Physician-Scientist at the University of Pittsburgh. K+ 🥑🍌 |🧂&💧| WNKs 😉 | Crowding 🔆 | Condensate Physiology 🎇 🦋 https://xitter.cf/t.co/p0CKnJBUUE
Pittsburgh, PA
Joined January 2015
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Our latest, now in print in @jclinicalinvest (w/ cover! 🎉) Led by @caryboyd3, we identified a functional role for #WNK bodies in K+ homeostasis, highlighting a #condensate 🫧 that can influence kidney physiology & nephron sexual dimorphism, w/ implications for human health 1/
Arohan Subramanya retweeted
Adjusted rate of ESKD incidence in the US, as seen in the new USRDS ADR. Hang it in the Louvre.
Was great to catch up with my
@CWRUSOM brother- the amazing @UChiPritzker pulmonologist and bronchoscopist extraordinaire @kylehogarth last weekend in Chicago. Pretty sure this guy can scope a bronchiole if he so chooses…
Arohan Subramanya retweeted
🧵1/
WNK bodies are biomolecular condensates in action—membraneless compartments that enable rapid, spatially organized control of NaCl transport based on dietary potassium. A new paradigm in renal signaling and homeostasis. 🧠🧪Here’s the story👇
#WNKbodies #RenalPhysiology
Thank you! @pittkidneyctr was essential for this project
As always, @arohan_s & @caryboyd3 have cutting edge research so stunning you’d think you were standing in an art gallery!
Keep WNK-ing, you two!
@PittDeptofMed @PittTweet @PittMedMag @tkleyman @RodTan07 @ManishaJhambMD @PAmarapurkar @RayRenal @ShiwarskiLab
Love the tagline!
A nod and a wink to kidney-specific WNK1
This issue’s cover features work by Cary R. Boyd-Shiwarski et al. @caryboyd3 on kidney-specific WNK1 as a scaffolding protein that organizes WNK bodies — structures essential for maintaining blood potassium levels: jci.org/articles/view/188792
More generally, this work extends beyond functional studies in cells to support the relevance of biomolecular #condensates in mammalian #physiology, while hinting @ intriguing connections between condensates & public health. 11/
Congrats to Cary Boyd-Shiwarski @caryboyd3 , who expertly saw this through as corresponding author, lab members & alums incl Becca Beacham & @Kate_Querry; and to our collabs incl @okashlan @CBI_Pitt @ShiwarskiLab Aylin Rodan @UofUNephrology Chou-Long Huang & Sean Stocker 🎉🥳/12
Last month, I completed a 4-year term on @NIH CSR's KUFD study section. Challenging work and I'm glad to emerge out of the triannual tunnel, but I will greatly miss the interactions with colleagues that made me a better scientist and were always 4 months around the corner.
Despite the diversity of expertise in KUFD, the study section was always unified in terms of its definition of merit. It's one of CSR's premier venues for kidney & bladder #physiology research, and I look forward to improving my own proposals there via the submission process.
Arohan Subramanya retweeted
Congrats to Katie Nguyen on her groundbreaking work presented at APS Summit #WeArePhysiology @pittkidneyctr @arohan_s
