Anesthesiologist, Neuroscientist, Explorer. Views are my own.
Joined September 2021
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Li Li, MD, PhD retweeted
Pls Chk out the lab's recent work from Eric Zhang (not on X), now in press & pre-printed. "Dentate Gyrus Norepinephrine Ramping Facilitates Aversive Contextual Processing". Thanks to @yulonglilab for the early collab using GRAB-NE2m.
biorxiv.org/content/10.1101/…
Li Li, MD, PhD retweeted
Excited to present my work in the @mbruchas lab and visions for my own lab @SinaiBrain on August 27!
📅 Save the date for our upcoming seminar on August 27th! 🧠
Join us as @outRaajeous from the @mbruchas lab at @UW dives into how endogenous opioid release in the dorsal striatum influences goal-directed behavior, hosted by @Tamaramaneuro, @BrandonHughes90, and @veronikakondev.
Li Li, MD, PhD retweeted
Chk out our @NAPECenter 5th annual Imaging and Genetics Workshop this fall (10/21-10/24/24) in Seattle, WA Thx @NIDAnews for support. Please register/apply now. Reach out to me,@gstuber or @NAPECenter for more details. Local, US and international attendees are welcome!
Li Li, MD, PhD retweeted
1/4 🧠 Our latest study - published in @eLife, exploring the pivotal role of the supramammillary nucleus (SuM) in stress resilience! doi.org/10.7554/eLife.90972
We discovered that glutamatergic neurons SuM play a crucial role in responding to stress and promoting active coping behaviors. With @mbruchas and @LexKravitz
🔬 We identified SuMVGLUT2+ neurons projecting to the preoptic area (POA). These neurons arborize to connect with key stress response regions, revealing the complex networks behind coping strategies. 🧩
Excited to share our preprint “Noradrenergic tuning of arousal is coupled to coordinated movements” from @mbruchas' lab.
biorxiv.org/content/10.1101/…
How does an animal coordinate arousal and movement?
In awake animals, we found that LC-NE activation and deactivation were associated with movement initiations and arrests, respectively. These observations suggest LC’s more nuanced role in coupling arousal and movement.
Many thanks to my other co-authors Akshay Rana, Esther Li, and Myesa Travis; the Bruchas lab; and #NIDA, @FAERanesthsia, @UWAnesthPainMed, @NAPECenter, @seattlechildren
Li Li, MD, PhD retweeted
Eating a lot of potato chips or ice cream when you're stressed? Don't worry, you're not alone. We found mice binge eating palatable food (high sugar, high fat) after acute stressors as well.
Endogenous opioids facilitate stress-induced binge eating via an insular cortex-claustrum pathway biorxiv.org/cgi/content/shor… #biorxiv_neursci
Li Li, MD, PhD retweeted
Happy to share this @ahmari_lab work co-led by myself, @DrLizzieManning and @britt_lynn4, with critical help from @vijay_mkn and @DrJamiePierson!
We investigated how striatal spiny projection neurons contribute to compulsive grooming in Sapap3-KO mice.
nature.com/articles/s41467-0…
Li Li, MD, PhD retweeted
Excited to share our work in the @mbruchas lab on how endogenous opioids promote goal-directed behavior, funded by @NIDAnews. I am currently on the job market and this work will form the basis of my research program.
biorxiv.org/content/10.1101/…
Li Li, MD, PhD retweeted
New paper in collaboration with @DavePistonWUSTL @Jeongmini_L and Chen Kong! Here we start to look at the wild and crazy world of endogenous opioids in pancreatic alpha cells 😱😱😱🤩🤩
The role of mu-opioid receptors in pancreatic islet alpha cells biorxiv.org/cgi/content/shor… #biorxiv_physio
Li Li, MD, PhD retweeted
Check out our new pre-print co-led by @PiantadosiSean & @ProfJohnARogers, @MinKyuLeePhD & @MingzhengWu w/ help from @NeuroLuxInc, @AvilaROAD, @NUro_science, & Dr. Yonggang Huang. A device for combined intracranial drug delivery & photometric recording. biorxiv.org/cgi/content/shor…
Li Li, MD, PhD retweeted
Excited to share work from @mbruchas & @ProfJohnARogers labs led by myself, @MinKyuLeePhD and @MingzhengWu with help from @NeuroLuxInc, @AvilaROAD, @NUro_science, and Dr. Yonggang Huang. Here we describe a device for combined intracranial drug delivery and fluorescence recording.
An integrated microfluidic and fluorescence platform for probing in vivo neuropharmacology biorxiv.org/cgi/content/shor… #biorxiv_neursci
Li Li, MD, PhD retweeted
Very excited to share our work with this expert audience next Monday (5/13/2024). Please register at the link below if you are interested in attending!
Excited to announce our upcoming webinar with Dr. Piantadosi, @UW. He will describe his use of multiphoton #optogenetics to manipulate optically separable amygdalar valence encoding ensembles in vivo.
➡️ goto.bruker.com/3Wfa386
#neuroscience #brain
Li Li, MD, PhD retweeted
Excited to share our methods work out in #Neurophotonics today! We coupled a new microprism design with a long working distance objective to track thousands of cells across days in the striatum.
doi.org/10.1117/1.NPh.11.3.0…
Li Li, MD, PhD retweeted
Please apply to join my lab at Research Triangle Institute in North Carolina! We are seeking Ph.D. level scientists to join our team to work on mitochondrial mechanisms in substance use disorders. Apply here (or please RT/share):
careers.rti.org/jobs/11456?l…
Li Li, MD, PhD retweeted
Excited to share that my graduate dissertation work is now finally live on bioarxiv! Take a look if you're interested in learning more about the lateral septum's role in opioid withdrawal: biorxiv.org/content/10.1101/…
Li Li, MD, PhD retweeted
The Gillespie lab is looking for a tech to join our team in Seattle! Help us build some cool automated maze environments to study the neural mechanisms of memory impairment in aging and Alzheimer's disease! Details here: uwhires.admin.washington.edu…