Physician-scientist-entrepreneur. Biotech CEO/CSO. Genetics, biotech, birds (mostly raptors), books.
San Mateo, CA
Joined January 2011
- Tweets367
- Following556
- Followers525
- Likes3.5K
Eric Green retweeted
OK, so the $ bio ai assistants are:
Ascent Bio - ascentbio.ai/
Bio Protocol BIOS - ai.bio.xyz/
Edison Scientific - edisonscientific.com/
K-Dense - k-dense.ai/
Potato - potato.ai/
SciSpace - scispace.com/biomedical/
Did I miss any?
Eric Green retweeted
We find TDP-43 loss to cause presynaptic defects, which are rescued by ASOs correcting a single cryptic exon in UNC13A.
Surprising effect of just one cryptic exon and promising strategy for ALS!
Matt Keuss @PeteHarley95 in great collaboration with @jbneuro
biorxiv.org/content/10.1101/…
Eric Green retweeted
If there was only one scientific practice I could teach to every scientist regardless of stage or field I think it would be: look at the data. Spot check it. Find a few data points and trace them through to see if they make sense. Look at the raw data. Don't just do analyses.
Eric Green retweeted
Here, substrate reduction therapy with GYS1 inhibition may be a promising therapeutic approach for Pompe disease and other glycogen storage diseases @ScienceTM science.org/doi/10.1126/scit…
Eric Green retweeted
A variant of APOL1, p.N264K, is associated with reduced risk of CKD and ESKD among carriers of APOL1 high risk variants to levels comparable to individuals with APOL1 low-risk genotypes bit.ly/JASN0219
@DrFlashHeart @MichaelEMatheny @KSusztak @Eddiesiew2 @CassyRCohen
ALT Association of APOL1 HR (homozygous for G1 or G2 or compound heterozygous for G1/G2) with and without p.N264K allele with CKD and ESKD among MVP participants, BioVU and the All of Us. APOL1, apolipoprotein L1; BioVU, Vanderbilt University Biobank; CI, confidence interval; FE, Fixed effect; HR, high risk; MVP, Million Veteran Program; OR, odds ratio.
Eric Green retweeted
A mutation in APOL1 that protects against kidney disease.
How does it work? Seems to reduce APOL1 pore function
Cool new work integrating human genetics with cellular APOL1 function.
👏@alexbickmdphd @ercgrn @MazeInBiotech
journals.lww.com/jasn/fullte…
Eric Green retweeted
A 🧵 on some of my intuitions/priors about the genetics of complex and molecular traits in humans (i.e. what I think of as typical), largely motivated by GWAS/QTL studies over the past decade [citing papers with nice figures where possible]
Eric Green retweeted
Dr. Stacy Johnson, Dr. Jeffrey Kopp, and Dr. Suzanne Nicholas presented a nice history and overview of APOL1 nephropathy at @GlomCon today. Here are some pearls:
1.) Black patients disproportionately develop CKD + ESKD than other populations.
Eric Green retweeted
I hope every single person reads this heartrending profile of a generous and decent couple who loved each other, their son, and their Queens neighbors. I have followed this story, and I am grateful for the reporting by @corinaknoll @nytimes nytimes.com/2022/04/19/nyreg…
Eric Green retweeted
Excited to share a study led by @mtvector1 from @lab_pollen describing contrasting developmental mechanisms contributing to primate inhibitory neuron evolution: nature.com/articles/s41586-0…
Eric Green retweeted
@ShouTiPharma @SentiBio @GenomeMed @zipline @KellerRinaudo @keenanwyrobek @MazeInBiotech @ercgrn @insitro @freenome @GabeOtte @plenty Congrats on being featured in our 2022 Best Tech Startups in South San Francisco! thetechtribune.com/best-tech…
Eric Green retweeted
Out @Nature!
TDP-43 path induces crucial synaptic UNC13A mis-splicing and loss. ALS risk SNPs exacerbate this, worsening disease progression.
We uncover the elusive UNC13A risk SNP mechanism, suggesting patients may do better if we correct UNC13A splicing.
nature.com/articles/s41586-0…
Eric Green retweeted
New paper @Nature! With Pietro Fratta’s team @UCL, we uncovered a link between TDP-43 mis-localization and mis-splicing of UNC13A, a key synaptic gene, in ALS. Exemplifies power of human iPSC neuron models in predicting disease mechanisms + team science.
nature.com/articles/s41586-0…
ALT Human iPSC neurons depleted of TDP-43 showing mis-splicing of UNC13A mRNA (white spots inside dapi-stained blue nuclei). https://www.nature.com/articles/s41586-022-04436-3 https://www.nature.com/articles/d41586-022-00383-1
Eric Green retweeted
Happy to discuss the removal of #race from #eGFR in light of new @ASNKidney @nkf guidelines on this @NEJM @NEJMres360 podcast! It's release is timely given hesitancy to change eGFR reporting and continued denial of the harms of race-based medicine. Check it out and tag a friend!
Tune in to a rich discussion about race and kidney disease with @AmakaEMD on NEJM Curbside Consults! Was so honored to have her on the podcast.
podcasts.apple.com/us/podcas…
Eric Green retweeted
“If you have a disease-causing gene and I have the disease-causing gene, why is it that you may be healthy and I may be sick?” said Maze Therapeutics CEO Jason Coloma. Maze launched out of @ThirdRockV earlier this year. #Fierce15 fiercebiotech.com/special-re…
Eric Green retweeted
Can a Smartwatch Detect HOCM? hcmbeat.com/2019/06/29/can-a… via @HCMBeat
Eric Green retweeted
#ArtificialIntelligence analysis of wearable biosensor data detects obstructive hypertrophic #cardiomyopathy with 98% accuracy
Link: nature.com/articles/s41746-0…
@ercgrn @MyoKardia @Nature_NPJ #AI #MedTwitterAI #MachineLearning #ML #biosensor #HealthTech #wearables #mHealth #MedTech
Eric Green retweeted
The diagnosis of hypertrophic cardiomyopathy is often missed. Using a wearable sensor and #AI (ML of PPG) it can be accurately detected
nature.com/articles/s41746-0… @Nature_NPJ Digital Medicine by @ercgrn and colleagues #openaccess
Eric Green retweeted
This is a big deal and biopharma should be paying much closer attention to it.
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Eric Green retweeted
Want to learn about how human genetics is impacting development of new medicines
Considering this @HMS_ExecEd course in Boston June 4/5 2019:
Functional Genomics & Drug Discovery
executiveeducation.hms.harva… …
👇🏾 faculty of all-⭐️⭐️
including Andy Plump, head R&D @TakedaPharma
