Professor, Technion - Israel Institute of Technology @ArielKaplan.bsky.social
Israel
Joined July 2009
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🧵New preprint! How does an elongating RNA polymerase deal with a DNA-bound transcription factor in its path?
We developed a label-free single-molecule assay that detects RNAP arrival by suppression of fluctuations in a partially unzipped DNA fork.
biorxiv.org/cgi/content/shor…
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Ariel Kaplan retweeted
Found in translation: Using single-molecule imaging, we show that ERK signaling controls where protein translation happens during hypertrophic stimulation in #cardiomyocytes —revealing a dynamic, localized response.
Erlich & colleagues uncover a dynamic, location-based control of #protein synthesis in heart cells that drives #cardiac growth. Learn more at ahajrnls.org/3W5JJPG
@itaie21 @KehatLab
Ariel Kaplan retweeted
Ada Yonath obituary: Crystallographer who overcame ‘impossible’ challenge of mapping the ribosome
go.nature.com/4gOtwFr
Postdoc opportunity in our lab!
Use optical tweezers and single-molecule fluorescence to study protein-DNA interactions, transcription and chromatin dynamics.
Azrieli Postdoctoral Fellowship:
azrielifoundation.org/fellow…
[email protected]
Prese share!
#Postdoc #Biophysics
Ariel Kaplan retweeted
Direct visualization of MCM helicase activation and replisome coupling in situ . We used MINFLUX to visualize MCM hexamers in human cells. A wonderful collaboration with Supriya Prasanth in UIUC, Jonas Zähringer, Oraya Zinder biorxiv.org/content/10.64898…
Ariel Kaplan retweeted
Come join our #CDlab!
We have various open positions for PhD students or postdocs, see ceesdekkerlab.nl/come-join-u…
Particularly, I search a PhD student for protein sequencing with nanopores (keywords: nanopores, DNA origami, peptide/protein sequencing)
Apply!
RT=👍
Ariel Kaplan retweeted
After a while not posting, happy to share our latest paper on how the different J-domains interact with the various HSP70s! Proud of Roni and of the outcome🏆 @PNASNews
pnas.org/doi/10.1073/pnas.25…
Ariel Kaplan retweeted
How does RNAP get past a TF bound in its path? Not by merely pushing it off. We think it destabilizes the TF in a distance-dependent manner. The barrier is set by the TF's res. time, which may be tuned by gene-body CpG methylation. Congrats to @Noamnago @akaplanz, and the team!
🧵New preprint! How does an elongating RNA polymerase deal with a DNA-bound transcription factor in its path?
We developed a label-free single-molecule assay that detects RNAP arrival by suppression of fluctuations in a partially unzipped DNA fork.
biorxiv.org/cgi/content/shor…
1/
Ariel Kaplan retweeted
New Online! Exchange dynamics and kinetic control of gene regulation complexes dlvr.it/TTn7vb
Finally, CpG methylation shortened Egr-1 residence time and almost eliminated the transcription delay.
Since DNA methylation is widespread within mammalian gene bodies, this suggests a potential mechanism for tuning the kinetic barriers encountered by an elongating RNAP.
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Summary: TF barriers are dynamic, arising from coupled RNAP–TF kinetics, and widespread gene-body DNA methylation may tune these barriers.
Kudos to @Noamnago and @nucleosomezky who led the work, and thanks to @NirStrugo, @Hadeel_Khamis8, Carmit Burstein and @LabPMelamed
Ariel Kaplan retweeted
Congratulations to Technion Prof. Debbie Lindell on being elected to the European Molecular Biology Organization (@EMBO)! Her pioneering research on viruses and marine microorganisms is advancing our understanding of ocean ecosystems and life on Earth. 🌊🔬
#EMBO #LifeSciences #MarineScience #Microbiology
technion.ac.il/en/blog/artic…
Ariel Kaplan retweeted
Technion researchers have developed a first-of-its-kind dual-targeting PROTAC that selectively destroys aggressive, treatment-resistant cancer cells while largely sparing healthy cells. A promising step toward next-generation precision cancer therapies.
🔗 technion.ac.il/en/blog/artic…
#CancerResearch #PrecisionMedicine #Technion #Oncology #PROTAC
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