@dellaVolpe_L

Postdoc @Bloodgenes. PhD @DiMiccoLab. Intrigued by Hematopoietic stem cell biology🩸, committed to advancing regenerative medicine 🧬🦠🧫

 Boston, MA
Joined November 2022
  • Tweets37
  • Following79
  • Followers51
1/n 📢 🚨 Excited to share that our latest findings from @bloodgenes lab is now out in @NatureCellBio! We discovered that #ferroptosis is a key barrier to #HSC survival during ex vivo culture. 👇Here is the story 👇 nature.com/articles/s41556-0…

Inhibiting ferroptosis enhances ex vivo expansion of human haematopoietic stem cells

Nature Cell Biology - della Volpe et al. augment the ex vivo expansion potential of human haematopoietic stem cells (HSCs) by inhibiting ferroptosis with liproxstatin-1 or ferrostatin-1. Treated...

nature.com
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Lucrezia della Volpe retweeted
Vijay Sankaran
@bloodgenesSep 30
🩸🧬 Delighted to share our new @Nature paper! Genetic studies of >28,000 people reveal a BACH2–NRF2 pathway for activating fetal hemoglobin, suggesting new tx avenues for sickle cell disease & β-thalassemia. Led by the amazing @guo_chunjie & co! nature.com/articles/s41586-0…

Human genetics implicates a BACH2–NRF2 axis in fetal haemoglobin activation

Nature - BACH2 restrains activation of the fetal-haemoglobin-encoding γ-globin genes, while loss of BACH2 enhances NRF2 chromatin occupancy and promotes the formation of activation foci at the...

nature.com
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Anna-Lena Neehus@ALNeehusAug 7
Happy to share the preprints of two complimentary studies from my Postdoc with @bloodgenes: We set out to understand the mechanisms underlying inherited childhood B cell lymphoblastic leukemia (B-ALL): biorxiv.org/content/10.64898… biorxiv.org/content/10.64898…

A functional genomics screen of human B-cell differentiation reveals convergent mechanisms of...

B-cell acute lymphoblastic leukemia (B-ALL) is the most common childhood cancer, yet the mechanisms by which inherited risk variants predispose to leukemia development remain poorly understood. A...

biorxiv.org
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Ofir Cohn@CohnOfirJun 2
Decades of research have revealed the intricacies of how dendritic cells (DCs) function, but fundamental questions remain about how this group of cells develops in humans and how this process goes awry in disease. A thread on our new work! (1/9) biorxiv.org/content/10.64898…
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Vijay Sankaran
@bloodgenesJun 2
🩸🧬 Dendritic cells are rare but key players in immunity. In a new preprint led by @CohnOfir, we generate a single-cell multi-omic atlas of human dendritic cell differentiation to reveal links to immune-mediated disease: biorxiv.org/content/10.64898…
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Vijay Sankaran
@bloodgenesMay 1
🚨 Excited to share a new paper in Cell! Human genetics led us to HOTSCRAMBL, a HOXA-locus lncRNA that regulates 🩸#stemcell self-renewal and HOXA9 splicing, with implications for AML. Amazing work by @lvchosen1 with @silvirouskin, @Armstrong_dfci, and many more! cell.com/cell/fulltext/S0092…
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Vijay Sankaran
@bloodgenesMar 30
❓A one-time, durable, and even reversible way to prevent thrombosis? In this preprint, led by @lrbzldz, we show that epigenome editing of 🩸 #StemCells can durably reprogram platelet function: biorxiv.org/content/10.64898…
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Anna-Lena Neehus@ALNeehusJan 15
Excited to share our latest work published today in @NatImmunol! 🎉 Together with Taja Vatovec, we investigated how somatic CBL deficiency affects B cell development and function. nature.com/articles/s41590-0…

Somatic deficiency of the human E3 ubiquitin ligase CBL in leukocytes impairs B cell but not T cell...

Nature Immunology - Bohlen and colleagues report that the E3 ubiquitin ligase CBL is necessary for the development, tolerance and activation of B cells in humans, unlike in mice where CBL...

nature.com
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Vijay Sankaran
@bloodgenesJan 2
Delighted to have our work on 🧬 resilience to 🩸cancer led by @GauravA_UK & amazing collaborators, including @KharasLab, published in @ScienceMagazine: science.org/doi/10.1126/scie… 🧵
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Honored to see our study featured in this Nature Cell Biology News & Views piece by @CterminiPhD and Isabella Alves: nature.com/articles/s41556-0… Deeply grateful to @bloodgenes and all colleagues who made this possible. 💙🧬
Tina Termini@CterminiPhD1 Dec 2025
Truly enjoyed writing this piece about recent discoveries by @dellaVolpe_L, @bloodgenes, and colleagues about how we can improve HSC expansion & gene editing by blocking ferroptosis! Our @NatureCellBio N&V: rdcu.be/eR25t Associated article: tinyurl.com/msf9x8fn
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Vijay Sankaran
@bloodgenes1 Dec 2025
How did the devastation of the atomic bombings 80 years ago ultimately help give rise to bone marrow transplantation and modern #stemcell biology? Our historical commentary with @JGudera in @NatureCellBio explores these unappreciated connections: nature.com/articles/s41556-0…
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Stem Cell Podcast
@stemcellpodcast27 Nov 2025
🩸 Dr. Lucrezia @dellaVolpe_L and a team in Dr. Vijay Sankaran's lab (@bloodgenes) discovered that ferroptosis is a key barrier to HSC survival during ex vivo culture. Read their paper in @NatureCellBio: go.nature.com/4ib4Ln6 Listen to the discussion: bit.ly/44kEZqM
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Hematopoiesis News
@Hema_News25 Nov 2025
RhoA is a key regulator of #HSCs mechanosignaling. Dr. @PaulaPetrone1 (@ISGLOBALorg) and Dr. Carolina Florian (@idibell_cat) show an intrinsic RhoA-dependent mechanosignaling axis which can be pharmacologically targeted to restore aged stem cell function: go.nature.com/47ZqPh5
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Vijay Sankaran
@bloodgenes19 Nov 2025
Ferroptosis and 🩸 stem cell biology have a lot to say to each other... Hoping this work inspires #ferroptosis researchers to explore HSCs and #hematopoiesis researchers to lean into ferroptosis 🤝
Vijay Sankaran
@bloodgenes18 Nov 2025
Excited to share our new study, led by @dellaVolpe_L, now out in @NatureCellBio! Blocking #ferroptosis enhances human 🩸 stem cell expansion, with implications for transplantation and gene therapy. nature.com/articles/s41556-0…
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Hematopoiesis News
@Hema_News19 Nov 2025
New release from @NatureCellBio! Researchers led by Drs. @dellaVolpe_L & Vijay Sankaran (@bloodgenes) showed that HSC loss in existing culture methods is driven largely by ferroptosis and that it can be blocked to augment HSC expansion. ✅ go.nature.com/4ib4Ln6
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Vijay Sankaran
@bloodgenes18 Nov 2025
Excited to share our new study, led by @dellaVolpe_L, now out in @NatureCellBio! Blocking #ferroptosis enhances human 🩸 stem cell expansion, with implications for transplantation and gene therapy. nature.com/articles/s41556-0…
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9/n ❤️A huge thank you to Vijay and everyone in the lab with a special shout out to this amazing frieds and colleagues Andrew, Mateusz, Teng, @guo_chunjie, Tianyi, Peng, Jorge, Nicole, and @yanirisma__ 🙏
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10/n 💖 I am incredibly grateful to be part of such an inspiring team, and this discovery would not have been possible without each of you. 🧬
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