Scientist interested in cancer epigenetics, computational biology and anything in between. Associate Professor @PennEpiInst @PennCancer @PennPathLabMed
Philadelphia, PA
Joined June 2009
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Thrilled to see the latest work from our talented lab members @YeqiaoZhou and @atishay_jay
Three new manuscripts from Faryabi and Vahedi labs on chromatin folding, ORCA, oncogene regulation and T1D immunology. Individually great, collectively unstoppable. @golnaz_v @bfariabi @atishay_jay @PennEpiInst
tinyurl.com/4zaw5cn7
tinyurl.com/25snbf4j
tinyurl.com/4nwfbeu2
R. Babak Faryabi retweeted
1/ 🚨 Our new paper in @ImmunityCP ! How does cytokine signaling rewire the 3D genome as T cells choose their fate? We traced the disease-associated Ets1–Fli1 enhancer hub in single cells — one allele at a time — with super-resolution ORCA imaging. cell.com/immunity/fulltext/S…
Our collective work with @golnaz_v team describing the role of multi-enhancer spatial networks in mediating cytokine signaling at single-allele resolution is out at @ImmunityCP!
R. Babak Faryabi retweeted
Very excited to share our @ScienceMagazine paper on single-cell #3D #genome reorganization in #Alzheimer's disease.
We jointly measured gene expression and 3D genome architecture in individual human brain cells using #GAGEseq, then integrated these data w/ chromatin accessibility and spatial transcriptomics. We uncovered increased #compartment #mingling and distance-dependent rewiring of gene regulatory contacts in AD.
We also developed #Hicformer, a transformer-based model that integrates DNA sequence with 3D genome features to predict cell type-specific gene expression and prioritize candidate regulatory elements.
Huge kudos to co-first authors @zocean636 and @xinyuelu1999; and many thanks to Zhijun Duan @UW, Hansruedi Mathys @PittTweet, & David Bennett @rushalzheimers for the wonderful collaboration, as well as to all our co-authors. @CarnegieMellon @SCSatCMU @CMUCompBio #AlzheimersDisease #3DGenome #SingleCell #AI
science.org/doi/10.1126/scie…
R. Babak Faryabi retweeted
psm010 vodcast youtu.be/XC6xe_c65lg?si=LP8E… via @YouTube
How CAR T-Cell Therapy Enabled Kidney Transplants for Highly Sensitized Patients!
Vijay Bhoj, MD, PhD, explains how a novel CAR T-cell approach made kidney transplantation possible for patients previously considered unmatched, and why that could change outcomes for people waiting on dialysis.
@PennPathLabMed @PennMedCSO @PennMedicine @Penn @AmerTransplant @KidneyFund @ASNKidney @Uroweb @ESP_Pathology @TheUSCAP @PennPathLabMed
R. Babak Faryabi retweeted
I'm supporting Children's Hospital of Philadelphia Foundation! chop.donordrive.com/teams/So… via @DonorDrive
I am delighted to share that @YeqiaoZhou from our lab was awarded an NCI K99 grant! Her application scored in the 3% on its first submission- an outstanding achievement. @PennPathLabMed @PennEpiInst @pennbgs
R. Babak Faryabi retweeted
حمله ی گوربا به سمنو
نوروز پیروز 🪻
#پاينده_ایران
R. Babak Faryabi retweeted
Der Komiker Max zeigt seinen Zuschauern ein Video:
Seit fast fünf Jahrzehnten leiden Iraner unter Angst, Gewalt und Hoffnungslosigkeit.
Eine ganze Generation wächst ohne Freiheit auf – selbst Lachen, Musik oder Liebe fühlen sich wie ein Risiko an.
#FreeIran
R. Babak Faryabi retweeted
Ali Khamenei 1939-2026
👉 Dossier Municipales à Lyon : Lyon, zone tiède
👉 Khamenei : il nous manque déjà !
👉 Complotisme : les pyramides, aimants à zinzins
En vente mercredi !
R. Babak Faryabi retweeted
در روزهای آینده ما به هزاران هدف رژیم تروریستی ضربه خواهیم زد.
ما شرایطو برای مردم شجاع ایران فراهم خواهیم کرد تا خود را از زنجیرهای استبداد رها کنن.
و به همین دلیل من دوباره خطاب به شما میگم:
ای شهروندان ایران این فرصت رو از دست ندهید.
این فرصتی‌ست که فقط یه بار در هر نسل پیش میاد.
دست روی دست نگذارید چون به زودی لحظه شما فرا خواهد رسید.
لحظه‌ای که باید به خیابون‌ها بیایید، با حضور میلیونی‌تون به خیابون‌ها بیایید تا کارو تمام کنید، تا رژیم وحشتی را که زندگی‌تون رو تلخ کرده سرنگون کنید.
رنج و فداکاری شما بیهوده نخواهد بود.
کمکی که آرزوش رو داشتید، این کمک از راه رسیده است.
کمک از راه رسیده است و حالا زمان آن رسیده که برای یک مأموریت تاریخی با هم متحد شوید.
ای شهروندان ایران، پارسا، کردها، آذری‌ها، اهوازی‌ها و بلوچ‌ها -
اکنون زمان آن است که نیروهایتون رو متحد کنید تا رژیم رو سرنگون دارید و آینده خود را تضمین نمایید.
R. Babak Faryabi retweeted
BREAKING: Iranian Supreme Leader Ayatollah Ali Khamenei is dead, Iranian state media reports. apnews.com/live/live-updates…
R. Babak Faryabi retweeted
A dysregulated hepcidin-iron axis impairs antiviral immunity and induces lethal liver pathology in neonates @ImmunityCP
cell.com/immunity/fulltext/S… 🇨🇳
R. Babak Faryabi retweeted
ft. M. Abedi, P. Rai, Y. Zhou, C. Liu, I. Johnson, A. Chandra, M. Fasolino, S. Rostami, W. Wang, Z. Min, Y. Li, M. Yu, @atishay_jay, V. Lian, M. Silverman, @KaestnerKlaus, A. Naji, @bfariabi & @golnaz_v @PennGenetics @UPenn_I3H @PennEpiInst @PennIDOM science.org/doi/10.1126/scii…
R. Babak Faryabi retweeted
Lineage-determining transcription factors (EBF1 & TCF1) radially position enhancers within gene loci to enable multi-enhancer regulation of key oncogenes at the single-allele level @NatureCellBio @PennMedicine @YeqiaoZhou @atishay_jay @golnaz_v @bfariabi
nature.com/articles/s41556-0…
Congratulations to Naomi and the rest of the trainees at @PennEpiInst and @UPenn_I3H for their amazing work. Proud to be part of it!
Incredibly proud of a new study, led by brilliant Naomi Goldman, demonstrating for the first time that the intrinsically disordered domain of TCF-1 is critical for T cells. We are grateful to exceptional collaboration in @vahedilab and beyond
tinyurl.com/yj462k8s