@okashlan

Scientist at the University of Pittsburgh. Views are my own.

 Pittsburgh, Pennsylvania
Joined February 2009
  • Tweets19
  • Following82
  • Followers37
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Our new study! Bile acids are natural ligands for the epithelial sodium channel. Big thanks to the Pochynyuk and Lei groups for their help! physoc.onlinelibrary.wiley.c…
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Kidney-Specific KO of the Circadian Clock Protein PER1 Alters Renal Sodium Handling, Aldosterone Levels, and Kidney/Adrenal Gene Expression - new in @AJPRenal ow.ly/xoLz50HQHZG #homeostasis #articlesinpress
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Ossama Kashlan retweeted
The Onion
@TheOnion6 Feb 2022
‘I Want To Be In The Olympics Someday,’ Says Delusional Kindergartner Already 4 Years Behind In Elite Training bit.ly/3AXD8IL
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Excited to share our latest work in @eLife with @NathanClark111 on the evolution of a sodium channel crucial to kidney and lung function. elifesciences.org/articles/7…

Activation by cleavage of the epithelial Na+ channel α and γ subunits independently coevolved with...

Proteolytic activation of a sodium-permeable channel that aids in gas exchange and fluid homeostasis likely evolved at the water to land transition in vertebrates.

elifesciences.org
Nathan Clark nclark.bsky.social@NathanClark1115 Jan 2022
It was a delight to be part of this study w/ @okashlan on the evolution of kidney and lung ion homeostasis during the transition of vertebrates from ocean to dry land. doi.org/10.7554/eLife.75796

Activation by cleavage of the epithelial Na+ channel α and γ subunits independently coevolved with...

Proteolytic activation of a sodium-permeable channel that aids in gas exchange and fluid homeostasis likely evolved at the water to land transition in vertebrates.

elifesciences.org
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Adaptations to breathe air and conserve salt and water gave aquatic vertebrates access to new resources on land. These required molecular changes.
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Control over the activation of the #ENaC sodium channel through the addition of cleavage sites happened during the vertebrate land invasion. bit.ly/3K3d1Eb
If you don’t want to see big roly-poly pandas rolling down hills in a rare DC snowstorm then LOOK AWAY
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Really enjoyed @LabZhu Bokai Zhu's talk today about the 12-hour circatidal biological clock. Who knew we shared so much with clams? journals.plos.org/plosbiolog…

12-h clock regulation of genetic information flow by XBP1s

Distinct from the well-known 24-hour circadian clock, this study shows that the mammalian 12-hour clock upregulates genetic information flow capacity during the two "rush hours" (dawn and dusk) in a...

journals.plos.org
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It's hard to overstate the impact of their work. xitter.cf/NobelPrize/status/1313…
The Nobel Prize
@NobelPrize7 Oct 2020
BREAKING NEWS: The 2020 #NobelPrize in Chemistry has been awarded to Emmanuelle Charpentier and Jennifer A. Doudna “for the development of a method for genome editing.”
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Ossama Kashlan retweeted
Ramon Bataller
@rabataller5 Oct 2020
Nobel Prize in Medicine to the 3 scientists that discovered HEPATITIS C. A great recognition to the greatest achievement of hepatology. Now it is time to erradicate it !!
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NEWS: PA Sen Pat Toomey will not run for governor or reelection in 2022. Announcement expected Monday. He'll serve out his current senate term. w/ @wbender99 fusion.inquirer.com/politics…

Sen. Pat Toomey won’t run for reelection or for Pennsylvania governor, sources say

Toomey was widely seen as the likely Republican favorite for governor in 2022. His decision not to run for that office or for Senate could create two wide open contests on the Republican side.

inquirer.com
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Genetic consequence to the tragedy in Syria: wired.com/2015/04/syrians-sa…

How Syrians Saved an Ancient Seedbank From Civil War

When civil war broke out in Syria, Ahmed Amri immediately thought about seeds. Specifically, 141,000 packets of them sitting in cold storage 19 miles south of Aleppo.

wired.com
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