MD Neurosurgeon | PhD Pharmacology. Developer. Fooled by randomness. Back on twitter because of A.I. If you suspect I'm wrong, see my pinned tweet
Helsinki, Finland
Joined December 2008
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- Following1.1K
- Followers3.8K
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Anyone with a laptop and a hundred dollars a month can change the world now. While on holiday.
Esa-Pekka Pälvimäki retweeted
All those years of refusing to learn Excel, Word and PowerPoint is about to pay off.
Esa-Pekka Pälvimäki retweeted
I gave Fable 5.2 a PDF of one of Leonardo da Vinci’s 500-year-old notebooks and it made his inventions real for me to interact with.
Such an exciting time for education. Anything from history that’s been stuck on a page can now be something you explore.
Esa-Pekka Pälvimäki retweeted
If there is one thing the AI revolution has taught me, it’s that 99% of people cannot extrapolate. At all. Quite literally people cannot imagine or visualize progress or changes beyond the current state. Complete inability to predict the future.
Esa-Pekka Pälvimäki retweeted
Earlier this week Tristan published his top YouTube channels:
thume.ca/2026/11/01/youtube-…
Which looked excellent so clearly I had to turn it into TristanTube:
karpathy.ai/tristan-tube/
47K super nerdy videos +TV mode for laid back watching. (One-shotted with Claude Code in 3 minutes)
Weekend hack: HackerTube. I was annoyed with YouTube's recommendations so I had Claude filter down 43M comments over 20 years of HN to 6,454 videos that keep being recommended. *Significantly* better viewing experience, ~2 hours with Opus 5.5:
hackertube.org/
- Excellent recs without any logins (state is kept in local browser session)
- Thumbnail is a representative frame from middle of the video instead of the super duper A/B test hyper-optimized user uploads
- Underlying data from the comment analysis as one zip file, point your Claude at it and ask for your own version
- HackerTube Longs ✊
A bit more on the process:
I use Claude Code (desktop app for Mac), Opus 5.5 on Medium effort as my default. I only talk to Claude and have it do everything, the only "manual work" I helped with in tandem was in the browser (reminiscent of MenuGen): 1) I had to create some kind of API key from Google Cloud UI to query YouTube for video metadata, 2) I booted up a VPS box for serving and 3) I bought the domain name. Once the box was up I gave Claude the IP and told it update, secure, harden, deploy and optimize the code, and it did the whole thing.
Many awesome projects that would have normally taken weeks/months even can now be few-shotted for breakfast. What else are we not thinking of.
Esa-Pekka Pälvimäki retweeted
Let me be blunt. Those who are afraid of AI feel deep down that they are impostors & have no edge. If you have a 1) clear mind, 2) a deep, not just cosmetic, undertanding of your specialty, 3) and/or are original enough to reinvent yourself when needed, AI will be your friend.
Not always easy to find the right setup. This seems to work so thought i'd share it, though it'll probably be stale in a week
708 PRs merged in Oct
Stack: Claude Code ultra + Codex pro subscriptions (1 each). Workers GLM-5.3 Flash xhigh → Terra 6.1 xhigh → Sol 6.1 high → Opus 5.5 medium or Sol 6.1 xhigh orchestrator, in ultracode mode. Grok bot for babysitting PRs and mobile orchestration.
Each PR: one cross-model review, GLM5.3 xhigh security review. Agents loop testing UI in browser/iOS simulator/phone rig. SHA-guarded auto-merge. Linear for issue tracking, though this is changing
Challenges: Disk space, cloud backup reliability, unnecessary hardcoded human gates in harnesses, costs creep up, complexity increases (hardware, security, management of scaling)
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credit where due i'm using @theo 's sol-loop, full-send and full-stop and a modified grill-me from @mattpocockuk in addition to a number of custom skills. haven't updated my skills repo in a while but will do if someone is interested
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