co-founder/ceo at @cadrian_ai. former partner at @ardent_vc.

sf / dc
Joined March 2009
Today, @cadrian_ai is exiting stealth, and I couldn't be more proud. We set out to help organizations become AI-enabled, and here's what we found and why it matters: 👇
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dan preiss retweeted
World model for biomedicine. I am seeing WMs cross domain in addition to the physical world: predicting future events, predicting business outcomes, ect. What LLM’s did for language world models do for consequences.
Excited to share that "World models for biomedicine" is out in @CellCellPress, by stellar @ayushnoori @njwfish @AdaFang_ Lukas Fesser doi.org/10.1016/j.cell.2026.… In AI, a world model represents the state of a system and simulates how it evolves under alternative actions Game agents and robots use world models to test actions internally before executing them We ask what world models mean for biology, from molecules to cells, tissues, and patients A biomedical world model maps observations across modalities to a model state, takes an action (a drug, a knockout, a change in culture conditions), predicts a distribution over next states, and continues simulation from its own predictions What data and evaluations do we need to make this possible?
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Long-running agents create a new requirement for companies: an explicit model of the job. Not just the workflow, but the decisions, exceptions, handoffs, escalation paths, etc. For most knowledge work, that model doesn’t exist in one place today. It’s scattered across systems, documents and, hardest of all, people. Highly recommend reading @seema_amble’s article in thread below.
We’re talking a lot about long running/horizon agents now but owning the full job and getting these learning loops right is so important to enabling agents to do work over hours or days, through a complex logic chain with many in between decisions and handoffs
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Apple should buy Instinct.
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But this will soon work for any operational question. You will be able to ask Cadrian anything about how your company runs and get the answer straight from your team.
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The answers are already in your company. We help you get them out. If you're looking to get unstuck on AI, shoot me a DM!
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Dc not allowing Waymo for safety reasons is insane when there's no ban on Maryland drivers
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Check out @pbronner’s Why We Invested on Sooth Labs. Phenomenal team with a big idea.
We backed @soothlabs at seed. Here's why. The team. @subail founded and scaled Meta's Pittsburgh AI office and serves on CMU's Robotics Institute faculty. @rsalakhu Salakhutdinov is a @SCSatCMU professor, a pioneer in modern generative modeling, Apple's first director of AI research, and a disciple of Geoffrey Hinton. Chuck Hoover directed billion-dollar innovation programs at Meta. $50M round led by @felicis at a $335M valuation. Angel investment from @ylecun and @JeffDean. Andrew Bosworth is advising. What they're building: a continuously trained world model for long-horizon forecasting. It takes verifiable propositions (Will Brent crude exceed $90/bbl in March 2027? Will US CPI exceed 4% YoY in 2026?) and returns calibrated probabilities with a structured causal timeline of driving events. Institutions commit capital in the face of deep uncertainty every day, and the stakes keep rising while the tools haven't moved. Strategy still gets set with gut calls, internal models, and the occasional expert opinion. Specialist platforms exist in finance, insurance, and energy, but each operates within a single domain and is rarely measured against what actually happens. Foresight should be a system, not a skill. LLMs aren't the answer here. They're optimized to generate plausible text, not to produce probabilities graded against real events. Sooth is built on a different architecture designed for exactly that job, with a causal chain users can interrogate, revise, and stress-test as conditions change. Congrats to Yaser, Russ, Chuck, and the team.
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dan preiss retweeted
Which emerging VCs have the strongest early-stage picking alpha? Standard emerging manager evaluation still leans heavily on qualitative signals – GP background, thesis articulation, founder references. All useful, but by the time TVPI and DPI tell you something meaningful, you're usually already in or already too late. So I experimented with a quantitative framework to answer a core LP allocator question: which small, early-stage fund managers consistently back seed-stage companies that go on to raise exceptional Series A rounds – before those outcomes are visible to the broader market? I started with @harmonic_ai Scout (my fav research tool!) and checked every company globally that raised a first pre-seed or seed round between 2022–2026 (Post-ZIRP). The funnel looks like this: 1/ 55,491 companies raised a pre-seed or seed round – the full opportunity set 2/ 4,368 (7.9%) went on to raise a Series A – the base rate, roughly 1 in 13 3/ 764 (1.4%) qualified as Tier 1 Breakouts – above-median Series A for their vintage year, with at least one top-tier institutional VC (from a defined set of 38 firms: @a16z, @sequoia, @lightspeedvp, @IndexVentures, and peers) For each of those 1,604 companies, I traced back to every investor who backed them at pre-seed or seed — before the outcome was visible. 4,176 unique investors across the breakout set. Then I computed a simple ratio for each: breakout companies backed at seed divided by total seed investments in the period. I'm calling this the "Tier 1 Concentration Rate". After filtering out mega-platforms, accelerators, CVCs, and angels and requiring a minimum of 10 seed deals – 20 emerging managers (sub-$250M AUM) surfaced with notably high concentration rates. A few things stood out: 1/ Several micro-funds under $100M were placing 25–35% of their seed bets into companies that later raised from @Sequoia, @a16z, @lightspeedvp – consistently, not as one-off flukes. 2/ Participant concentration and lead concentration are different signals. Participant = network and access. Lead = independent conviction before consensus forms. For LP diligence, these deserve to be evaluated separately. 3/ The data has real limitations: ~12% of breakout companies had no named seed investor in the database, we can't cleanly separate Fund I from Fund III for a given manager, and small sample sizes mean some high concentration rates likely reflect luck rather than repeatable skill. But the core idea holds. "Tier 1 Concentration Rate" is an early, measurable signal of picking ability – observable years before fund-level metrics tell you anything. For LP allocators evaluating Fund I–III managers, that timing gap is the whole problem. This is one attempt to close it. What’s your take on this experiment?
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Fun fact: Nokia started as a paper mill.
$BIRD is selling its brand and footwear assets renaming itself NewBird AI and using a new $50M convertible facility to pivot into AI compute infrastructure by buying GPUs. Going from selling wool sneakers to chasing AI compute might be one of the wildest pivots this cycle.
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This is the future of malleable software. This isn't just a chat agent in your CRM. This is an agent capable of building new features within your app. This will have massive implications. Still wrapping my head around it...
DenchClaw has now made it to the Hacker News frontpage 🚀 Also, we just hit 500 stars on GitHub 🦞 news.ycombinator.com/item?id…
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AI is unlocking massive gains for those who know how to use it and creating liabilities (accuracy, quality, taste) for those that don’t.
Four types of people at every company now yes, people get 10x better when the go from bottom right to top right but also, people get 10x worse when they go from bottom left to top left
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dan preiss retweeted
In order to have a sense of AI adoption right now, you really need to have one foot at the bleeding edge with the kids Wispr-ing through a mic at Devin all day and one foot in the 99% enterprise world where they’re still debating the merits of leaving “bundled-MSFT-ELA-Copilot”
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Someone launched a website where AI agents hire humans for their bodies We’re not even the main characters in the simulation anymore
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