@f_fauser

Genome Engineer | Early R&D Scientist @SangamoTx | Postdoc @JonikasLab, @CarnegiePlants & @PrincetonMolBio | PhD @PuchtaLab, @KITKarlsruhe | Tweets are my own

 Fremont, CA
Joined September 2014
  • Tweets99
  • Following49
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🧬🚀 We’ve made substantial progress in development of our modular integrase, or MINT, platform- a gene editing method that we believe will enable large-scale genome engineering. Our updated manuscript which showcases these advances is available on bioRxiv bit.ly/41Y14ud
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Martin Jonikas@JonikasLab19 Dec 2024
We are excited to share 71,700 new #Chlamy mutants from the CLiP2 collection pre-publication! Nearly-saturating genome coverage. Please note: new background strain, mating type, and antibiotic resistance. Read: biorxiv.org/content/10.1101/… Search and order: chlamylibrary.org/
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Martin Jonikas@JonikasLab10 Aug 2024
Excited to share our latest preprint! Biogenesis, engineering and function of membranes in the CO2-fixing pyrenoid biorxiv.org/content/10.1101/…

Biogenesis, engineering and function of membranes in the CO2-fixing pyrenoid

Approximately one-third of global CO2 assimilation is performed by the pyrenoid[1][1], a liquid-like organelle found in most algae and some plants[2][2]. Specialized membranes are hypothesized to...

biorxiv.org
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After a mere blink in the cosmos -3 years as a preprint- our paper has found its home in @NatureComms . Thanks to all coauthors, the long supporting journey @Dinnenylab, and collaborators @JonikasLab and Michael Sussman. Oh, and by the way, I'm job hunting!!!
Josep Vilarrasa Blasi@pituvilarnadal20 Jul 2021
Preprint Alert!! We took a systems biology approach to establish #Chlamy as a simplified system to study osmotic stress pathways and identified conserved pathways across the green lineage, uncovering a new role for actin during osmotic stress acclimation, thread
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One of our lead scientists, @wraithnot is presenting @FASEBorg about our exciting Modular Integrase (MINT) platform, a new approach to 🎯 integration of large 🧬 constructs into precise locations within the human genome. #genomicmedicine #MINTplatform
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Systematic Development of Reprogrammed Modular Integrases Enables Precise Genomic Integration of Large DNA Sequences biorxiv.org/content/10.1101/…

Systematic Development of Reprogrammed Modular Integrases Enables Precise Genomic Integration of...

Despite recent progress in the ability to manipulate the genomes of eukaryotic cells[1][1]–[3][2], there is still no effective and practical method to precisely integrate large synthetic DNA constr...

biorxiv.org
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Jeff Miller@wraithnot17 May 2024
Our #MINTplatform does not use #CRISPR, #ZincFinger or #TALeffector to 🎯 DNA. Instead, we directly reprogram Bxb1 integrase to go where we want in the human genome. The details are in our @bioRxiv paper: bit.ly/3wwPLwy
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We are thrilled to announce the publication of our manuscript detailing the development of our Modular Integrase (MINT) platform #MINTplatform is now live on @bioRxiv! bit.ly/3wwPLwy @f_fauser @gdavis624 @arangundy @wraithnot
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Jeff Miller@wraithnot11 May 2024
Systematic Development of Reprogrammed Modular Integrases Enables Precise Genomic Integration of Large DNA Sequences biorxiv.org/content/10.1101/… - our paper describing reprogrammed serine integrases is now on BioRxiv!

Systematic Development of Reprogrammed Modular Integrases Enables Precise Genomic Integration of...

Despite recent progress in the ability to manipulate the genomes of eukaryotic cells[1][1]–[3][2], there is still no effective and practical method to precisely integrate large synthetic DNA constr...

biorxiv.org
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Tom Ellis@ProfTomEllis11 May 2024
Cool new preprint from Sangamo, engineering BxbI integrase to target native sites in the genome. Who needs landing pads now?
bioRxiv Synthetic Biology@bioRxiv_synbio11 May 2024
Systematic Development of Reprogrammed Modular Integrases Enables Precise Genomic Integration of Large DNA Sequences ift.tt/1aEgDKj #biorxiv_synbio
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MINT platform reprograms Bxb1 integrase for precise genome editing. Achieving up to 35% efficiency, it integrates kilobase-sized constructs into specific genomic sites, including human TRAC and AAVS1 loci.🧬👨‍🔬✂️#GenomeEditing #SyntheticBiology #GeneTherapy biorxiv.org/content/10.1101/…

Systematic Development of Reprogrammed Modular Integrases Enables Precise Genomic Integration of...

Despite recent progress in the ability to manipulate the genomes of eukaryotic cells[1][1]–[3][2], there is still no effective and practical method to precisely integrate large synthetic DNA constr...

biorxiv.org
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Sangamo Therapeutics@SangamoTx9 May 2024
Today at #ASGCT2024 is the platform presentation for our next-generation Modular Integrase (MINT) technology, engineered to enable large-scale genome editing. Learn how the MINT platform utilizes Bxb1, to integrate large sequences of 🧬 into the genome. bit.ly/3QhlQyY
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Sangamo Therapeutics@SangamoTx9 May 2024
We are excited to announce next-generation Modular Integrase (MINT) technology, engineered to enable large-scale genome editing. The MINT platform is a versatile, protein-guided genome editing method designed to integrate large sequences of 🧬bit.ly/44GSRe4
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New paper in #naturecomms unveils compact ZF Base Editor showing highly efficient engineering of human T cells by discovering a deaminase and pairing w/ a ZF nickase. Compact architecture allows packaging in a single AAV, promising in vivo therapeutic app bit.ly/3I1mvA3

Compact zinc finger architecture utilizing toxin-derived cytidine deaminases for highly efficient...

Nature Communications - The most recent class of base editors utilize DddAtox, a deaminase domain that can act upon double-stranded DNA. Here the authors target DddAtox fragments and a FokI-based...

nature.com
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Robert Jinkerson@JinkersonLab2 Aug 2022
Check out the @NatGeo article about our recent work on growing food w/o photosynthesis written by @themadstone Can food crops grow in the dark? Scientists are working out how. nationalgeographic.com/envir…

Can food crops grow in the dark? Scientists are working out how.

Experiments suggest that it might become possible to nourish plants without photosynthesis—a tool that could one day help feed astronauts and a crowded planet.

nationalgeographic.com
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Petra Redekop@RedekopPetra30 May 2022
After two incredible #CarnegiePlant scientists owned this Van and drove through the US, the Van is looking for a new owner. Is it again going to be a scientist ready for big adventures? #VW #VanagonGL
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Plantae@plantae_org10 Jun 2022
Plant Science Research Weekly -- Systematic characterization of gene function in the photosynthetic alga Chlamydomonas reinhardtii (Nature Genetics) @JinkersonLab @JonikasLab @pituvilarnadal @f_fauser (Summary by Jiawen Chen @jiaaawen) buff.ly/3a6exrS
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Today at #ASGCT22, we will showcase our zinc finger platform's capabilities for high-efficiency base editing in human cells. Learn how: bit.ly/3xKCMW0 #ASGCT #GenomicMedicine #GeneTherapy #CellTherapy
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Amy Pooler@amyymelissa17 May 2022
Great energy at the #ASGCT22 conference! Quick coffee ahead of the afternoon session with Jason Fontenot, Sangamo’s CSO @JaDaFo   #GenomicMedicine #GeneTherapy #celltherapy @SangamoTx
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Amy Pooler@amyymelissa17 May 2022
Sr. Scientist David Ojala’s presentation at #ASGCT22 shared exciting progress of our proprietary approach to engineering novel AAV capsids for improved brain delivery. Proud to be part of a scientific team working so hard to improve care options for patients! @SangamoTx – at Washington, DC
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