Conversational portraits of original people by @jacksondahl. https://xitter.cf/t.co/9O2WSqysgP https://xitter.cf/t.co/jcfchWCZ9Q https://xitter.cf/t.co/PXCLZ6J6cc https://xitter.cf/t.co/f1QhDSsbXv
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60: Patrick Hsu - Speedrunning the Infinite Game
Dialectic 60: Patrick Hsu!
@pdhsu & @arcinstitute are combining biology, engineering, and AI to turn a sci-fi future into reality.
Patrick got expelled from college at 13, returned at 15, later worked on early CRISPR breakthroughs, and teamed up with @SKonermann & @patrickc to found Arc.
He works 3 jobs: core investigator at Arc, professor at Stanford, and venture partner at @thrivecapital. For all his intensity and ambition, he carries a lightness and boldness that is contagious.
We discuss:
- why research is 99% failure and even your best ideas kind of suck
- infinite games and speedrunning school
- the reach of GLP-1s and power laws in biotech
- what makes a good biologist
- Arc’s bet on people over projects
- lab robots that finally work
- AI-designed organisms and new forms of life
- why heart disease could go the way of infectious disease
- bro science, peptides, and biofuturism
- research taste in the age of AI
Timestamps:
(0:00) Opening Highlights
(1:39) Intro: Patrick Hsu
(4:29) Start: Boldness, Infinite Games, & Ambition
(12:54) GLP-1s and Power Laws in Biotechnology
(20:17) Expelled at 13 and Falling for Biology
(25:51) What Makes a Good Biologist, Research Taste, and Biology's Data Challenges
(37:58) The Arc Model: Full-Stack Science
(52:01) Betting on People, Style, & Learning to Simplify
(57:22) Perturbation, World Models, and Evo
(1:03:27) Virtual Cell Models
(1:09:56) Designing Life: From Stem Cells to Genome Writing
(1:18:39) Testing, Bro Science, and Human Data
(1:24:26) Can It Exist vs. Will It Exist: Science Meets Markets
(1:29:59) Biofuturism: Interoception, Peptides, Muscle Modulation, Sleep, and New Forms of Life
(1:43:47) Fun, Obsolescence, Going Slow, and the Future
@dialecticpod 60: Patrick Hsu - Speedrunning the Infinite Game - is available on all platforms, including X. Links below.
Dialectic with Jackson Dahl retweeted
This conversation shows why working with Josh is so lovely. He enables people to be their best selves, pursue big ideas, and be unafraid to think of product as art.
Dialectic 61: Josh Miller!
@joshm has always been thoughtful about the spaces we spend time in.
The browser is "really a rectangle that we spend eight hours a day in." So "why would we not want to live in a good rectangle?"
Josh sat down with me to reflect on @browsercompany's journey about a year after it was acquired by @Atlassian.
We talked about everything from the original decision to "optimize for feelings" to hiring unlikely stars to where Dia and the browser stand in the AI era.
Above all else, Josh believes in people. I’ve felt that, as have so many others who’ve collaborated with him or simply been around him.
I hope you’re inspired to believe in people too, and to leave your fingerprints on the things you make.
Timestamps:
(0:00) - Opening Highlights
(1:19) - Intro: Josh Miller
(3:14) - Start: Not Commercial Enough & Optimizing for Feelings
(10:33) - Sociology, the Obama White House, Thrive, and the 5% Favicon
(16:57) - Bowling Alone, James Turrell, and Roden Crater
(23:31) - Betting on People, Leaving Thrive, and Where Computing Goes
(36:13) - "Assume You Don't Know" and What Was Sacred at The Browser Company
(43:17) - Intuition, Road Trips, and Leaving Fingerprints on Things
(55:16) - Building in Public, Pulling Back, and the Road to Atlassian
(1:04:42) - The Internet Computer in the AI Era: Codex, Cloud Browsers, and Why Everything Is Converging
(1:14:49) - How Dia Wins
(1:18:26) - Agents, Muse, and the Red Giraffe
(1:24:02) - Software Is Becoming Art
(1:33:32) - Believing in People, Leaving Facebook for the White House, and What's Next
(1:48:36) - Closing Questions
@dialecticpod 61: Josh Miller - A Good Rectangle - is out now, below and on all platforms.
Dialectic with Jackson Dahl retweeted
@joshm has inspired so much of my thinking on how we can make technology products into friendlier / more personal spaces... Lots of early branch / potluck (and browser co!) spirit in Tolan today :)
Dialectic 61: Josh Miller!
@joshm has always been thoughtful about the spaces we spend time in.
The browser is "really a rectangle that we spend eight hours a day in." So "why would we not want to live in a good rectangle?"
Josh sat down with me to reflect on @browsercompany's journey about a year after it was acquired by @Atlassian.
We talked about everything from the original decision to "optimize for feelings" to hiring unlikely stars to where Dia and the browser stand in the AI era.
Above all else, Josh believes in people. I’ve felt that, as have so many others who’ve collaborated with him or simply been around him.
I hope you’re inspired to believe in people too, and to leave your fingerprints on the things you make.
Timestamps:
(0:00) - Opening Highlights
(1:19) - Intro: Josh Miller
(3:14) - Start: Not Commercial Enough & Optimizing for Feelings
(10:33) - Sociology, the Obama White House, Thrive, and the 5% Favicon
(16:57) - Bowling Alone, James Turrell, and Roden Crater
(23:31) - Betting on People, Leaving Thrive, and Where Computing Goes
(36:13) - "Assume You Don't Know" and What Was Sacred at The Browser Company
(43:17) - Intuition, Road Trips, and Leaving Fingerprints on Things
(55:16) - Building in Public, Pulling Back, and the Road to Atlassian
(1:04:42) - The Internet Computer in the AI Era: Codex, Cloud Browsers, and Why Everything Is Converging
(1:14:49) - How Dia Wins
(1:18:26) - Agents, Muse, and the Red Giraffe
(1:24:02) - Software Is Becoming Art
(1:33:32) - Believing in People, Leaving Facebook for the White House, and What's Next
(1:48:36) - Closing Questions
@dialecticpod 61: Josh Miller - A Good Rectangle - is out now, below and on all platforms.
Dialectic with Jackson Dahl retweeted
Still on the fence about @ndstudio? Here’s @jgebbia’s pitch:
- An install base of 340 million users on day one.
- A fix you ship this week shows up on your mom’s phone.
- Your parents, grandparents, siblings, and friends are among the people you’re building for.
"Nobody on our team was thinking about the government at all. It wasn’t on anybody’s career plans whatsoever."
Dialectic with Jackson Dahl retweeted
“Red giraffe on a screen!”
Fun listen w/ @joshm @jacksondahl. Lot if great ideas on how consumer and enterprise are different + alike in an AI universe…
Dialectic with Jackson Dahl retweeted
61: Josh Miller - A Good Rectangle
Dialectic 61: Josh Miller!
@joshm has always been thoughtful about the spaces we spend time in.
The browser is "really a rectangle that we spend eight hours a day in." So "why would we not want to live in a good rectangle?"
Josh sat down with me to reflect on @browsercompany's journey about a year after it was acquired by @Atlassian.
We talked about everything from the original decision to "optimize for feelings" to hiring unlikely stars to where Dia and the browser stand in the AI era.
Above all else, Josh believes in people. I’ve felt that, as have so many others who’ve collaborated with him or simply been around him.
I hope you’re inspired to believe in people too, and to leave your fingerprints on the things you make.
Timestamps:
(0:00) - Opening Highlights
(1:19) - Intro: Josh Miller
(3:14) - Start: Not Commercial Enough & Optimizing for Feelings
(10:33) - Sociology, the Obama White House, Thrive, and the 5% Favicon
(16:57) - Bowling Alone, James Turrell, and Roden Crater
(23:31) - Betting on People, Leaving Thrive, and Where Computing Goes
(36:13) - "Assume You Don't Know" and What Was Sacred at The Browser Company
(43:17) - Intuition, Road Trips, and Leaving Fingerprints on Things
(55:16) - Building in Public, Pulling Back, and the Road to Atlassian
(1:04:42) - The Internet Computer in the AI Era: Codex, Cloud Browsers, and Why Everything Is Converging
(1:14:49) - How Dia Wins
(1:18:26) - Agents, Muse, and the Red Giraffe
(1:24:02) - Software Is Becoming Art
(1:33:32) - Believing in People, Leaving Facebook for the White House, and What's Next
(1:48:36) - Closing Questions
@dialecticpod 61: Josh Miller - A Good Rectangle - is out now, below and on all platforms.
Dialectic with Jackson Dahl retweeted
always walk away from a Josh Miller interview with things percolating in my brain
Dialectic 61: Josh Miller!
@joshm has always been thoughtful about the spaces we spend time in.
The browser is "really a rectangle that we spend eight hours a day in." So "why would we not want to live in a good rectangle?"
Josh sat down with me to reflect on @browsercompany's journey about a year after it was acquired by @Atlassian.
We talked about everything from the original decision to "optimize for feelings" to hiring unlikely stars to where Dia and the browser stand in the AI era.
Above all else, Josh believes in people. I’ve felt that, as have so many others who’ve collaborated with him or simply been around him.
I hope you’re inspired to believe in people too, and to leave your fingerprints on the things you make.
Timestamps:
(0:00) - Opening Highlights
(1:19) - Intro: Josh Miller
(3:14) - Start: Not Commercial Enough & Optimizing for Feelings
(10:33) - Sociology, the Obama White House, Thrive, and the 5% Favicon
(16:57) - Bowling Alone, James Turrell, and Roden Crater
(23:31) - Betting on People, Leaving Thrive, and Where Computing Goes
(36:13) - "Assume You Don't Know" and What Was Sacred at The Browser Company
(43:17) - Intuition, Road Trips, and Leaving Fingerprints on Things
(55:16) - Building in Public, Pulling Back, and the Road to Atlassian
(1:04:42) - The Internet Computer in the AI Era: Codex, Cloud Browsers, and Why Everything Is Converging
(1:14:49) - How Dia Wins
(1:18:26) - Agents, Muse, and the Red Giraffe
(1:24:02) - Software Is Becoming Art
(1:33:32) - Believing in People, Leaving Facebook for the White House, and What's Next
(1:48:36) - Closing Questions
@dialecticpod 61: Josh Miller - A Good Rectangle - is out now, below and on all platforms.
Dialectic with Jackson Dahl retweeted
One year after the @browsercompany deal closed, I had a two-hour conversation with Jackson about it all…
Dialectic 61: Josh Miller!
@joshm has always been thoughtful about the spaces we spend time in.
The browser is "really a rectangle that we spend eight hours a day in." So "why would we not want to live in a good rectangle?"
Josh sat down with me to reflect on @browsercompany's journey about a year after it was acquired by @Atlassian.
We talked about everything from the original decision to "optimize for feelings" to hiring unlikely stars to where Dia and the browser stand in the AI era.
Above all else, Josh believes in people. I’ve felt that, as have so many others who’ve collaborated with him or simply been around him.
I hope you’re inspired to believe in people too, and to leave your fingerprints on the things you make.
Timestamps:
(0:00) - Opening Highlights
(1:19) - Intro: Josh Miller
(3:14) - Start: Not Commercial Enough & Optimizing for Feelings
(10:33) - Sociology, the Obama White House, Thrive, and the 5% Favicon
(16:57) - Bowling Alone, James Turrell, and Roden Crater
(23:31) - Betting on People, Leaving Thrive, and Where Computing Goes
(36:13) - "Assume You Don't Know" and What Was Sacred at The Browser Company
(43:17) - Intuition, Road Trips, and Leaving Fingerprints on Things
(55:16) - Building in Public, Pulling Back, and the Road to Atlassian
(1:04:42) - The Internet Computer in the AI Era: Codex, Cloud Browsers, and Why Everything Is Converging
(1:14:49) - How Dia Wins
(1:18:26) - Agents, Muse, and the Red Giraffe
(1:24:02) - Software Is Becoming Art
(1:33:32) - Believing in People, Leaving Facebook for the White House, and What's Next
(1:48:36) - Closing Questions
@dialecticpod 61: Josh Miller - A Good Rectangle - is out now, below and on all platforms.
61: Josh Miller - A Good Rectangle
Dialectic 61: Josh Miller!
@joshm has always been thoughtful about the spaces we spend time in.
The browser is "really a rectangle that we spend eight hours a day in." So "why would we not want to live in a good rectangle?"
Josh sat down with me to reflect on @browsercompany's journey about a year after it was acquired by @Atlassian.
We talked about everything from the original decision to "optimize for feelings" to hiring unlikely stars to where Dia and the browser stand in the AI era.
Above all else, Josh believes in people. I’ve felt that, as have so many others who’ve collaborated with him or simply been around him.
I hope you’re inspired to believe in people too, and to leave your fingerprints on the things you make.
Timestamps:
(0:00) - Opening Highlights
(1:19) - Intro: Josh Miller
(3:14) - Start: Not Commercial Enough & Optimizing for Feelings
(10:33) - Sociology, the Obama White House, Thrive, and the 5% Favicon
(16:57) - Bowling Alone, James Turrell, and Roden Crater
(23:31) - Betting on People, Leaving Thrive, and Where Computing Goes
(36:13) - "Assume You Don't Know" and What Was Sacred at The Browser Company
(43:17) - Intuition, Road Trips, and Leaving Fingerprints on Things
(55:16) - Building in Public, Pulling Back, and the Road to Atlassian
(1:04:42) - The Internet Computer in the AI Era: Codex, Cloud Browsers, and Why Everything Is Converging
(1:14:49) - How Dia Wins
(1:18:26) - Agents, Muse, and the Red Giraffe
(1:24:02) - Software Is Becoming Art
(1:33:32) - Believing in People, Leaving Facebook for the White House, and What's Next
(1:48:36) - Closing Questions
@dialecticpod 61: Josh Miller - A Good Rectangle - is out now, below and on all platforms.
Transcript & Links: dialectic.fm/josh-milller
Spotify: open.spotify.com/episode/3at…
Apple: podcasts.apple.com/us/podcas…
YouTube: youtu.be/npYk9iarhRU?si=CSWd…
Still on the fence about @ndstudio? Here’s @jgebbia’s pitch:
- An install base of 340 million users on day one.
- A fix you ship this week shows up on your mom’s phone.
- Your parents, grandparents, siblings, and friends are among the people you’re building for.
"Nobody on our team was thinking about the government at all. It wasn’t on anybody’s career plans whatsoever."
Dialectic with Jackson Dahl retweeted
“It’s not the money. It's the appetite for reputational risk.”
Adam Mastroianni on why new science institutions end up looking exactly like the old ones.
58: Adam Mastroianni - Let Me Be Useful
Transcript & links: dialectic.fm/adam-mastroiann…
Spotify: open.spotify.com/episode/74L…
Apple: podcasts.apple.com/us/podcas…
YouTube: youtube.com/watch?v=pHhn1fHy…
“I can’t go ham the way I did in my teens.”
@pdhsu on learning to use the brakes:
"I kind of specialize in not burning out."
"You have to know when to go slow a lot of the time."
"Slow is smooth and smooth is fast."
Dialectic with Jackson Dahl retweeted
An antidote to obsolescence: “Personal Renewal” by John W. Gardner.
Listen on Spotify: open.spotify.com/show/2IEN4e…
or Apple: podcasts.apple.com/us/podcas…
Read the original Transcript with PBS: pbs.org/johngardner/sections…
Dialectic with Jackson Dahl retweeted
Do you fear becoming obsolete?
The bad news: if you simply do nothing, obsolescence is the default.
The good news: there’s a way out.
Patrick Hsu on why boldness and risk-taking are survival traits, not personality traits.
Dialectic with Jackson Dahl retweeted
Patrick is such a joy to work with at Arc!
Dialectic 60: Patrick Hsu!
@pdhsu & @arcinstitute are combining biology, engineering, and AI to turn a sci-fi future into reality.
Patrick got expelled from college at 13, returned at 15, later worked on early CRISPR breakthroughs, and teamed up with @SKonermann & @patrickc to found Arc.
He works 3 jobs: core investigator at Arc, professor at Stanford, and venture partner at @thrivecapital. For all his intensity and ambition, he carries a lightness and boldness that is contagious.
We discuss:
- why research is 99% failure and even your best ideas kind of suck
- infinite games and speedrunning school
- the reach of GLP-1s and power laws in biotech
- what makes a good biologist
- Arc’s bet on people over projects
- lab robots that finally work
- AI-designed organisms and new forms of life
- why heart disease could go the way of infectious disease
- bro science, peptides, and biofuturism
- research taste in the age of AI
Timestamps:
(0:00) Opening Highlights
(1:39) Intro: Patrick Hsu
(4:29) Start: Boldness, Infinite Games, & Ambition
(12:54) GLP-1s and Power Laws in Biotechnology
(20:17) Expelled at 13 and Falling for Biology
(25:51) What Makes a Good Biologist, Research Taste, and Biology's Data Challenges
(37:58) The Arc Model: Full-Stack Science
(52:01) Betting on People, Style, & Learning to Simplify
(57:22) Perturbation, World Models, and Evo
(1:03:27) Virtual Cell Models
(1:09:56) Designing Life: From Stem Cells to Genome Writing
(1:18:39) Testing, Bro Science, and Human Data
(1:24:26) Can It Exist vs. Will It Exist: Science Meets Markets
(1:29:59) Biofuturism: Interoception, Peptides, Muscle Modulation, Sleep, and New Forms of Life
(1:43:47) Fun, Obsolescence, Going Slow, and the Future
@dialecticpod 60: Patrick Hsu - Speedrunning the Infinite Game - is available on all platforms, including X. Links below.
Do you fear becoming obsolete?
The bad news: if you simply do nothing, obsolescence is the default.
The good news: there’s a way out.
Patrick Hsu on why boldness and risk-taking are survival traits, not personality traits.
An antidote to obsolescence: “Personal Renewal” by John W. Gardner.
Listen on Spotify: open.spotify.com/show/2IEN4e…
or Apple: podcasts.apple.com/us/podcas…
Read the original Transcript with PBS: pbs.org/johngardner/sections…
Dialectic with Jackson Dahl retweeted
Sometimes the secret is just knowing someone else has done it.
@pdhsu on why one breakthrough can unlock others.
Sometimes the secret is just knowing someone else has done it.
@pdhsu on why one breakthrough can unlock others.