Allison Chang (@aebchang) header
Allison Chang (@aebchang) profile picture

Neuroscientist ➡️ Thoracic Medical Oncologist specializing in #earlydetection #AI #ML @mghcancercenter @harvard Cat mom. Human mom. Wife. Opinions mine.

Boston, MA
Joined January 2010
Photo by Allison Chang (@aebchang)Photo by Allison Chang (@aebchang)Photo by Allison Chang (@aebchang)Photo by Allison Chang (@aebchang)Photo by Allison Chang (@aebchang)Photo by Allison Chang (@aebchang)Photo by Allison Chang (@aebchang)Photo by Allison Chang (@aebchang)Photo by Allison Chang (@aebchang)Photo by Allison Chang (@aebchang)
RT @AmLungCSI: Join us for the Stronger Together Health Fair in Boston on October 31st! Hosted by GEDI and ALCSI, this free community even…
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Allison Chang retweeted
Replying to @unusual_whales
I worry this makes things really hard for extremely attractive people who just want to seduce an OpenAI or Anthropic employee for their money
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Following Pope Leo XIV’s diagnosis and lung cancer surgery, ALCSI founder and thoracic surgeon Dr. Jeff Yang (@ChiFuJeffYang) spoke with The New York Times (@nytimes) and several TV news channels about the lifesaving benefits of lung cancer screening and the excellent outcomes that are possible when lung cancer is found early. We wish Pope Leo XIV a smooth and speedy recovery 💕 nytimes.com/2026/10/14/well/…
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ALCSI’s Deepti Srinivasan (@DeeptiSrini) gave a terrific presentation at the World Conference on Lung Cancer (#WCLC26). She presented the first national estimate of lung cancer incidence among people who have never smoked in the United States, finding that nearly 30,000 people who have never smoked are diagnosed with lung cancer each year. Our team also found that 17% of women, 77% of U.S Asian women, and 58% of patients under the age of 40 had never smoked. This work highlights the urgent need to develop strategies for early detection in people who have never smoked.
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Allison Chang retweeted
‼️ SAVE THIS TWEET if you see patients with EGFR exon 20 NSCLC ‼️ Beautiful discussion by @LudaBazhenovaMD here at #WCLC26 As new options emerge for our patients, how do we choose?
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Allison Chang retweeted
Dr. @alexdrilon at #WCLC26 presents 1L cohort of ARROS-1 trial of zidesamtinib in pts with ROS1 NSCLC. What a waterfall plot. RR 94% with 15% CR. mPFS not reached, PFS at 6m was 96% and at 12m was 90%. Intracranial RR 100%. In 78 pts who did not have brain metastases at baseline, no CNS events occurred to date. These are fantastic outcomes.
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Allison Chang retweeted
Dr. Ross Camidge honored with the Paul Bunn Jr. Scientific Award - one of the brightest minds in thoracic medical oncology, a true pioneer, and a role model to so many. #WCLC26
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Replying to @StephenVLiu
@StephenVLiu - the actual pCR rate is 34% based on the report. They left out 11 patients from the denominator. It is misleading…
Replying to @StephenVLiu
#ASCO26 With neoadjuvant lorlatinib, pCR 47% and MPR 81%. Amazing. RR 84% and 1y EFS 97%. Down staging of nodes in 90%. Very reassuring and consistency safety results. Phenomenal clinical results.
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Allison Chang retweeted
Really impactful talk by Alex Potter (@alexandra_p_24) on long-term (5+ years) quality of life after #LungCancer surgery. Data from the Boston Lung Cancer Study show survivors have high quality of life, comparable to the U.S. general population. Early detection matters—it can help lead to good long-term outcomes for patients!! #AATS2026
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Allison Chang retweeted
maybe this is not yet clear, so let me state it plainly: as of right now Anthropic, and really a small number of individuals at Anthropic, has the capacity to directly attack and cause major damage to the United States Government, China, and generally global superpowers. government agencies like the NSA do not have internal models or defense capabilities that outclass frontier models. if they chose to do so, they could likely exfiltrate top secret information from government systems, gain control over critical infrastructure including military infrastructure, sabotage or modify communications between members of government at the highest level, and potentially carry on activities for some time without detection. the thing about having access to a huge number of zerodays your adversaries don't know about is it gives you a massive asymmetric advantage. they did not exploit this to gain power or destabilize the world order. they publicly released the information that they had these capabilities and worked to mitigate these flaws. you should be grateful american frontier labs have proven themselves remarkably trustworthy and concerned with the public good. but it's critical you understand we are in a new regime. private entities now have power that directly rivals and impacts the government's monopoly on influence and violence. and anthropic is certainly not the only one, there's little chance OpenAI's internal models are far behind. this trend will accelerate on virtually every dimension, not slow down. my prediction for how it plays out is the relatively imminent seizure and nationalization of labs by the US government, sometime over the next two years. it's very tough for me to see how they accept the existence of this kind of threat. but this adds a whole new class of governance issues, as then we've handed these extremely wide-reaching capabilities from private entities to public ones.
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Absolutely inspirational Patterson plenary lecture on #lungcancerscreening at AATS #ITSOS2025 by @DouglasEWood1!! Dr. Wood has been a relentless advocate and was instrumental in getting #lungcancerscreening covered by health insurance in the US. He also emphasized the need to simplify lung cancer screening guidelines: get rid of 15 years since quit, and use smoking duration instead of pack years to guide eligibility criteria (go w/ #Pottercriteria)
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So impressed with @MaryPasquinelli’s work where she demonstrated that Sybil, an AI algorithm, can accurately predict 6-year #lungcancer risk from one baseline CT scan, in diverse cohorts, with minimal bias!! #WCLC25
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One of the biggest influences on my career is Dr. Ross Camidge - a mentor and friend, an intellectual giant in the field of lung cancer who was diagnosed with this unforgiving disease himself. We are all at risk - and must all work to move the field. news.cuanschutz.edu/cancer-c…
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COMPEL(ing) study at #WCLC25. Limitations noted below, but in EGFR+ NSCLC with NON-CNS progression on 1L osi, CONTINUING osi w/ chemo improved outcomes: ▫️PFS: 8.4 vs 4.4 mo (HR 0.43) ▫️Fewer new brain mets: 10% vs 27% Osi to remain our backbone across lines? #WCLC25 @IASLC
Very intriguing results presented by Dr Pasello from the COMPEL trial of chemo +\_ osi upon progression on osimertinib in pts w advanced EGFR+ NSCLC While study stopped early and not definitive- strong signals of benefit noted, mainly due to clear CNS protective effect How do these results impact practice esp w changes in frontline tx? Well, from here on it should certainly be a No-Brainer to always consider the CNS compartment through lines of therapy for our EGFR-mutated pts #WCLC25 @IASLC
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A labor of love! @MaryPasquinelli masterfully explaining how we implemented Sybil, a machine learning model of lung cancer risk, at @UICancerCenter @UIHealth . Would not be possible without the Sybil implementation consortium. @LeciaSequist @F_Fintelmann_MD @aebchang @reginabard
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E4512: adjuvant crizotinib for resected stage II-III ALK+ NSCLC #DavidGerber. Insightful discussion by @JessicaJLinMD #WCLC25 💠Adjuvant crizotinib did not prolong median DFS 💠Biomarkers still critical for early-stage NSCLC given role of TKIs eg. osi (ADAURA) & alectinib (ALINA)
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Allison Chang retweeted
Outstanding video explaining Sybil, a powerful new AI model built by my mentor @LeciaSequist, @BarzilayRegina, @F_Fintelmann_MD et al that will change how we think about predicting future illness--starting with #lungcancer! #LCSM @MGHCancerCenter @MassGeneralNews @MGHThoracicOnc
As lung cancer rates rise in nonsmokers, a troubling trend for the #1 deadliest cancer, we hope more hospitals will adopt tools like Sybil, an AI model built by #JClinic & @MassGenBrigham researchers that predicts lung cancer risk up to 6 years in advance. youtu.be/xGSiP8i4VbU
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Thank you @ASCO for the opportunity to present our work. Incredibly grateful to @KimmieNgMD and Chen Yuan for their mentorship @DanaFarber
.@sarakcharMD presents intriguing findings on how diet impacts survival in stage III colon cancer patients. The study examines the link between dietary inflammation and outcomes, offering insights into nutrition's role in cancer care. #ASCO25
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Thank you @WSJ for featuring our work! Healthy diet and physical activity are essential parts of colon cancer care and survivorship. Looking forward to presenting the results of our study examining inflammatory diet and colon cancer survival at #ASCO25 today at 4:30 pm in Hall B1
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