Evan Appleton (@evappleton) header
Evan Appleton (@evappleton) profile picture

Synthetic Biologist | Developmental Biologist | Bioinformatician

Boston, MA
Joined March 2015
Photo by Evan Appleton (@evappleton)Photo by Evan Appleton (@evappleton)Photo by Evan Appleton (@evappleton)Photo by Evan Appleton (@evappleton)
Researchers with Evan Appleton (@evappleton) at @colossal have generated the first #iPSCs from Asian elephants, providing a new platform for conservation and disease research. 🐘 Read more: go.nature.com/4y2YAc8 Listen to the discussion: bit.ly/3TCds1C
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Evan Appleton retweeted
Excited to welcome @evappleton from @colossal as a featured speaker!
If you're in the Boston area - come join us for the Engineering Biology Club next Thursday, October 3! hubs.la/Q02Rd-9Y0
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Evan Appleton retweeted
If you're in the Boston area - come join us for the Engineering Biology Club next Thursday, October 3! hubs.la/Q02Rd-9Y0
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Interested in Generative AI for BIO? Please Join George Church, David Baker and Sarah Carter for an interactive SynBioBeta Town Hall on "Generative AI for Protein Design: Balancing Risks with Opportunities". Tuesday Apr 16th at 12 noon pacific. You can register here: synbiobeta.zoom.us/webinar/r…
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Our Woolly Mammoth team has achieved a global-first iPSC breakthrough! 🏆 iPSC cells represent a single cell source that can propagate indefinitely and elephant iPSCs (the most elusive iPSCs to date) are now obtainable! #bioscience #deextinction #technology
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Cell-Cell adhesion work out in the journal..."Cell." A perfect fit! doi.org/10.1016/j.cell.2022.…
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Our group (led by Prof. @DouglasDensmore) is #hiring a Research Systems Engineer II to maintain and develop computational tools and manage IT systems for #microfluidics, lab #automation, and #synbio. Check out the post here: bu.silkroad.com/epostings/in…
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Paul Nurse, who won a Nobel for his work on the cell cycle, calls for more daring theory in biology and criticizes current trends in large scale data generation. We probably need to reimagine the Discussion section of papers! nature.com/articles/d41586-0…
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In work led by @StorkDevon & in collaboration between @fleshball & @geochurch, we report site-specific incorporation of a variety of non-standard amino acids in Bacillus subtilis for several purposes including interrogation of bacterial cytokinesis. Now out in @NatureComms (1/2)
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With $15 million in private funding, a new company called Colossal is trying to edit elephant DNA to genetically resurrect the woolly mammoth, thousands of years after it went extinct. nyti.ms/3nuA6GU
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The epsilon variant of #SARSCoV2, first detected California, carries three spike protein mutations that confer resistance to neutralizing antibodies generated by mRNA vaccines or by #SARSCoV2 infection, according to new research in Science. fcld.ly/2cej8vt
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Biotechnology has so much promise but sometimes poses risks. Fortunately, we can use engineering to lower risks. In our latest paper largely from @geochurch's lab, we show that synthetic auxotrophy holds up over time. Life doesn't always find a way #synbio advances.sciencemag.org/cont…
Synthetic biology is an emerging field with promise for improving our ability to manufacture chemicals, develop therapeutic medicines such as biopharmaceuticals and vaccines, and enhance agricultural production, among other things. cbe.udel.edu/news/2021/07/02…
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UPDATE: If you are fully vaccinated against #COVID19, you can resume activities without wearing a mask or staying 6 feet apart, except where required by federal, state, local, tribal or territorial laws, incl. local business and workplace guidance. More: bit.ly/3btJaFU
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GP-write Announces Development of Next-Gen CAD for Whole Genome Design: eurekalert.org/pub_releases/… @EurekAlert @Agilent @InscriptaInc @LatticeAutomatn @TwistBioscience
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GC Therapeutics is hiring stellar Stem Cell Biologists and Immunologists to join us in revolutionizing the field of hiPSC-derived cell therapies. Visit gc-tx.com/join-us for details.
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Evan Appleton retweeted
We are excited to have our Low-N protein design paper out in Nature Methods today! Absolute delight working with @grigonomics @EthanAlley @kesvelt and @geochurch
A deep learning guided approach from @SurgeBiswas @geochurch enables protein engineering using only a small number — “low-N” — of functionally characterized variants of target proteins. Full article: nature.com/articles/s41592-0…
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The new tool, dubbed IRENE, should boost tissue engineering efforts at Harvard Medical School and the @wyssinstitute hvrd.me/eiM730rBjB0
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