PhD from @Caltech in synthetic biology, Elowitz Lab
Los Angeles, CA
Joined November 2018
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- Following1K
- Followers304
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Andrew Lu retweeted
Sahil, thanks for sharing this. I'm excited for this to reach as many potential people as possible, and all the ideas are free, no paywall of any kind..
Bill Gross has started more than 175 companies.
His newest one gives startup ideas away. Idealab.ai launched with 1.2 million of them, free and searchable.
The AI scans 17M+ sources for real-world problems and turns them into businesses you could build. Labs lets you test an idea first, and the goal is to match $100M in funding.
Cloudflare and Mercury are on as partners.
Would you build a company off an AI's idea?
Andrew Lu retweeted
Our paper is finally out in Cell! Years of work on one of biology's most beautiful tissue clocks, and finding an intrinsic oscillator that helps organize tissue dynamics. From my PhD work at @LongCai_Lab, with Shosei Yoshida and Ben Simons!
🧵(1/10)
cell.com/cell/fulltext/S0092…
Andrew Lu retweeted
Had fun thinking about this. Check out @FelixHorns lab, he’s the best to work with!
Our new Comment is out today in @natrevbioeng. mRNA could treat many more diseases than it currently does, but we don’t have a way to get it to most of the cells where it’s needed. We explain why a cell will be the next transformative delivery vehicle⬇️
Andrew Lu retweeted
We’re thrilled to introduce the second cohort of FutureHouse AI-for-Science Independent Postdoctoral Fellows: five exceptional scientists pursuing bold research at the intersection of AI and science.
Please join us in welcoming:
Hanqing Liu, Alexander Starr, Jeremy Koob, Soojung Yang, and Andrew Lu
Starting in September, these Fellows will leverage cutting-edge AI Scientists to advance their projects in genomics, neuroscience, protein design, biophysics, and cancer therapeutics.
This year, we're also proud to partner with @KavliFoundation, who is sponsoring one of our Fellows.
We’re excited to support this cohort as they pursue ambitious, independent research and help expand what AI can make possible in science.
Learn more about the 2026 Fellows and the Fellowship program here: futurehouse.org/fellowship-p…
#FutureHouse #AiforScience
Andrew Lu retweeted
Check out our new perspective "Illuminating the universe of enzyme catalysis in the era of artificial intelligence" now out in @CellSystemsCP !
We discuss a vision and path forward for genetically encoding almost all chemistry, powered by new AI tools:
authors.elsevier.com/c/1lg4h…
Check out what I’ve been up to for the past four years at Caltech! Exciting road ahead for therapeutic circuits.
Synthetic biology could enable new types of programmable therapeutics. Our new preprint introduces synthetic protein circuits that selectively trigger cell death in Ras-mutant cancer cells, with interesting advantages compared to existing approaches.
biorxiv.org/content/10.1101/…
Andrew Lu retweeted
I'm excited to share our new preprint "Steering Generative Models with Experimental Data for Protein Fitness Optimization" (🧵1/5)!
Paper: arxiv.org/abs/2505.15093
Code: github.com/jsunn-y/SGPO
Andrew Lu retweeted
Delighted our latest finding! We discovered that abstract representations emerge in the human hippocampus when learning to perform inference. This change in neural geometry is due to disentanglement of discovered latent and observable variables. @Nature nature.com/articles/s41586-0…
Andrew Lu retweeted
Our work describing extensive gene divergence on laboratory timescales with upgraded OrthoRep systems is now out in @ScienceMagazine here - science.org/doi/10.1126/scie…. X thread describing the preprint is quoted below. Congratulations to @rix_gordon and team!
In this work, we bring OrthoRep’s mutation rate up to 10^-4 substitutions per base, allowing us to durably hypermutate and evolve chosen genes in vivo at 1-million times the genomic mutation rate of the host yeast cell. What does this afford? biorxiv.org/content/10.1101/…
Andrew Lu retweeted
Our paper on lineage motifs is now online at @Dev_Cell 😀 We hope that this approach will be widely useful for anyone interested in analyzing tree-type datasets!
Online now: Lineage motifs as developmental modules for control of cell type proportions dlvr.it/T2lKM6
Andrew Lu retweeted
Thompson et al. demonstrate improved power in transcriptome-wide association studies with a method splitting genetic effects into context-shared and context-specific terms.
@brunilda_balliu @andreww_lu @yimmieg @MGraceGordon
nature.com/articles/s41467-0…
Andrew Lu retweeted
Can proteins perform neural network computation? Together with James Linton, @RonZhu2015, and @ElowitzLab, we had a lot of fun creating the "perceptein" -- a protein circuit that performs winner-take-all neural network computation in mammalian cells: biorxiv.org/content/10.1101/… (1/4)
Andrew Lu retweeted
In 2018, we developed mux-seq and demuxlet to enable population-scale single-cell sequencing. Today, excited to share our paper in @ScienceMagazine where we deployed mux-seq to profile 1.2M immune cells from 162 lupus patients and 99 healthy controls: science.org/doi/full/10.1126…. 1/n
Andrew Lu retweeted
Online now! In a feat of synthetic engineering, mammalian cells were engineered with a plant hormone system and robust synthetic signaling pathways that allow for population sensing and control
#syntheticbiology #ScienceTwitter
bit.ly/3vtslVO
Andrew Lu retweeted
I'm excited to announce I'm leaving Caltech for my dream of building a synthetic biology company. Along with a great group of people, including the brilliant @ElowitzLab, we founded @PrimordiumLabs with the sole purpose of accelerating cutting-edge synthetic biology research. 1/
Andrew Lu retweeted
This illustration by @Wonderstrucksci, inspired by Waddington’s second most famous drawing, shows with remarkable directness how MultiFate’s 3 transcription factors, interacting in combinations, produce a multistable epigenetic landscape.
Andrew Lu retweeted
We found a Christmas themed plasmid in the repository! 🎄 pEF-XMAS-1xStop expresses a Transient Reporter for Editing Enrichment (TREE) and expresses a green and red fluorescent protein. How festive! hubs.la/H0TTm-y0
ALT plasmid map
Andrew Lu retweeted
Our new work on CONTENT, a powerful method for multi-context TWAS, is now on BioRxiv! Led by Mike Thompson and in collaboration with Noah Zaitlen, @yimmieg, Sasha Gusev, @halperineran, @andreww_lu et al. 🧵👇
biorxiv.org/content/10.1101/…
1/n
Andrew Lu retweeted
Mind blowing.
The FTO gene is associated with obesity in humans. Plants don't have a homolog. What happens when you transgenically express the human FTO in plants?
Giant potatoes and rice
nature.com/articles/s41587-0…
Andrew Lu retweeted
Excited to share new work w/ co-lead @CamilliaAzimi, @MarsonLab @kickassscience1 @roybal_lab: using a method we call 'CAR Pooling', we tested many CARs in multiplex & found new non-T cell signaling domains which improve CAR-T efficacy. biorxiv.org/cgi/content/shor… 👇🧵 1/10