Evan Appleton (@evappleton) header
Evan Appleton (@evappleton) profile picture

Evan Appleton

@evappleton

Synthetic Biologist | Developmental Biologist | Bioinformatician

 Boston, MA
Joined March 2015
  • Tweets100
  • Following227
  • Followers220
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Photo by Evan Appleton (@evappleton)Photo by Evan Appleton (@evappleton)Photo by Evan Appleton (@evappleton)Photo by Evan Appleton (@evappleton)
Researchers with Evan Appleton (@evappleton) at @colossal have generated the first #iPSCs from Asian elephants, providing a new platform for conservation and disease research. 🐘 Read more: go.nature.com/4y2YAc8 Listen to the discussion: bit.ly/3TCds1C
Image from Stem Cell Podcast (@stemcellpodcast)
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Hot off the press at @naturemethods - our work to Derive elephant iPSCs! nature.com/articles/s41592-0…
Derivation of elephant induced pluripotent stem cells

Derivation of elephant induced pluripotent stem cells

Nature Methods - This study reports the first successful derivation of elephant induced pluripotent stem cells.

nature.com
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Replying to @officialMaxRye @LabCentral @c10labs
Looking forward to building Intertwined Biosciences with you and Jenhan Tao - it's going to be an exciting journey!
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ML-guided cell-fate engineering cell.com/callback?red_uri=%2…
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Evan Appleton retweeted
Ginkgo Bioworks (@Ginkgo) profile picture
Ginkgo Bioworks
@Ginkgo26 Sep 2024
Excited to welcome @evappleton from @colossal as a featured speaker!
Ginkgo Bioworks (@Ginkgo) profile pictureGinkgo Bioworks
@Ginkgo26 Sep 2024
If you're in the Boston area - come join us for the Engineering Biology Club next Thursday, October 3! hubs.la/Q02Rd-9Y0
Image from Ginkgo Bioworks (@Ginkgo)
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Evan Appleton retweeted
Ginkgo Bioworks (@Ginkgo) profile picture
Ginkgo Bioworks
@Ginkgo26 Sep 2024
If you're in the Boston area - come join us for the Engineering Biology Club next Thursday, October 3! hubs.la/Q02Rd-9Y0
Image from Ginkgo Bioworks (@Ginkgo)
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CAD software for designing multicellular shapes from a single cell progenitor finally published! pubs.acs.org/doi/10.1021/acs…
Algorithms for Autonomous Formation of Multicellular Shapes from Single Cells

Algorithms for Autonomous Formation of Multicellular Shapes from Single Cells

Abstract. Multicellular organisms originate from a single cell, ultimately giving rise to mature organisms of heterogeneous cell type composition in comple

pubs.acs.org
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Evan Appleton retweeted
John Cumbers (@johncumbers) profile picture
John Cumbers
@johncumbers1 Apr 2024
Interested in Generative AI for BIO? Please Join George Church, David Baker and Sarah Carter for an interactive SynBioBeta Town Hall on "Generative AI for Protein Design: Balancing Risks with Opportunities". Tuesday Apr 16th at 12 noon pacific. You can register here: synbiobeta.zoom.us/webinar/r…
Image from John Cumbers (@johncumbers)
Image from John Cumbers (@johncumbers)
Image from John Cumbers (@johncumbers)
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Our Woolly Mammoth team has achieved a global-first iPSC breakthrough! 🏆 iPSC cells represent a single cell source that can propagate indefinitely and elephant iPSCs (the most elusive iPSCs to date) are now obtainable! #bioscience #deextinction #technology
Image from Colossal Biosciences® (@colossal)
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biorxiv.org/content/10.1101/… Elephant induced pluripotent stem cells
DERIVATION OF ELEPHANT INDUCED PLURIPOTENT STEM CELLS

DERIVATION OF ELEPHANT INDUCED PLURIPOTENT STEM CELLS

The crisis of biodiversity loss in the anthropogenic era requires new tools for studying non-model organisms. Elephants, for example, are both an endangered species and excellent models studying...

biorxiv.org
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@svheeringen Our bad if we missed some more recent papers! If you DM me some more references, we will be sure to qualify our statements more in review!
Great to see @geochurch becoming a developmental biologist (it's never too late) Systematic identification of txn factor receipes for cell fate reprogramming biorxiv.org/content/10.1101/…
Machine-guided cell-fate engineering

Machine-guided cell-fate engineering

The creation of induced pluripotent stem cells (iPSCs) has enabled scientists to explore the derivation of many types of cells. While there are diverse general approaches for cell-fate engineering,...

biorxiv.org
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Evan Appleton retweeted
Tim Wannier (@TimWannier) profile picture
Tim Wannier
@TimWannier1 Sep 2022
Cell-Cell adhesion work out in the journal..."Cell." A perfect fit! doi.org/10.1016/j.cell.2022.…
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Creating programmable cellular assembly via orthogonal cell-surface binding proteins just published: cell.com/cell/fulltext/S0092…
helixCAM: A platform for programmable cellular assembly in bacteria and human cells

helixCAM: A platform for programmable cellular assembly in bacteria and human cells

Engineered orthogonally interacting coiled coils presented on the surface of cells enable specific cell-cell or cell-surface interactions for the controlled formation of complex multicellular...

cell.com
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Our work developing a protein-based delivery system was just published! cell.com/cell-reports/fullte…
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Lattice Automation is #hiring! We are looking for a #productmanager to be part of a team focused on delivering cutting edge #software solutions: linkedin.com/posts/lattice-a…
#hiring #productmanager #software #vaccines | Lattice Automation

#hiring #productmanager #software #vaccines | Lattice Automation

Lattice Automation is #hiring! We are looking for a #productmanager to be part of a team focused on delivering cutting edge #software solutions to scientists creating the next generation of #vaccines...

linkedin.com
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Evan Appleton retweeted
CIDAR Lab (@cidar_lab) profile picture
CIDAR Lab@cidar_lab30 Sep 2021
Our group (led by Prof. @DouglasDensmore) is #hiring a Research Systems Engineer II to maintain and develop computational tools and manage IT systems for #microfluidics, lab #automation, and #synbio. Check out the post here: bu.silkroad.com/epostings/in…
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Evan Appleton retweeted
Patrick Hsu (@pdhsu) profile picture
Patrick Hsu
@pdhsu14 Sep 2021
Paul Nurse, who won a Nobel for his work on the cell cycle, calls for more daring theory in biology and criticizes current trends in large scale data generation. We probably need to reimagine the Discussion section of papers! nature.com/articles/d41586-0…
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Aditya Kunjapur (@kunjapur) profile picture
Aditya Kunjapur@kunjapur14 Sep 2021
In work led by @StorkDevon & in collaboration between @fleshball & @geochurch, we report site-specific incorporation of a variety of non-standard amino acids in Bacillus subtilis for several purposes including interrogation of bacterial cytokinesis. Now out in @NatureComms (1/2)
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With $15 million in private funding, a new company called Colossal is trying to edit elephant DNA to genetically resurrect the woolly mammoth, thousands of years after it went extinct. nyti.ms/3nuA6GU
A New Company With a Wild Mission: Bring Back the Woolly Mammoth (Published 2021)

A New Company With a Wild Mission: Bring Back the Woolly Mammoth (Published 2021)

With $15 million in private funding, Colossal aims to bring thousands of woolly mammoths back to Siberia. Some scientists are deeply skeptical that will happen.

nytimes.com
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