⭐️ She was chosen for her recent study showing a hormone produced by the fetus triggers nausea and vomiting during #pregnancy. keck.usc.edu/news/usc-geneti… Photo: @gandolphoto
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🎙SEASON 3: We're kicking off the return of our podcast with @DrFejzo, PhD, who discusses her recent study on extreme morning sickness. Learn more about the clinical implications of her findings & why she decided to study this area of research. 📷Listen📷keck.usc.edu/pphs/podcast/
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Adam de Smith retweeted
Vijay Sankaran
@bloodgenes12 Jan 2024
Wonderful to have our paper, "Inherited blood cancer predisposition through altered transcription elongation", published (open access) in @CellCellPress today! cell.com/cell/fulltext/S0092… 🧵 (1/n)
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Feel free to DM or email me (address in link above) to learn more about the role. Our lab is also a part of the USC Center for Genetic Epidemiology: keck2.usc.edu/genetic-epidem…
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“Backtracking to the Future” ! Our new article in Leukemia describes the prenatal origins of childhood leukemia, and what we hope to learn by studying patient cord blood samples in the ReCord study (record.umn.edu) rdcu.be/dt7ej
andi roy@andiroy21 Dec 2023
I really enjoyed writing this perspective piece with @adamdesmith and other collaborators, out now in @LeukemiaJnl . (If you want to know more about the ReCord study, or recruit patients to it, details are here: record.umn.edu/ ) rdcu.be/dt7ej
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🎙️EP 15: Pursuing Prevention of Acute Lymphoblastic Leukemia (ALL) with @adamdesmith, PhD. His research is focused on trying to understand causes of ALL, the most common childhood #cancer, by identifying genetic risk factors and environmental exposures. ➡️pphs.usc.edu/podcast/
EP 15: Pursuing Prevention of Acute Lymphoblastic Leukemia (ALL) with @adamdesmith, PhD.

ALT EP 15: Pursuing Prevention of Acute Lymphoblastic Leukemia (ALL) with @adamdesmith, PhD.

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Adam de Smith retweeted
Julia Mouat@JuliaMouat9 Oct 2023
I’m excited to share my recent publication where we identified a DNA methylation signature of congenital heart defects in newborns with Down syndrome! Check it out: humgenomics.biomedcentral.co…

Epigenomic signature of major congenital heart defects in newborns with Down syndrome

Human Genomics - Congenital heart defects (CHDs) affect approximately half of individuals with Down syndrome (DS), but the molecular reasons for incomplete penetrance are unknown. Previous studies...

link.springer.com
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🔬 Excited to share my second paper from PhD published in HGG Advances: "Evaluating Genomic #Polygenic Risk Scores for Childhood Acute Lymphoblastic #Leukemia in #Latinos" 🧬
Human Genetics and Genomics Advances@HGGAdvances14 Sep 2023
💫New @HGGAdvances 💫 📰Evaluating Genomic #Polygenic Risk Scores for Childhood Acute Lymphoblastic #Leukemia in Latinos 🧑‍🤝‍🧑@CharlestonCWKC @adamdesmith & colleagues #PRS #OA 👉bit.ly/3PFh7ag
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